Bacterial interference for the prevention and treatment of infections

Falagas, Matthew E.; Rafailidis, Petros I.; Makris, Gregory C.

doi:10.1016/j.ijantimicag.2008.01.024

Cited by 43 publications

(31 citation statements)

References 52 publications

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“…The past decade has witnessed an increasing interest in studying the ecology of host-associated microbiota. As one of the potential beneficial effects conferred by these indigenous microbial communities, colonization resistance has been implicated in protecting host against pathogens and has received great attention (Rolfe, 1997;Brook, 1999;Adlerberth et al, 2000;Fons et al, 2000;Reid et al, 2001;Guarner and Malagelada, 2003;Reid et al, 2003;Alain, 2004;Dillon et al, 2005;Falagas et al, 2008). However, due to the complexity of host-associated indigenous microbial community, it is very difficult to identify the bacterial species responsible for colonization resistance and to Figure 4 Survival of E. coli within synthetic oral communities in two-chamber assay.…”

Section: Discussionmentioning

confidence: 99%

“…Among the proposed beneficial effects, the ability of the indigenous community to resist the invasion and colonization by exogenous organisms, termed colonization resistance, has been regarded as one of the major functions of the host-associated microbiota (Brook, 1999;Reid et al, 2001;Falagas et al, 2008). It has been extensively documented in invertebrate-as well as vertebrate-associated commensal microbial communities (Veivers et al, 1982;Guarner and Malagelada, 2003;Dillon et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

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The social structure of microbial community involved in colonization resistance

He¹,

McLean

Guo³

et al. 2013

The ISME Journal

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It is well established that host-associated microbial communities can interfere with the colonization and establishment of microbes of foreign origins, a phenomenon often referred to as bacterial interference or colonization resistance. However, due to the complexity of the indigenous microbiota, it has been extremely difficult to elucidate the community colonization resistance mechanisms and identify the bacterial species involved. In a recent study, we have established an in vitro mice oral microbial community (O-mix) and demonstrated its colonization resistance against an Escherichia coli strain of mice gut origin. In this study, we further analyzed the community structure of the O-mix by using a dilution/regrowth approach and identified the bacterial species involved in colonization resistance against E. coli. Our results revealed that, within the O-mix there were three different types of bacterial species forming unique social structure. They act as 'Sensor', 'Mediator' and 'Killer', respectively, and have coordinated roles in initiating the antagonistic action and preventing the integration of E. coli. The functional role of each identified bacterial species was further confirmed by E. coli-specific responsiveness of the synthetic communities composed of different combination of the identified players. The study reveals for the first time the sophisticated structural and functional organization of a colonization resistance pathway within a microbial community. Furthermore, our results emphasize the importance of 'Facilitation' or positive interactions in the development of community-level functions, such as colonization resistance.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The social structure of microbial community involved in colonization resistance

He¹,

McLean

Guo³

et al. 2013

The ISME Journal

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show abstract

“…Under such competitive selection it is not surprising that bacteria have developed special mechanisms in order to interfere with the capability of other antagonistic bacteria during the process of surface colonization and acquisition of nutrients (Falagas et al, 2008). The mechanisms of bacterial antagonism would include depletion of some essential substances (e.g., a substrate or a vitamin), alteration in the microenvironment (e.g., changes in the gas concentration or pH), or production of an antagonistic substance (e.g., antibiotics; Wannamaker, 1980), but also the presentation of a real obstacle or barrier to other microorganisms by competing directly for the host-cell-binding sites (as shown by Reid et al, 2001).…”

Section: Ecological Role Of Epibiotic Bacteria: Modulation Of Host-enmentioning

confidence: 99%

The Second Skin: Ecological Role of Epibiotic Biofilms on Marine Organisms

Wahl¹,

Goecke²,

Labes³

et al. 2012

Front. Microbio.

388

314

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In the aquatic environment, biofilms on solid surfaces are omnipresent. The outer body surface of marine organisms often represents a highly active interface between host and biofilm. Since biofilms on living surfaces have the capacity to affect the fluxes of information, energy, and matter across the host’s body surface, they have an important ecological potential to modulate the abiotic and biotic interactions of the host. Here we review existing evidence how marine epibiotic biofilms affect their hosts’ ecology by altering the properties of and processes across its outer surfaces. Biofilms have a huge potential to reduce its host’s access to light, gases, and/or nutrients and modulate the host’s interaction with further foulers, consumers, or pathogens. These effects of epibiotic biofilms may intensely interact with environmental conditions. The quality of a biofilm’s impact on the host may vary from detrimental to beneficial according to the identity of the epibiotic partners, the type of interaction considered, and prevailing environmental conditions. The review concludes with some unresolved but important questions and future perspectives.

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“…The concept that one bacterial strain or species can prevent infection by another -termed bacterial interference -has been of longstanding interest in infectious diseases (61)(62)(63). In this context, an avirulent strain or species that outcompetes more pathogenic strains may be useful as a probiotic to prevent infections.…”

Section: Escherichelin Does Not Support Iron-dependent E Coli Growthmentioning

confidence: 99%