Bacterial interactions in pathogenic subgingival plaque

Ng, Hong Min; Kin, Lin Xin; Dashper, Stuart G.; Slakeski, Nada; Butler, Catherine A.; Reynolds, Eric C.

doi:10.1016/j.micpath.2015.10.022

Cited by 47 publications

(44 citation statements)

References 108 publications

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“…Finally, the presence of P. intermedia was not associated at all with disease activity. It is well known that these three bacteria commonly occur together in the same periodontal inflammatory process, and there is ample biological evidence that confirms their interrelationship (Endo et al, , Ng et al, , Zhu & Lee, ). In this sense, it is hard to understand why T. forsythia was not previously compared with P. gingivalis (Wegner et al, ) based on PAD type activity.…”

Section: Discussionmentioning

confidence: 97%

Salivary ammonia levels andTannerella forsythiaare associated with rheumatoid arthritis: A cross sectional study

Martínez-Rivera

Xibillé-Friedmann

González-Christen

et al. 2017

Clinical & Exp Dental Res

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The aim of this paper is to evaluate the relationship of salivary ammonium levels and the presence of bacteria with rheumatoid arthritis (RA) clinical disease activity in a cross‐sectional study of Mexican patients. From a periodontal and disease activity standpoint, 132 consecutive RA patients fulfilling clinical criteria were evaluated. Ammonia levels (including peptidyl arginine deiminase activity) were evaluated by colorimetric assay and the presence of Porphyromonas gingivalis, Tannerella forsythia, and Prevotella intermedia was evaluated by polymerase chain reaction (PCR) technique. After a multivariate analysis, adjusting for clinical and serological parameters, a significant association was only observed between severe periodontitis and probing depth with high RA disease activity. Additionally, in contrast to P. gingivalis, the presence of T. forsythia was significantly associated with high disease RA activity even after multivariable adjustment analysis. There was also a significant increase in ammonium levels in the high RA activity group and a significant correlation between salivary ammonia and RA disease activity but not with autoantibody titers. Similarly, we observed a significant increase in the ammonium levels derived from the cultures of P. gingivalis and T. forsythia, with respect to P. intermedia and S. gordonii cultures, or even healthy donors. These results suggest that RA activity is associated with severe periodontitis, high salivary ammonium levels and the presence of T. forsythia.

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Section: Discussionmentioning

confidence: 97%

Salivary ammonia levels andTannerella forsythiaare associated with rheumatoid arthritis: A cross sectional study

Martínez-Rivera

Xibillé-Friedmann

González-Christen

et al. 2017

Clinical & Exp Dental Res

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“…S. gordonii and P. gingivalis are oral bacteria initiating the formation of dental plaques contributing in turn to the onset of dental caries and periodontal diseases as well as their progression [10]. We have previously demonstrated that these bacteria are sensitive to new drugs which are of natural origin as they are derived from lichen secondary metabolites [7,25].…”

Section: Resultsmentioning

confidence: 99%

“…gordonii are bound by Porphyromonas gingivalis and form a highly pathogenic complex microbial community [8], [9]. S. gordonii, as a pioneer initial colonizer, initiates the formation of dental plaques contributing in turn to the onset of dental caries and periodontal diseases as well as their progression [10]. Inhibiting S. gordonii might block the successive steps leading to acute oral diseases and introduce new antibiotics that might be able to prevent and treat the periodontal diseases.…”

Section: Introductionmentioning

confidence: 99%

Lichen butyrolactone derivatives disrupt oral bacterial membrane

Sweidan

Smida²,

Chollet-Krugler³

et al. 2019

Fitoterapia

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We have previously demonstrated that out of the butyrolactones series synthesized based on the natural lichen metabolite lichesterinic acid, compound (B-13) was the most effective against oral bacteria. However, its antibacterial mechanism is still unknown. In this study, we have investigated its bacterial localization by synthesizing a fluorescently labeled B-13 with NBD while maintaining its antibacterial activity. We showed that this compound binds to Streptococcus gordonii cell surface, as demonstrated by HPLC analysis. By adhering to cell surface, B-13 induced cell wall disruption leading to the release of bacterial constituents and consequently, the death of S. gordonii, a Gram-positive bacterium. A Gram-negative counterpart, Porphyromanas gingivalis, showed also cracked and ruptured cells in the presence of B-13. Besides, we also demonstrated that the analog of B-13, B-12, has also induced disruption of P. gingivalis and S. gordonii. This study revealed that butyrolactones can be considered as potent antibacterial compounds against oral pathogens causing medical complications.

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“…In addition, the modulation of the host immunoinflammatory response is involved. Hence, the destruction of the supporting periodontal tissues is dependent on factors other than the inflammatory process (Ng et al., ). This may have been the reason for not obtaining significant results regarding the control of alveolar bone loss in the first group of this study.…”

Section: Discussionmentioning

confidence: 99%