Bacterial isolates and their antibiotic susceptibility patterns among patients with pus and/or wound discharge at Gondar university hospital

Abstract

BackgroundIn spite of advances in control of infections, wound infections have not completely controlled due to many reasons. The widespread uses of antibiotics, together with the length of time over which they have been available have led to major problems of resistant organisms contributing to morbidity and mortality. This study was aimed to assess bacterial isolates and their drug susceptibility patterns from patients with pus and/or wound discharge.MethodsA retrospective study was conducted at Gondar University Hospital from all individuals who provide pus and/or wound discharge sample from September, 2009 to August, 2012. Socio-demographic and laboratory results were collected from the University Hospital Microbiology Laboratory unit registration books by using a standard data collection format. Data were analyzed using SPSS version 20 software. P-value ≤ 0.05 was considered statistically significant.ResultA total of 628 study subjects were included in the study with bacterial isolation rate of 441 (70.2%). Of all, 344 (54.8%) were males. Two hundred eighty two (63.9%) of the isolates were gram positive and 159 (36.1%) were gram negative. About 331/ 441 (75.0%) of the total isolates were Staphylococcus aureus (32.9%), Coagulase Negative staphylococci (14.7%), Streptococcus spp. (11.6%), Escherichia coli (9.5%), Klebsiella spp. (6.3%). The result showed that 66.2% of the isolates were resistant to tetracycline, followed 59.8% for ampicillin, 59.1% for cotrimoxazole, 51.7% for penicillin; least resistant being 6.3% for gentamycin.ConclusionHigh prevalence of bacterial isolates were found; S. aureus being the dominant. Most of the isolates were resistant to many of the antibiotics tested where all isolates of Pseudomonas spp. being resistant to two or more antibiotics. Antibiotic susceptibility test is necessary for effective control of wound infections.

Antibiotic Susceptibility Patterns of Bacterial Isolates from Pus Samples in a Tertiary Care Hospital of Punjab, India

“…S. aureus was highly susceptible to vancomycin (100%), linezolid (100%), imipenem (89%), and meropenem (84%) while it showed resistance to ampicillin, amoxicillin-clavulanic acid, ciprofloxacin, and azithromycin. Unlike some reports in which MRSA was associated with wound infections [16, 17], our findings revealed susceptibility in S. aureus isolates towards cloxacillin and cephalosporins. P. mirabilis and Streptococcus isolates, however, exhibited minimal resistance and were susceptible to most of the antibiotics (Table 1).…”

Isolation, Identification and Antibiotic Susceptibility Pattern of Bacteria Isolated from Wounds of Patients Attending at Arsho Advanced Medical Laboratory

“…In the breakdown of bacterial pathogens isolated, S.aureus isolates predominates, followed by E.coli, and Citrobacterspp, which is contrary to the pattern reported in some studies and varies with the frequency of isolation [12][13][14], but similar result was revealed by [15].…”

Microbial Profile and Antimicrobial Susceptibility Pattern of Pus Culture Isolates from a Teaching Tertiary Care Hospital, South India

“…Since these infections are associated with high morbidity prompt antibiotic therapy is mandatory. An increase incidence of multidrug resistant Gram negative bacteria and Methicillin resistant Staphylococcus aureus is frequently isolated from pyogenic infections under hospital settings (Muluye et al, 2014;Trojan et al, 2016). The emergence of antibiotic resistant pathogens poses a grave threat to the health care system.…”