Bacterial resistance to the tetracyclines.

Chopra, Ian; Howe, T G

doi:10.1128/mmbr.42.4.707-724.1978

Cited by 60 publications

(30 citation statements)

References 95 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Based on these results, ampicillin resistance was more easily achieved than oxytetracycline resistance for V. harveyi LMG4044. The antibiotic resistance mechanism for oxytetracycline involves the production of proteins whose function is to prevent tetracycline invading the cell (Chopra & Howe, 1978). On the other hand, ampicillin resistance involves the production of the enzyme β‐lactamase, which hydrolyses β‐lactam antibiotics.…”

Section: Discussionmentioning

confidence: 99%

Comparison ofVibrio harveyistrains isolated from shrimp farms and from culture collection in terms of toxicity and antibiotic resistance

Nakayama

Ito

Nomura

et al. 2006

FEMS Microbiology Letters

View full text Add to dashboard Cite

Vibrio harveyi strains isolated from shrimp farms (wild strains) were compared with those from culture collections in terms of minimum inhibitory concentration (MIC) and toxicity. Wild strains had higher MIC values for four antibiotics (kanamycin, carbenicillin, oxytetracycline and ampicillin) and also showed higher toxicity compared with culture collection strains. Vibrio harveyi with the lowest antibacterial resistance was chosen to test if a gradual increase in antibiotic concentration and frequent subculture would enhance its antibiotic resistance. Results showed that V. harveyi was able to develop resistance to oxytetracycline. The MIC value was 250 times higher compared with the MIC before subculturing. Moreover, the V. harveyi strain developed slightly higher toxicity. Therefore, it is possible that there is a relationship between antibiotic resistance and toxicity in V. harveyi.

show abstract

Section: Discussionmentioning

confidence: 99%

Comparison ofVibrio harveyistrains isolated from shrimp farms and from culture collection in terms of toxicity and antibiotic resistance

Nakayama

Ito

Nomura

et al. 2006

FEMS Microbiology Letters

View full text Add to dashboard Cite

show abstract

“…Oxytetracycline can diffuse through pores in the cell membrane of Gram‐negative bacteria (general diffusion porins) as result of its hydrophilic character (Delcour ) and molecular weight lower than 500 Daltons (Chopra & Howe ). OTC acts as inhibitor of protein synthesis at the level of translation, reacting with the ribosome‐messenger (mRNA) complex (Dixon ).…”

Section: Use Of Oxytetracycline In Farmed Fishmentioning

confidence: 99%

Oxytetracycline in intensive aquaculture: water quality during and after its administration, environmental fate, toxicity and bacterial resistance

Leal

Santos

Esteves

2018

Reviews in Aquaculture

View full text Add to dashboard Cite

Oxytetracycline (OTC) is one of the most used antibiotics in aquaculture. This raises concerns due to its effects in human and animal health, the environmental contamination and the consequences arising therefrom. This review focuses on the OTC application in intensive aquaculture. It compiles and complements the dispersed information, presenting a comprehensive study about the OTC effects, from its administration to farmed fish, until its release into the surrounding aquatic systems. Several topics about OTC are presented and discussed: physicalchemical properties, interaction with ions, application to farmed fish, effects in water quality and possible treatments, biological activity and toxicity of OTC byproducts, environmental fate. Based on the information gathered, one concludes that OTC establishes strong complexes with Ca 2+ and Mg 2+ , which may have implications on its biological activity. OTC acts as inhibitor of protein synthesis and is poorly metabolized or unmetabolized by fish. Its common recommended daily dose is about 75 mg kg À1 but depends on the administration conditions and on target fish species. Regarding OTC removal from water within a semiclosed aquaculture's water circuit, ozonation and photodegradation are not completely efficient methods as none of them promotes total mineralization. However, photodegradation can be applied as a complementary method prior to ozonation, allowing to reduce costs. OTC by-products do not appear to retain its biological activity, but toxicity studies mimicking environmental conditions were not found. In open circuits (cages), water column where OTC is administered not suffer a specific treatment and the antibiotic is easily spread by the surrounding environments, affecting their inhabitants. OTC is released in the aquatic system in freely dissolved form and/or associated with organic or inorganic compounds, being subjected to natural photolysis, hydrolysis and/or biodegradation.

show abstract

“…Minocycline is a hydrophobic derivative of tetracycline [24], which is more efficient antibiotic against tetracycline resistant organisms than tetracycline and the other derivatives. The tet(B) gene confers moderate resistance to minocycline, whereas tet(K) gene confers only very low resistance [21].…”

Section: Minocycline Transport Mediated By the Vesicles Containing Tementioning

confidence: 99%

The tetracycline efflux protein encoded by the tet(K) gene from Staphylococcus aureus is a metal‐tetracycline/H⁺ antiporter

et al. 1995

View full text Add to dashboard Cite

Bacterial resistance to the tetracyclines.

Cited by 60 publications

References 95 publications

Comparison ofVibrio harveyistrains isolated from shrimp farms and from culture collection in terms of toxicity and antibiotic resistance

Comparison ofVibrio harveyistrains isolated from shrimp farms and from culture collection in terms of toxicity and antibiotic resistance

Oxytetracycline in intensive aquaculture: water quality during and after its administration, environmental fate, toxicity and bacterial resistance

The tetracycline efflux protein encoded by the tet(K) gene from Staphylococcus aureus is a metal‐tetracycline/H⁺ antiporter

Contact Info

Product

Resources

About

Bacterial resistance to the tetracyclines.

Cited by 60 publications

References 95 publications

Comparison ofVibrio harveyistrains isolated from shrimp farms and from culture collection in terms of toxicity and antibiotic resistance

Comparison ofVibrio harveyistrains isolated from shrimp farms and from culture collection in terms of toxicity and antibiotic resistance

Oxytetracycline in intensive aquaculture: water quality during and after its administration, environmental fate, toxicity and bacterial resistance

The tetracycline efflux protein encoded by the tet(K) gene from Staphylococcus aureus is a metal‐tetracycline/H+ antiporter

Contact Info

Product

Resources

About

The tetracycline efflux protein encoded by the tet(K) gene from Staphylococcus aureus is a metal‐tetracycline/H⁺ antiporter