2016
DOI: 10.4172/2155-9570.1000591
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Bacterial Keratitis Risk Factors, Pathogens and Antibiotic Susceptibilities: A 5- Year Review of Cases at Dubai hospital, Dubai

Abstract: Objective: Microbial keratitis is a sight threatening infection of the cornea. Its incidence has been increased in the past few years, with the contact lens wear as the major risk factor. In the past few years other risk factors have also come up in light. We thus aimed to present a 5-year study comprising of 37 patients with microbial keratitis who yielded only positive culture; other cases with negative cultures were excluded.Methods: Local microbiology database and retrospective audit of patients (who had a… Show more

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Cited by 3 publications
(6 citation statements)
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“…Our findings indicate that in some cases, bacterial pathogens originating from conjunctival microbiota may be responsible for the infection in patients with CLABK rather than external pathogens, as we identified the same bacterial species of the corneal infiltrate using cultivation and in the conjunctiva at the corresponding genus level using 16S rRNA gene amplicon sequencing. In addition, known pathogens to bacterial keratitis such as Pseudomonas aeruginosa [ 1 , 15 , 16 , 17 ], Stenotrophomonas species [ 1 , 16 ], Staphylococcus species [ 16 , 24 ], Serratia species [ 1 , 16 , 24 ], and Cutibacterium acnes [ 25 , 26 ] were identified at the genus level in the whole study population, which further confirmed our hypothesis that commensal bacteria in the conjunctiva could be opportunistic pathogens. Ge et al [ 9 ] reported similar results for patients with fungal keratitis and controls [ 9 ] regarding the identification of Pseudomonas , Serratia , and Staphylococcus in conjunctival microbiota.…”
Section: Discussionsupporting
confidence: 82%
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“…Our findings indicate that in some cases, bacterial pathogens originating from conjunctival microbiota may be responsible for the infection in patients with CLABK rather than external pathogens, as we identified the same bacterial species of the corneal infiltrate using cultivation and in the conjunctiva at the corresponding genus level using 16S rRNA gene amplicon sequencing. In addition, known pathogens to bacterial keratitis such as Pseudomonas aeruginosa [ 1 , 15 , 16 , 17 ], Stenotrophomonas species [ 1 , 16 ], Staphylococcus species [ 16 , 24 ], Serratia species [ 1 , 16 , 24 ], and Cutibacterium acnes [ 25 , 26 ] were identified at the genus level in the whole study population, which further confirmed our hypothesis that commensal bacteria in the conjunctiva could be opportunistic pathogens. Ge et al [ 9 ] reported similar results for patients with fungal keratitis and controls [ 9 ] regarding the identification of Pseudomonas , Serratia , and Staphylococcus in conjunctival microbiota.…”
Section: Discussionsupporting
confidence: 82%
“…Biofilm formation on contact lenses is presumed to contribute to the increased risk of bacterial keratitis [ 37 ]. A higher relative abundance of Pseudomonas [ 9 ], a known bacterial pathogen to bacterial keratitis [ 1 , 2 , 15 , 16 , 17 ], has been reported for patients with fungal keratitis [ 9 ]; however, this finding was not confirmed in our study, nor for other pathogens, e.g., Staphylococcus [ 16 , 24 ], Serratia [ 1 , 16 , 24 ], Stenotrophomonas [ 1 , 16 ], or Cutibacterium [ 25 , 26 ]. Contact lenses disrupt protective mechanisms, such as the intact corneal epithelium, by mechanically causing punctate erosions, thus leaving the cornea more susceptible to infection [ 38 ].…”
Section: Discussionmentioning
confidence: 99%
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“…These results differ with one study carried out in the UAE that found Pseudomonas aeruginosa to be the most common causative organism. 13 This discrepancy in the prevalence of the causative organism could be explained due to the low number of contact lens usage in our sample, which is known to be associated…”
Section: Discussionmentioning
confidence: 80%
“…10,11 Moreover, ocular trauma has been the most common cause of corneal ulcer in low-income countries (77.5%). 12 Conversely, ocular trauma was found to be less common in some studies conducted in France and the UAE, 12,13 which could be due to the difference in the socio-economic status. OSD was the second most commonly associated factor leading to bacterial keratitis (29.4%), which seems to be high compared to other studies.…”
Section: Discussionmentioning
confidence: 99%