Bacterial redox response factors in the management of environmental oxidative stress

Sudharsan, M.; Prasad, Nagarajan Rajendra; Saravanan, R.

doi:10.1007/s11274-022-03456-5

Cited by 8 publications

(1 citation statement)

References 184 publications

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“…In the PTT/PDT and synergistic antibacterial groups, we observed an upregulation of recA and uvrB expression, confirming that the synergistic ROS antibacterial effect led to DNA damage in bacteria contributing to apoptosis. In addition, we noticed a rapid upregulation of heat stress genes 41 (mcsB, mcsA, and ctsR) when photothermal treatments were performed, and, similarly, a rapid upregulation of oxidative stress genes 42 (trxB, katA, and sodA) when photodynamic treatments were performed. The results further confirmed that HA-Fe-COF was antibacterial mainly through thermal and oxidative stress damage.…”

Section: Synergistic Properties Of the Ha-fe-cofmentioning

confidence: 75%

Ambient Synthesis of Porphyrin-Based Fe-Covalent Organic Frameworks for Efficient Infected Skin Wound Healing

Chen,

Feng,

Zhu

et al. 2024

Biomacromolecules

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Reactive oxygen species (ROS) have emerged as a promising treatment option for antibacterial and biofilm eradication. However, their therapeutic efficacy is significantly hampered by the unique microenvironments of diabetic wounds. In this study, we designed and synthesized porphyrin-based Fe covalent organic frameworks (Fe-COF) through a Schiff base condensation reaction. Subsequently, Fe-COF were encapsulated with hyaluronic acid (HA) through electrostatic adsorption, resulting in a novel formulation named HA-Fe-COF for diabetic wound healing. HA-Fe-COF were engineered to respond to hyaluronidase in the infected wound, leading to the controlled release of Fe-COF. Those released Fe-COF served a dual role as photosensitizers, generating singlet oxygen and localized heating when exposed to dual light sources. Additionally, they acted as peroxidase-like nanozymes, facilitating the production of ROS through enzymatic reactions. This innovative approach enabled a synergistic therapeutic effect combining photodynamic, photothermal, and chemodynamic modalities. Furthermore, the sustained release of HA from HA-Fe-COF promoted angiogenesis, collagen deposition, and re-epithelialization during the diabetic wound healing process. This “all-in-one” strategy offers a novel approach for the development of antimicrobial and biofilm eradication strategies that minimize damage to healthy tissues in vivo.

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Section: Synergistic Properties Of the Ha-fe-cofmentioning

confidence: 75%