Bacterial nanocellulose patches as a carrier for hydrating formulations to improve the topical treatment of nail diseases

Bellmann, Tom; Luber, Ruth; Kischio, Lisa; Karl, Berit; Pötzinger, Yvette; Beekmann, Uwe; Kralisch, Dana; Wiegand, Cornelia; Fischer, Dagmar

doi:10.1016/j.ijpharm.2022.122267

Cited by 6 publications

(4 citation statements)

References 62 publications

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“…this increase in transparency correlated with decreasing water content and, more importantly, with the rising refractive index of the ME formulations (Section 3.1.3). As suggested previously by Bellmann et al [58], the difference in transparency could be explained by the convergence of refractive indices of incorporated fluid and matrix material.…”

Section: Transparencysupporting

confidence: 52%

“…While for native BC a relatively low transparency of 12.70 ± 2.17% was found, there was a remarkable increase in transparency for BC-ME, ranging from 50.12 ± 3.27% for BC-ME-A, up to 74.94 ± 2.43% for BC-ME-E. Interestingly, this increase in transparency correlated with decreasing water content and, more importantly, with the rising refractive index of the ME formulations ( Section 3.1.3 ). As suggested previously by Bellmann et al [ 58 ], the difference in transparency could be explained by the convergence of refractive indices of incorporated fluid and matrix material. The authors observed similar effects for loaded BC with glycerol/urea water mixtures of different compositions and hypothesized, with reference to Wildner et al [ 95 ], that the matching refractive index led to minimized light scattering and thus increased transparency.…”

Section: Resultsmentioning

confidence: 58%

“…Transparency of loaded BC-ME patches was assessed as previously described, with minor modifications [ 31 , 58 ]. The patches were transferred to a 24-well plate (Greiner, Nuertingen, Germany), and mean transmission at 650 nm was measured at five points located on the surface of the patches (Tecan Infinite ® M Nano, Tecan, Männedorf, Switzerland).…”

Section: Methodsmentioning

confidence: 99%

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Exploring Microemulsion Systems for the Incorporation of Glucocorticoids into Bacterial Cellulose: A Novel Approach for Anti-Inflammatory Wound Dressings

Zahel,

Bruggink,

Hülsmann

et al. 2024

Pharmaceutics

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The effective pharmacological treatment of inflamed wounds such as pyoderma gangraenosum remains challenging, as the systemic application of suitable drugs such as glucocorticoids is compromised by severe side effects and the inherent difficulties of wounds as drug targets. Furthermore, conventional semi-solid formulations are not suitable for direct application to open wounds. Thus, the treatment of inflamed wounds could considerably benefit from the development of active wound dressings for the topical administration of anti-inflammatory drugs. Although bacterial cellulose appears to be an ideal candidate for this purpose due to its known suitability for advanced wound care and as a drug delivery system, the incorporation of poorly water-soluble compounds into the hydrophilic material still poses a problem. The use of microemulsions could solve that open issue. The present study therefore explores their use as a novel approach to incorporate poorly water-soluble glucocorticoids into bacterial cellulose. Five microemulsion formulations were loaded with hydrocortisone or dexamethasone and characterized in detail, demonstrating their regular microstructure, biocompatibility and shelf-life stability. Bacterial cellulose was successfully loaded with the formulations as confirmed by transmission electron microscopy and surprisingly showed homogenous incorporation, even of w/o type microemulsions. High and controllable drug permeation through Strat-M® membranes was observed, and the anti-inflammatory activity for permeated glucocorticoids was confirmed in vitro. This study presents a novel approach for the development of anti-inflammatory wound dressings using bacterial cellulose in combination with microemulsions.

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Section: Transparencysupporting

confidence: 52%

Section: Resultsmentioning

confidence: 58%

Section: Methodsmentioning

confidence: 99%

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Exploring Microemulsion Systems for the Incorporation of Glucocorticoids into Bacterial Cellulose: A Novel Approach for Anti-Inflammatory Wound Dressings

Zahel,

Bruggink,

Hülsmann

et al. 2024

Pharmaceutics

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“…Additionally, the water used for the precipitation was probed after the finished process and analyzed for the occurrence of CBD by HPLC. Vertical Franz diffusion cells (Gauer Glas, Püttlingen, Germany) were used to investigate the release behavior of the loaded fleeces, as described before [ 45 ]. Loaded BNC fleeces were placed in the donor compartment of the cells and fixed with a thin defined aluminum foil cross, resulting in a direct contact area of 1.48 cm 2 between the BNC fleece and release medium.…”

Section: Methodsmentioning

confidence: 99%

In situ Formation of Polymer Microparticles in Bacterial Nanocellulose Using Alternative and Sustainable Solvents to Incorporate Lipophilic Drugs

et al. 2023

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Bacterial nanocellulose has been widely investigated in drug delivery, but the incorporation of lipophilic drugs and controlling release kinetics still remain a challenge. The inclusion of polymer particles to encapsulate drugs could address both problems but is reported sparely. In the present study, a formulation approach based on in situ precipitation of poly(lactic-co-glycolic acid) within bacterial nanocellulose was developed using and comparing the conventional solvent N-methyl-2-pyrrolidone and the alternative solvents poly(ethylene glycol), CyreneTM and ethyl lactate. Using the best-performing solvents N-methyl-2-pyrrolidone and ethyl lactate, their fast diffusion during phase inversion led to the formation of homogenously distributed polymer microparticles with average diameters between 2.0 and 6.6 µm within the cellulose matrix. Despite polymer inclusion, the water absorption value of the material still remained at ~50% of the original value and the material was able to release 32 g/100 cm2 of the bound water. Mechanical characteristics were not impaired compared to the native material. The process was suitable for encapsulating the highly lipophilic drugs cannabidiol and 3-O-acetyl-11-keto-β-boswellic acid and enabled their sustained release with zero order kinetics over up to 10 days. Conclusively, controlled drug release for highly lipophilic compounds within bacterial nanocellulose could be achieved using sustainable solvents for preparation.

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Micro/nanostructure and directional channel of recyclable carboxylated aerogels from waste cotton for wastewater treatment

Gong,

Zhang,

Chen

et al. 2024

Cellulose

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Bacterial nanocellulose patches as a carrier for hydrating formulations to improve the topical treatment of nail diseases

Cited by 6 publications

References 62 publications

Exploring Microemulsion Systems for the Incorporation of Glucocorticoids into Bacterial Cellulose: A Novel Approach for Anti-Inflammatory Wound Dressings

Exploring Microemulsion Systems for the Incorporation of Glucocorticoids into Bacterial Cellulose: A Novel Approach for Anti-Inflammatory Wound Dressings

In situ Formation of Polymer Microparticles in Bacterial Nanocellulose Using Alternative and Sustainable Solvents to Incorporate Lipophilic Drugs

Micro/nanostructure and directional channel of recyclable carboxylated aerogels from waste cotton for wastewater treatment

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