Semiconducting and metallic nanomaterials are essential building blocks for developing modern-age technologies, and their demand is expanding exponentially with a growing population. However, their processing impacts the ecosystem and requires urgently sustainable solutions. This perspective underlines the emergence of microbe-mediated (bacteria, yeast, fungi, microalgae, viruses, cyanobacteria) green nanomaterials, including metal-based, carbon-based, organic and hybrid nanomaterials, with technical challenges of scalability, stability and cytotoxicity restricting their transition from lab-to-market. Besides, it discusses alternative solutions by integrating digital-age technologies like artificial intelligence to establish these green nano-semiconductors/metals for multidimensional applications and subsidizing the UN’s sustainable development goals and One Health management.