Bacterial Isolates and its Antibiotic Susceptibility Pattern in NICU

Shrestha, Sunaina; Shrestha, Niti; Singh, Sudhir; Shrestha, Rabi; Kayestha, S; Shrestha, Manzil; Thakur, Nagesh

doi:10.3126/kumj.v11i1.11030

Cited by 58 publications

(82 citation statements)

References 16 publications

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“…This was in accordance with the study by Shrestha, which showed that vancomycin was effective in 100 % isolates 7 . However, in study conducted by Kayagne vancomycin was effective against 14 % strains only while study by Shahian showed that ceftazidime was effective only in 22% 15,9 .…”

Section: Resultssupporting

confidence: 93%

“…These results were comparable with study done by Shrestha 7 . In some other studies done by Shahian 9 and Dias 14 , results showed that strains were sensitive to gentamycin only in 50 % and 63 % cultures respectively 9,14 .…”

Section: Resultssupporting

confidence: 92%

“…Similar results were observed in studies done by Aletayeb and Shrestha who showed 90 % and 100 % sensitivity towards imepenam, respectively 11,7 . In contrast to our study, Kayagne showed only 2 % sensitivity to meropenem and Shahian showed only 33 % sensitivity to imepenem 15,9 .…”

Section: Resultssupporting

confidence: 90%

“…We observed that in our study total 163 microbial culture and sensitivity tests were done, of which 62 % culture were found to be positive. This is higher than that reported by Shreshtha S et al and Shahian et al in which the blood culture positivity rate was 44% and 43% respectively [7][8] . In our hospital culture and sensitivity reports are done on the day of admission and empirical antimicrobial therapy is started with Cefotaxime and Amikacin combination.…”

Section: Resultscontrasting

confidence: 65%

“…Klebsiella Pneumoniae, Staphylococcus Aureus and CONS were the predominant organisms in the study done by Shrestha S et al and Jyothi P et al 7,12 . Pseudomonas Aeroginosa was the predominant organism for neonatal sepsis followed by Klebsiella and Acinobacter in the study done by Bhat R et al 13 .…”

Section: Resultsmentioning

confidence: 81%

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2016

IJPSR

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Purpose: Neonatal sepsis, a major killer among neonate, necessitates urgent implementation of empirical therapy and later specific antimicrobial therapy against causative microorganism. Empirical therapy relies upon data obtained from previous studies. We conducted this study to evaluate the blood culture, sensitivity and resistance pattern of various antimicrobial agents in neonatal sepsis at Neonatal Intensive Care Unit at a tertiary care hospital in western part of India, which will show us the changing pattern of etiological organism and antimicrobials needed to curb them. Methods: We conducted a prospective cross sectional study over a period of six month duration in Neonatal Intensive Care Unit at tertiary care hospital. We collected and analyzed the blood culture reports and sensitivity pattern of antimicrobials used. Results: We enrolled 163 patients of neonatal sepsis. Paediatricians sent 163 blood samples for culture of which 62 % culture were positive. Out of 101 positive cultures 70 % were Gram negative organisms. Most frequently encountered organisms were Klebsiella Pneumonia followed by Acinobacter species while least common was Coagulase Negative Staphylococci. Conclusion: Our world is facing a huge issue of development of resistance to antimicrobial agents by microorganisms. Irrational prescribing habits of physicians are leading to increasing morbidity, mortality and treatment costs. To prevent antimicrobial resistance, regular educational awareness programs should be conducted in hospitals at a regular basis. Also comparative studies in the same hospital over years will help us to generate proper antimicrobial policies ultimately leading to rationale drug therapy.

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Section: Resultssupporting

confidence: 93%

Section: Resultssupporting

confidence: 92%