Bacterial Proteases in Helicobacter pylori Infections and Gastric Disease

Wessler, Silja; Posselt, Gernot

doi:10.1007/978-3-031-47331-9_10

Current Topics in Microbiology and Immunology

2023

DOI: 10.1007/978-3-031-47331-9_10

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Bacterial Proteases in Helicobacter pylori Infections and Gastric Disease

Silja Wessler,

Gernot Posselt

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2024

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Two remarkable serine/leucine polymorphisms in Helicobacter pylori: functional importance for serine protease HtrA and adhesin BabA

Backert,

Tegtmeyer,

Horn

et al. 2024

Cell Commun Signal

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Single nucleotide polymorphisms (SNPs) account for significant genomic variability in microbes, including the highly diverse gastric pathogen Helicobacter pylori. However, data on the effects of specific SNPs in pathogen-host interactions are scarce. Recent functional studies unravelled how a serine/leucine polymorphism in serine protease HtrA affects the formation of proteolytically active trimers and modulates cleavage of host cell-to-cell junction proteins during infection. A similar serine/leucine mutation in the carbohydrate binding domain of the adhesin BabA controls binding of ABO blood group antigens, enabling binding of either only the short Lewis b/H antigens of blood group O or also the larger antigens of blood groups A and B. Here we summarize the functional importance of these two remarkable bacterial SNPs and their effect on the outcome of pathogen-host interactions.

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Two remarkable serine/leucine polymorphisms in Helicobacter pylori: functional importance for serine protease HtrA and adhesin BabA

Backert,

Tegtmeyer,

Horn

et al. 2024

Cell Commun Signal

View full text Add to dashboard Cite

show abstract

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Bacterial Proteases in Helicobacter pylori Infections and Gastric Disease

Cited by 1 publication

References 90 publications

Two remarkable serine/leucine polymorphisms in Helicobacter pylori: functional importance for serine protease HtrA and adhesin BabA

Two remarkable serine/leucine polymorphisms in Helicobacter pylori: functional importance for serine protease HtrA and adhesin BabA

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