Bacterial Peptidoglycans from Microbiota in Neurodevelopment and Behavior

Gonzalez-Santana, Ayoze; Heijtz, Rochellys Diaz

doi:10.1016/j.molmed.2020.05.003

Cited by 62 publications

(34 citation statements)

References 113 publications

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“…In recent years, there has been keen interest in exploring the gut-microbiota-brain axis [197][198][199][200][201]. Growing evidence suggests that the gut microbiota can act as an effective regulator of host body weight and psychiatric disorders [140,[202][203][204][205].…”

Section: Clinical Relevancementioning

confidence: 99%

From gut microbiota to host appetite: gut microbiota-derived metabolites as key regulators

et al. 2021

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Feelings of hunger and satiety are the key determinants for maintaining the life of humans and animals. Disturbed appetite control may disrupt the metabolic health of the host and cause various metabolic disorders. A variety of factors have been implicated in appetite control, including gut microbiota, which develop the intricate interactions to manipulate the metabolic requirements and hedonic feelings. Gut microbial metabolites and components act as appetite-related signaling molecules to regulate appetite-related hormone secretion and the immune system, or act directly on hypothalamic neurons. Herein, we summarize the effects of gut microbiota on host appetite and consider the potential molecular mechanisms. Furthermore, we propose that the manipulation of gut microbiota represents a clinical therapeutic potential for lessening the development and consequence of appetite-related disorders.

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Section: Clinical Relevancementioning

confidence: 99%

From gut microbiota to host appetite: gut microbiota-derived metabolites as key regulators

et al. 2021

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“…However, fewer studies have been conducted to answer how the microbiota might influence addiction-related behaviors, such as “food/eating addiction”. Even though the research to date is not complete, increasing evidence shows how microbiota dysbiosis is implicated in the development of these maladaptive habits [ 8 , 10 , 58 , 168 , 169 , 170 , 171 , 172 ] ( Figure 3 ). Considering this, all factors affecting the “healthy” composition of the GM, including host genetics [ 173 , 174 ], diet [ 175 , 176 ], age [ 177 , 178 ], mode of birth [ 179 , 180 ], and antibiotics intake [ 181 , 182 ], among others, can shape GM and ultimately trigger an abnormal eating behaviour.…”

Section: Interrelationship Between Gut Microbiota and Food Addictionmentioning

confidence: 99%

Decoding the Role of Gut-Microbiome in the Food Addiction Paradigm

Novelle

2021

IJERPH

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Eating behaviour is characterised by a solid balance between homeostatic and hedonic regulatory mechanisms at the central level and highly influenced by peripheral signals. Among these signals, those generated by the gut microbiota have achieved relevance in recent years. Despite this complex regulation, under certain circumstances eating behaviour can be deregulated becoming addictive. Although there is still an ongoing debate about the food addiction concept, studies agree that patients with eating addictive behaviour present similar symptoms to those experienced by drug addicts, by affecting central areas involved in the control of motivated behaviour. In this context, this review tries to summarise the main data regarding the role of the gut microbiome in eating behaviour and how a gut dysbiosis can be responsible for a maladaptive behaviour such as “food addiction”.

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“…The diversity of muropeptide structures is further generated by autolysins, such as peptidases, amidases, and glycosylases. There can be as many as 80 different muropeptides in a bacteria's PG network (Glauner, 1988;Burroughs et al, 1993b;Bui et al, 2012), each with variable ability to invoke a host immune response.…”

Section: Bacterial Envelope Pampsmentioning

confidence: 99%

“…Cell envelope components are released into the cerebrospinal fluid (CSF) gradually during growth or rapidly during antibioticinduced autolysis (Tuomanen et al, 1985a;Arditi et al, 1989;Woodhams et al, 2013;Gonzalez-Santana and Diaz Heijtz, 2020). All three meningeal pathogens are autolytic and therefore undergo rapid cell envelope release during stationary phase and during antibiotic therapy.…”

Section: Cell Envelope Release: Antibiotics Vs Normal Growthmentioning

confidence: 99%

Mini-Review: Bioactivities of Bacterial Cell Envelopes in the Central Nervous System

MacCain

Tuomanen

2020

Front. Cell. Infect. Microbiol.

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During acute bacterial meningitis, recognition of the bacterial envelope by immune cells of the central nervous system (CNS) generates a robust response that is essential to clear bacteria. This response is further amplified during treatment when lytic antibiotics, required for cure, also generate a burst of highly inflammatory cell envelope debris. Different peptidoglycan (PG) subcomponents interact with neurons, glia, and the blood brain barrier resulting in the entire symptom complex of meningitis. Recently, this CNS-cell envelope signaling axis has been extended to non-inflammatory recognition of cell wall components circulating from endogenous bacteria to the brain resulting in both benefit and chronic damage. This review will describe the molecular details of a broad array of cell envelope-induced responses in the CNS and what current strategies can be implemented to improve clinical outcome.

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Bacterial Peptidoglycans from Microbiota in Neurodevelopment and Behavior

Cited by 62 publications

References 113 publications

From gut microbiota to host appetite: gut microbiota-derived metabolites as key regulators

From gut microbiota to host appetite: gut microbiota-derived metabolites as key regulators

Decoding the Role of Gut-Microbiome in the Food Addiction Paradigm

Mini-Review: Bioactivities of Bacterial Cell Envelopes in the Central Nervous System

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