Bacterial Isolates and Resistance Patterns in Preterm Infants with Sepsis in Selected Hospitals in Ethiopia: A Longitudinal Observational Study

Eshetu, Beza; Gashaw, Mulatu; Solomon, Semaria; Berhane, Melkamu; Molla, Kassie; Abebe, Tamrat; Gizaw, Solomon Tebeje; Abdissa, Alemseged; Abayneh, Mahlet; Goldenberg, Robert L.; Tigabu, Zemene; Mekasha, Amha; Worku, Bogale; McClure, Elizabeth M; Nigusse, Assaye K; Muhe, Lulu

doi:10.1177/2333794x20953318

Cited by 17 publications

(18 citation statements)

References 26 publications

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“…78.3% of bacteria isolated in the current study were multi-drug resistant where the majority of it occurs among Gram-negative bacteria (92%). The finding is in agreement with studies conducted in different parts of Ethiopia 10 , 31 . All Pseudomonas species , Acinetobacter species, Enterobacter aglemerans were MDR.…”

Section: Discussionsupporting

confidence: 93%

“…The results are consistent with another study conducted in Bhutan 25 . Gram-negative bacteria were the most commonly isolated bacteria causing neonatal sepsis in this study, which is in line with studies conducted by Eshetu et al 10 and Lamba et al 8 . This study revealed that most EOS (86.8%) are caused by Gram-negative bacteria.…”

Section: Discussionsupporting

confidence: 93%

“…The types of organisms that cause neonatal sepsis change over time and vary from region to region 9 . Blood culture remains the gold standard for diagnosis of neonatal sepsis, regardless of its low sensitivity which may be due to the small volume of the blood sample or the use of empirical antibiotics prior to sampling 10 . In this study, we envisaged determining the etiology and associated factors of sepsis among clinically suspected newborns.…”

Section: Introductionmentioning

confidence: 99%

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Bacterial etiology and risk factors among newborns suspected of sepsis at Hawassa, Ethiopia

Worku

Fenta

Ali

2022

Sci Rep

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Neonatal sepsis is a systemic infection that occurs at an early age. Its etiology varies from one region to the other. The contribution of sepsis to neonatal mortality and morbidity is significant in resource-limited countries; however, there is limited information about the etiology of sepsis in Sidama Regional State, Ethiopia. The aim of this study was to determine the prevalence of bacterial caused newborn sepsis, associated factors, and the antimicrobial susceptibility profile of bacteria. A hospital-based prospective cross-sectional study was conducted among 392 sepsis suspected newborns admitted to the neonatal intensive care unit of Hawassa University Comprehensive Specialized Hospital from March 2021 to November 2021. Blood specimens were collected and bacteria were isolated using the standard culture method. The drug resistance profile of bacteria was evaluated using the disk diffusion method. The socio-demographic and clinical parameters of participants were gathered using a questionnaire. Binary logistic regression was used to determine the determinants of sepsis. A variable with a p < 0.05 was considered a significant determinant of neonatal sepsis with a 95% confidence level. The prevalence of sepsis caused by bacteria among newborns was 143 (36.5%); 95% CI (31.3–41.4). The predominant bacteria was Klebsiella species (n = 61; 42.65%), followed by non-lactose fermenting Gram-negative bacteria (n = 27; 18.88%) and Enterococcus species (n = 26; 18.18%). The overall proportions of antimicrobial resistance of Gram-negative bacteria range from 10.2 to 99.1%. All Klebsiella species were resistant to ceftriaxone. Ppremature rupture of membrane [AOR = 12.7 (95% CI 6.430–25.106)], absence of respiratory support [AOR = 3.53 (95% CI 1.840–6.759)], sex of newborns [AOR = 2.10 (1.214–3.560)] and reason for admission [AOR = 3.17 (95% CI 1.278–7.859)] were significantly associated with culture-confirmed neonatal sepsis. This study indicated the contribution of bacteria in causing sepsis among newborns; the majority of them were Gram-negative bacteria. Most recovered bacteria were resistant to commonly used antibiotics. Pre-term, mode of delivery and types of respiratory support were significantly associated with the occurrence of sepsis caused by bacteria.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

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Bacterial etiology and risk factors among newborns suspected of sepsis at Hawassa, Ethiopia

Worku

Fenta

Ali

2022

Sci Rep

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“…Among infants with the diagnosis of sepsis, Klebsiella species, Coagulase negative Staphylococcus and Staphylococcus aureus were the predominant pathogens isolated by blood culture. 15 Ciprofloxacin was the most effective drug against the Gram-positive and Gram-negative bacteria, whereas resistance to the more commonly used antibiotics such as; ampicillin and gentamycin was very high, more than 80%. 15 Other investigations such as complete blood count and bilirubin were done in most cases.…”

mentioning

confidence: 99%

“… 15 Ciprofloxacin was the most effective drug against the Gram-positive and Gram-negative bacteria, whereas resistance to the more commonly used antibiotics such as; ampicillin and gentamycin was very high, more than 80%. 15 Other investigations such as complete blood count and bilirubin were done in most cases. Abnormal WBC and platelet counts were the most common to be associated with Early Onset Neonatal Sepsis (EONS), asphyxia and RDS.…”

mentioning

confidence: 99%