Bacterial Persistence in Streptococcal Endocarditis Due to Thiol-Requiring Mutants

Cayeux, P; Acar, J. F.; Chabbert, Y

doi:10.1093/infdis/124.3.247

Cited by 66 publications

(36 citation statements)

References 20 publications

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“…L-forms are resistant to cell wall-active agents and form colonies with a "fried egg" appearance on osmotically supportive solid media, similar to those of mycoplasmas (38). Frenkel and Hirsch (25) found that two of their four NVS isolates produced typical L-form colonies, but other authors (13,28) were unable to demonstrate L-form growth with any of their strains.…”

Section: Morphological Observationsmentioning

confidence: 98%

“…They hypothesized that their strains were unable to reduce disulfide bonds, a defect overcome by the addition of sulfhydryl compounds to the growth medium. Other studies (11,13,39) demonstrated that L-cysteine was an effective supplement for NVS growth. Cayeux and co-workers (13) used brain heart infusion as a basal medium and found that good growth was produced by either L-cysteine or glutathione in combination with either thioglycolate or dithiothreitol.…”

Section: Physiological and Taxonomic Studies Nutritional Requirementsmentioning

confidence: 99%

“…While satellite growth can be observed after 24 h of incubation, colonies at the outer edge of the zone become enlarged at 48 h, presumably because of the abundance of nutrients in the surrounding medium (25). Satelliting colonies are usually nonhemolytic or alpha-hemolytic, and a variety of gram-positive and gram-negative bacteria (staphylococci, streptococci, family Enterobacteriaceae strains) as well as yeasts will support their growth (13,25,39). However, strains of Streptococcus pyogenes (39) and Pseudomonas aeruginosa (11) were reported to be unable to serve as helper bacteria for NVS.…”

Section: Morphological Observationsmentioning

confidence: 99%

“…However, strains of Streptococcus pyogenes (39) and Pseudomonas aeruginosa (11) were reported to be unable to serve as helper bacteria for NVS. NVS colonies are small, measuring 0.2 to 0.5 mm in diameter (13,39).…”

Section: Morphological Observationsmentioning

confidence: 99%

“…The possibility that these stimulatory compounds were encouraging growth by altering redox potential was addressed by a number of authors (13,25,28). Anaerobiosis alone would not allow growth of NVS; their nutritional requirements remained the same regardless of the growth atmosphere.…”

Section: Physiological and Taxonomic Studies Nutritional Requirementsmentioning

confidence: 99%

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Nutritionally variant streptococci

1991

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Streptococci requiring either pyridoxal or L-cysteine for growth were first observed 30 years ago as organisms forming satellite colonies adjacent to colonies of "helper" bacteria. Although they were previously considered nutritional mutants of viridans streptococcal species, the nutritionally variant streptococci (NVS) are currently thought to belong to distinct species of the genus Streptococcus. NVS strains may display pleomorphic cellular morphologies, depending on their growth conditions, and are distinguished from most other streptococci by enzymatic and serological characteristics and the presence of a cell wall chromophore. NVS are found as normal inhabitants of the oral cavity, and in addition to their participation in endocarditis, they have been isolated from a wide range of clinical specimens. Endocarditis caused by NVS is often difficult to eradicate; combinations of penicillin and an aminoglycoside are recommended for treatment. The unique physiological features of the NVS contribute to the difficulties encountered in their recovery from clinical specimens and may play a role in the problems associated with successful treatment of NVS endocarditis.

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Section: Morphological Observationsmentioning

confidence: 98%

Section: Physiological and Taxonomic Studies Nutritional Requirementsmentioning

confidence: 99%

Section: Morphological Observationsmentioning

confidence: 99%

Section: Morphological Observationsmentioning

confidence: 99%

Section: Physiological and Taxonomic Studies Nutritional Requirementsmentioning

confidence: 99%

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Nutritionally variant streptococci

1991

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Cure of Streptococcal Endocarditis With Six Days of Antibiotic Therapy

Bricaire¹

1986

JAMA

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1. Wei JY, Harris WS: Heart rate response to cough. J Appl Physiol 1982;53:1039-1043. 2. Shaw WM, Papper EA, Rovenstine EA: The influence of dibenamine upon circulatory reactions to ephedrine and neo-synephrine in normal men. J Lab Clin Med 1949;34:669-673. 3. McIntosh HD, Estes EH, Warren JV: The mechanism of cough syncope. Am Heart J 1956;52:70-82. 4. Larson SJ, Sances A Jr, Baker JB, et al: Herniated cerebellar tonsils and cough syncope. J Neurosurg 1974; 40:524-528. 5. Hart G, Oldershaw PJ, Coli RE, et al: Syncope caused by cough-induced complete atrioventricular block. Pace 1982;5:564-566.

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Infectious Diseases

Marier¹,

Sanders²

1983

Family Medicine

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Bacterial Persistence in Streptococcal Endocarditis Due to Thiol-Requiring Mutants

Cited by 66 publications

References 20 publications

Nutritionally variant streptococci

Nutritionally variant streptococci

Cure of Streptococcal Endocarditis With Six Days of Antibiotic Therapy

Infectious Diseases

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