Bacterial Pathogen Helicobacter pylori: A Bad AKT or Inhibits p53 Protein Activity

p53, a potential predictor ofHelicobacter pyloriinfection-associated gastric carcinogenesis?

“…Notably, higher levels of mutant p53 and MDM2 were observed in H. pylori -positive patients with MA and Dys, and the expression of phosphorylated AKT was upregulated in CNAG patients with H. pylori infection. The expression of pAKT and MDM2 was also significantly increased after H. pylori strains were co-cultured with GES-1 gastric epithelial cells, which also supports the degradation of p53 [ 76 , 77 ]. Inhibition of MDM2 activity using siRNA or the inhibitor Nutlin3 in AGS human GC cells clearly inhibited the downregulation of H. pylori -induced p53.…”

Up-regulation of Tight-Junction Proteins by p38 Mitogen-Activated Protein Kinase/p53 Inhibition Leads to a Reduction of Injury to the Intestinal Mucosal Barrier in Severe Acute Pancreatitis

“…7,8 Activated p53 not only plays an important role in tumor-related diseases but also functions in the progression of inflammatory diseases. 9 It has been well documented that inflammatory conditions of the intestinal mucosa result in compromised barrier function. 10 To date, however, the precise molecular mechanisms that lead to the failure of gut mucosal barrier function in SAP are poorly understood.…”