Bacterial pericarditis and empyema caused by Cutibacterium acnes in a patient with metastatic lung cancer

R, Do Steven; Kar, Papia; Mitra, Subhashis

doi:10.1016/j.anaerobe.2021.102365

Cited by 2 publications

(2 citation statements)

References 15 publications

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“…Patients such as ours with hemodynamic compromise or high suspicion for purulent pericarditis should undergo pericardial drainage with subsequent fluid analysis [ 1 ]. Cutibacterium acnes is typically susceptible to penicillin, cephalosporin, carbapenems, vancomycin and aminoglycosides [ 12 ]. The duration of therapy can be variable.…”

Section: Discussionmentioning

confidence: 99%

A Case of Cutibacterium acnes Pericardial Effusion After Coronary Artery Bypass Surgery

Moodie,

Taylor,

Shepple

2023

Cureus

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Cutibacterium acnes is a gram-positive, anaerobic rod commonly found on the skin and mucosal membrane. It is mostly associated with its role in acne formation, but here we present a case of purulent pericarditis secondary to C. acnes after coronary artery bypass graft surgery (CABG). A 58-year-old male presented for CABG after a coronary angiogram showed severe multivessel disease. The procedure was performed successfully. He had minimal complications until postop day seven, when he developed a fever and hypoxia. The transthoracic echo (TTE) was largely unrevealing. Due to further declining status the following day, a transesophageal echo (TEE) was performed and revealed a loculated pericardial effusion not visualized on TTE. This was subsequently drained, and fluid cultures grew C. acnes. The patient received five weeks of antibiotic therapy, which improved his condition.

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Section: Discussionmentioning

confidence: 99%

A Case of Cutibacterium acnes Pericardial Effusion After Coronary Artery Bypass Surgery

Moodie,

Taylor,

Shepple

2023

Cureus

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“…43 There have also been reports of infections following skin biopsies in patients with metastatic lung cancer, resulting in pericarditis and empyema. 44 Although Xanthomonas campestris, Pseudomonas ficuserectae, Rhizobium oryzihabitans, Schlegelella aquatica, Pseudomonas yamanorum, and Rubrobacter xylanophilus exhibited significant differences between the COPD and normal groups, the six bacteria are not human normal flora and there was no report as pathogens in human.…”

mentioning

confidence: 97%

Profiling of Microbial Landscape in Lung of Chronic Obstructive Pulmonary Disease Patients Using RNA Sequencing

Shin,

Kim,

Lee

et al. 2023

COPD

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The aim of the study was to use RNA sequencing (RNA-seq) data of lung from chronic obstructive pulmonary disease (COPD) patients to identify the bacteria that are most commonly detected. Additionally, the study sought to investigate the differences in these infections between normal lung tissues and those affected by COPD. Patients and Methods: We re-analyzed RNA-seq data of lung from 99 COPD patients and 93 non-COPD smokers to determine the extent to which the metagenomes differed between the two groups and to assess the reliability of the metagenomes. We used unmapped reads in the RNA-seq data that were not aligned to the human reference genome to identify more common infections in COPD patients. Results: We identified 18 bacteria that exhibited significant differences between the COPD and non-COPD smoker groups. Among these, Yersinia enterocolitica was found to be more than 30% more abundant in COPD. Additionally, we observed difference in detection rate based on smoking history. To ensure the accuracy of our findings and distinguish them from false positives, we doublecheck the metagenomic profile using Basic Local Alignment Search Tool (BLAST). We were able to identify and remove specific species that might have been misclassified as other species in Kraken2 but were actually Staphylococcus aureus, as identified by BLAST analysis. Conclusion:This study highlighted the method of using unmapped reads, which were not typically used in sequencing data, to identify microorganisms present in patients with lung diseases such as COPD. This method expanded our understanding of the microbial landscape in COPD and provided insights into the potential role of microorganisms in disease development and progression.

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Bacterial pericarditis and empyema caused by Cutibacterium acnes in a patient with metastatic lung cancer

Cited by 2 publications

References 15 publications

A Case of Cutibacterium acnes Pericardial Effusion After Coronary Artery Bypass Surgery

A Case of Cutibacterium acnes Pericardial Effusion After Coronary Artery Bypass Surgery

Profiling of Microbial Landscape in Lung of Chronic Obstructive Pulmonary Disease Patients Using RNA Sequencing

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