Bacterial septic arthritis infections associated with intra-articular injection practices for osteoarthritis knee pain—New Jersey, 2017

Ross, Kathleen; Mehr, Jason; Carothers, Barbara; Greeley, Rebecca; Benowitz, Isaac; Henry, David H.; McHugh, Lisa; DiFedele, Lisa; Adler, Eric; Naqvi, Shereen; Taylor, Laura; Lifshitz, Edward; Tan, Christina; Montana, Barbara

doi:10.1017/ice.2019.168

Cited by 14 publications

(9 citation statements)

References 13 publications

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“…Moreover, 43.3% had more than 10 years of experience in rheumatology practice. The median of interventional procedures was 5 [2][3][4][5][6][7][8] per week. All the participants performed interventional procedures on superficial joints, whereas profound joint procedures and epidural injections were performed only by 19.2% and 14.4% of participants, respectively and periarticular injections by 86.5% of participants.…”

Section: Interventional Proceduresmentioning

confidence: 99%

“…1 It is an uncommon but life-threatening disease that may be induced by a breach in the aseptic technique, while performing an intra-articular procedure. 2 Intra-articular injections have become widespread all over the world, since their introduction into rheumatologic practice by Hollander in the 1950s. 3 They are used for both diagnostic and therapeutic purposes.…”

Section: Introductionmentioning

confidence: 99%

“…If the rules of asepsis are not respected, the consequences will be catastrophic for the patient who develops a iatrogenic life threatening septic arthritis and consequently for the physician who can face serious legal problems regarding his direct responsibility. 2 However, in the literature, data about specific precautions that should be taken to avoid iatrogenic septic arthritis are scarce.…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of aseptic technique used in interventional rheumatology: survey among Moroccan and Tunisian rheumatologists

et al. 2021

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The objective of our study was to evaluate the aseptic technique used in interventional rheumatology by Moroccan and Tunisian rheumatologists. We performed an online survey among rheumatologists from Morocco and Tunisia. The questionnaire included 15 questions with single and multiple-choice answers and three open sections for freetext comments. An online survey was prepared and sent to 380 rheumatologists. One hundred and four rheumatologists (27.36%) replied to the survey. More than half of the participants (56.7%) were from Tunisia and 43.3% were from Morocco. Interventional procedures on superficial joints were performed by all participants. Ultrasonography was used by 41.3% of respondents to guide interventional procedures. Regarding the aseptic precautions taken to avoid infection, the majority of participants used povidone iodine to clean the skin and only 8.7% wore a mask. Hand washing alone without gloves wearing was done by 19.2% of participants. 2.9% of participants reported a history of iatrogenic septic arthritis and the duration of practice was the only factor associated with its occurrence (P=0.007). Our study showed that aseptic technique used during interventional rheumatologic procedures is heterogeneous. However, the majority of participants were aware of its necessity to avoid iatrogenic septic arthritis.

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Section: Interventional Proceduresmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Evaluation of aseptic technique used in interventional rheumatology: survey among Moroccan and Tunisian rheumatologists

et al. 2021

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“…However, outbreaks associated with injection safety breaches have been reported. Examples of such breaches include using the same syringe to deliver medication to more than one patient, using single-dose or single-use medications for more than one patient, and failing to use an aseptic technique when preparing and administering injections [3].…”

Section: Pathophysiologymentioning

confidence: 99%

Native Joint Bacterial Septic Arthritis in the Adult

Segreti¹

2021

PPID

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Septic arthritis (SA) is an uncommon but potentially life-threatening condition; it occurs when microorganisms invade the joint space by direct inoculation or by hematogenous spread. Up to a third of patients with septic arthritis suffer long-term disability. Challenges in the management of septic arthritis include selection of appropriate antimicrobials and selection of an appropriate joint fluid drainage method [1]. In this review, I will focus on the epidemiology, mechanism, pathogenesis, clinical signs, diagnosis, and treatment of native joint bacterial septic arthritis in the adult.

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“…One of the most commonly associated pathogens with bone infection is Staphylococcus aureus (S. aureus), and such infections clinically manifest in the form of osteomyelitis, orthopedic prosthetic infections, and septic bacterial arthritis [1][2][3][4][5][6]. S. aureus infections result in foot ulcers, which are common in immune-compromised diabetic patients due to hyperglycemia, and chronic osteomyelitis may result in amputation of associated limbs [7,8].…”

Section: Introductionmentioning

confidence: 99%

Boron doped silver-copper alloy nanoparticle targeting intracellular S. aureus in bone cells

et al. 2020

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ObjectivesAlloyed metallic nanoparticles of silver and copper are effective against intracellular infection. However, systemic toxicity may arise due to the non-specific delivery of the nanoparticles. In addressing the issue, this study deals with the targeting of silver-copper-boron (ACB) nanoparticles to infected osteoblasts, which could decrease systemic toxicity and form the basis of targeting specific markers expressed in bone infections. MethodsACB nanoparticles were synthesized and conjugated to the Cadherin-11 antibody (OBAb). The effect of targeting nanoparticles against extracellular and intracellular S. aureus was determined by enumeration of bacterial growth. The binding of the targeting nanoparticles to infected osteoblasts as well as the visualization of live/dead bacteria due to treatment was carried out using fluorescence microscopy. MTT assay was used to determine the viability of osteoblasts with different concentrations of the nanoparticles. ResultsThe ACB nanoparticles conjugated to OBAb (ACB-OBAb) were effective against extracellular S. aureus. The ACB-OBAb nanoparticles showed a 1.32 log reduction of intracellular S. aureus at a concentration of 1mg/L. The ACB-OBAb nanoparticles were able to bind to the infected osteoblast and showed toxicity to osteoblasts at levels �20mg/L. Also, the percentage of silver, copper, and boron in the nanoparticles determined the effectiveness of their antibacterial activity. ConclusionThe ACB-OBAb nanoparticles were able to target the osteoblasts and demonstrated significant antibacterial activity against intracellular S. aureus. Targeting shows promise as a strategy to target specific markers expressed on infected osteoblasts for efficient

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Bacterial septic arthritis infections associated with intra-articular injection practices for osteoarthritis knee pain—New Jersey, 2017

Cited by 14 publications

References 13 publications

Evaluation of aseptic technique used in interventional rheumatology: survey among Moroccan and Tunisian rheumatologists

Evaluation of aseptic technique used in interventional rheumatology: survey among Moroccan and Tunisian rheumatologists

Native Joint Bacterial Septic Arthritis in the Adult

Boron doped silver-copper alloy nanoparticle targeting intracellular S. aureus in bone cells

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