Bacterial Interference with L-Forms

Boris, Marvin; Teubner, Diane; Shinefield, Henry R.

doi:10.1128/jb.100.2.791-795.1969

Cited by 5 publications

(1 citation statement)

References 6 publications

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“…This finding supports the concept that natural mycobacterial population usually consists of prevalent classical forms and small numbers of L-forms. There is data reporting about coexistence of classical walled and cell wall deficient L-forms within natural populations of other bacteria as well as about relations of concurrence and interference between them under different conditions (Boris et al, 1969;Fodor and Roger, 1966). Extreme morphological plasticity of bacteria has been found to provide survival advantages (Justice et al, 2008;Young, 2007).…”

Section: Yin-yang Hypothesis For Co-existence Of Classical and L-forms Within Natural Mycobacterial Populationmentioning

confidence: 99%

Understanding Tuberculosis - Deciphering the Secret Life of the Bacilli

Cardona¹

2012

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Section: Yin-yang Hypothesis For Co-existence Of Classical and L-forms Within Natural Mycobacterial Populationmentioning

confidence: 99%

Understanding Tuberculosis - Deciphering the Secret Life of the Bacilli

Cardona¹

2012

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Growth inhibition of bacterial variants

Marraro¹,

Pfister²,

Rheins³

1970

Can. J. Microbiol.

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A phenomenon is described which apparently resulted from a parent form of Streptococcus faecalis inhibiting the growth of the L-form of the same organism in the area of the medium immediately surrounding the classic colonial parent form. It seemed significant that both the parental form of the streptococcus and the L-form variant were isolated simultaneously and directly from a urine specimen without the purposeful intervention of laboratory manipulations, such as the introduction of "inducers" into the medium.

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Exhibition of persistent and drug-tolerant L-form habit of Mycobacterium tuberculosis during infection in rats

et al. 2008

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Abstract:A model for studying mycobacterial L-form formation in vivo was established to demonstrate the ability of M. tuberculosis to behave as a drug-tolerant L-form persister. Rats were infected by intranasal (i.n.) and intraperitoneal (i.p.) routes with 1x10 8 cells/ml of M. tuberculosis. At weekly intervals during a period of five weeks, samples from lung, spleen, liver, kidney, mesenterial and inguinal lymph nodes, broncho-alveolar and peritoneal lavage liquid were plated simultaneously on Löwenstein-Jensen (LJ) medium or inoculated into specially supplemented for L-forms Dubos broth (drug-free and drug-containing variants). The use of liquid media enabled isolation of mycobacterial L-form cultures during the whole period of experiment including the last two weeks, when tubercle bacilli were not isolated on LJ medium. An unique feature of mycobacterial L-forms was their ability to grow faster than the classical tubercle bacilli. Isolation and growth of L-form cultures in primary drug-containing media demonstrated their drug-tolerant properties. Electron microscopy of liquid media isolates showed that they consisted of morphologically heterogenous populations of membrane-bound and of variable sized L-bodies that completely lack cell walls. The identity of the isolated non-acid fast and morphologically modified L-forms as M. tuberculosis was verified by specific spoligotyping test. The results contribute to special aspects concerning the importance of mycobacterial L-form phenomenon for persistence and latency in tuberculosis, phenotypic drug tolerance, as well as for diagnosis of difficult to identify morphologically changed tubercle bacilli which are often mistaken for contaminants.

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Bacterial Interference with L-Forms

Cited by 5 publications

References 6 publications

Understanding Tuberculosis - Deciphering the Secret Life of the Bacilli

Understanding Tuberculosis - Deciphering the Secret Life of the Bacilli

Growth inhibition of bacterial variants

Exhibition of persistent and drug-tolerant L-form habit of Mycobacterium tuberculosis during infection in rats

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