Bacterial targeted tumour therapy-dawn of a new era

Wei, Ming; Mengesha, Asferd; Good, David A.; Anné, Jozef

doi:10.1016/j.canlet.2007.10.034

Cited by 145 publications

(138 citation statements)

References 53 publications

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“…6 The historical development and molecular mechanisms of anaerobic bacteria as tumor targeting vectors are reviewed in detail elsewhere. 5,[7][8][9] The concept of bacterial oncolytic therapy has been verified in numerous experimental, as well as clinical studies. Recently, a tumortargeting auxotrophic strain of Salmonella typhimurium has been shown to completely eradicate primary tumors, as well as cancer metastases in various mouse models.…”

Section: Introductionmentioning

confidence: 99%

Gene therapy for cancer: bacteria-mediated anti-angiogenesis therapy

et al. 2011

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Several bacterial species have inherent ability to colonize solid tumors in vivo. However, their natural anti-tumor activity can be enhanced by genetic engineering that enables these bacteria express or transfer therapeutic molecules into target cells. In this review, we summarize latest research on cancer therapy using genetically modified bacteria with particular emphasis on blocking tumor angiogenesis. Despite recent progress, only a few recent studies on bacterial tumor therapy have focused on anti-angiogenesis. Bacteria-mediated anti-angiogenesis therapy for cancer, however, is an attractive approach given that solid tumors are often characterized by increased vascularization. Here, we discuss four different approaches for using modified bacteria as anti-cancer therapeutics-bactofection, DNA vaccination, alternative gene therapy and transkingdom RNA interference-with a specific focus on angiogenesis suppression. Critical areas and future directions for this field are also outlined.

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Section: Introductionmentioning

confidence: 99%

Gene therapy for cancer: bacteria-mediated anti-angiogenesis therapy

et al. 2011

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“…These types of drug rely on the hypoxia-induced bio-reduction of a pro-drug to an active form. Other groups are investigating the potential of recombinant anaerobic bacteria [49,50] that become active only in regions of very low PO 2 and may be directly oncolytic or vectors for the delivery of therapeutic genes. Another possibility is to target the HIF-1 signal transduction pathway and a variety of approaches aimed at either inhibition of HIF-1 activation or HIF-1 target genes are under investigation [41] .…”

Section: Novel Therapeutic Strategies For Micro-metastasesmentioning

confidence: 99%

“…To this list, one could speculatively add the possibility of a therapeutic variant of a hypoxia imaging tracer. For example, a hypoxia-selective molecule labeled with an alpha-particle emitting radionuclide with a relatively short half-life may be attractive since the cytotoxic effect of alpha-particles is not modified by the absence of oxygen [51] .…”

Section: Novel Therapeutic Strategies For Micro-metastasesmentioning

confidence: 99%

Understanding hypoxia microenvironment of micrometastases

Jiang

2012

JST

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Most cancer-related deaths are due to the development of metastatic disease rather than the growth of primary tumors. Adjuvant treatment often does not translate into substantial improvements in overall survival; subclinical micrometastases may be resistant to multiple therapies. Understanding microenvironment factors such as hypoxia, proliferation and glucose metabolism in micro-metastases is of importance for micro-metastases treatment; hypoxia, commonly observed in most primary solid malignancies, is associated with tumor progression, increased aggressiveness, enhanced metastatic potential and poor prognosis and hypoxic tumor cells are more resistant to radiotherapy and some forms of chemotherapy. In this article, we discussed hypoxia status of micro-metastases, and related this to cellular proliferation and glucose metabolism. We also proposed hypoxia as a therapeutic target for micro-metastases.

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“…En 1813 Vautier comprobó, accidentalmente, que pacientes que padecían cáncer y habían desarrollado gangrena gaseosa por una infección con Clostrididum perfringens mejoraban, observándose en ellos una regresión del tumor que sugería estar relacionada con la bacteria, Wei et al, (2008a). En 1868 el físico alemán W. Busch indujo una infección por Streptococcus pyogenes en una paciente con cáncer, poniéndola en una cama previamente ocupada por un paciente que padecía erisipela, observando una mejoría.…”

Section: Utilización De Microorganismos En El Tratamiento De Tumores unclassified

Esporos bacterianos para el tratamiento del cáncer.

González¹,

Lencioni²,

Jiménez³

et al. 2012

Revista Complutense De Ciencias Veterinarias

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RESUMENLos métodos utilizados actualmente en el tratamiento del cáncer son todavía muy lesivos para el organismo y en muchas ocasiones poco efectivos. Los tumores sólidos con zonas de hipoxia presentan los mayores inconvenientes para su resolución. En las investigaciones sobre alternativas para su tratamiento, son muchos científicos los que apuestan por el uso de bacterias y por sus formas de resistencia, los esporos.Diferentes investigaciones realizadas han comprobado las ventajas del empleo de esporos bacterianos (Clostridium novyi-NT, Clostridium sporogenes ATCC13732, y Clostridium beijerinckii NCIMB 8052). Se caracterizan por ser estables hasta alcanzar zonas con las condiciones concretas permisivas para su germinación (hipoxia), por lo que pueden ser administrados por vía sistémica. El efecto antitumoral producido se basa en la producción de enzimas hidrolíticas (proteasas, nucleasas y lipasas) y, en la competición entre la bacteria y las células neoplásicas por los nutrientes. Así mismo, mediante técnicas de modificación del genoma, se han podido suprimir los genes perjudiciales e insertar diversos genes y plásmidos terapéuticos de acción selectiva en el tumor. Y por último, pueden combinarse con otros tratamientos (COBALT combination bacteriolytic therapy).El uso de esporos modificados genéticamente supone un nuevo horizonte en el tratamiento del cáncer, sobre todo en regiones inaccesibles del tumor.Palabras clave: esporos, cáncer, Clostridium novyi -NT,

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Bacterial targeted tumour therapy-dawn of a new era

Cited by 145 publications

References 53 publications

Gene therapy for cancer: bacteria-mediated anti-angiogenesis therapy

Gene therapy for cancer: bacteria-mediated anti-angiogenesis therapy

Understanding hypoxia microenvironment of micrometastases

Esporos bacterianos para el tratamiento del cáncer.

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