Bacterial vaginosis and biomarkers of oxidative stress in amniotic fluid

Bogavac, Mirjana; Lakic, Neda; Simin, Nataša; Nikolić, Aleksandra; Sudji, Jan; Božin, Biljana

doi:10.3109/14767058.2011.614660

Cited by 7 publications

(7 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Results of other researches indicate the role of local immunological factors, genetically predisposed and depending on their presentation to microorganisms causing BV, local inflammatory mediators such as cytokines, chemokines, and growth factors that determine what kind of consequences will appear. It is also assumed that the increased production of local cytokinesprostaglandins, can trigger preterm delivery [29][30][31][32] .…”

Section: Discussionmentioning

confidence: 99%

The influence of bacterial vaginosis on gestational week of the completion of delivery and biochemical markers of inflammation in the serum

et al. 2014

Self Cite

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

The influence of bacterial vaginosis on gestational week of the completion of delivery and biochemical markers of inflammation in the serum

et al. 2014

Self Cite

View full text Add to dashboard Cite

show abstract

“…OxS is known to be one of the possible factors causing infertility by affecting oocyte quality, fertilization, early embryo development, implantation and pregnancy rates [25][26][27][28]. Endometriosis has been shown to be associated with higher lipid peroxidation and DNA damage [29] while bacterial vaginosis with high grade OxS levels and adverse pregnancy outcome [30]. OxSrelated DNA damage has been identified as a major contributor to poor ART outcomes, including impaired embryo development, miscarriage and birth defects in the offspring [6,12].…”

Section: -Epi (8-iso Prostaglandin F 2α ) 8-ohdg (8-hydroxy-2'-deoxmentioning

confidence: 99%

Systemic oxidative stress could predict assisted reproductive technique outcome

Ahelik

Mändar

Korrovits

et al. 2015

J Assist Reprod Genet

View full text Add to dashboard Cite

Purpose Previous studies have indicated that OxS (oxidative stress) may appear as a possible reason for poor ART outcome. Our aim was to study OxS levels in both partners of couples seeking Assisted reproduction Technology (ART). Methods Altogether 79 couples were recruited. Oxidative DNA damage (8-OHdG) and lipid peroxidation (8-EPI) were measured, and clinical background and ART outcomes were recorded. Results Both OxS markers accurately reflected clincal conditions with prominent negative effects attributable to genital tract infections, endometriosis, uterine myoma and smoking. Furthermore, the level of OxS was also affected by partner's state of health. The highest 8-EPI levels were detected in both partners when biochemically detectable pregnancies did not develop into clinically detectable pregnancies (in women, 97, 8±16,7 vs 72.9±22,9, p=0.007; in men, 89.6±20,4 vs 72,1± 22,6, p=0.049). Conclusions To conclude, high grade systemix OxS in both partners may negatively affect the maintenance and outcome of pregnancy. Applying the detection of OxS in ART patients may select patients with higher success rate and/or those who require antioxidant therapy. This would lead to improvement of ART outcome as well as natural fertility.

show abstract

“…The primary antioxidant system protection consists of many enzymes such as superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px), which are the first line of defense of the organism and catalyze the removal of toxic forms of oxygen in cells 5,6 . SOD catalyzes the dismutation reaction of superoxide anion radicals…”

Section: Introductionmentioning

confidence: 99%

Preeclampsia and level of oxidative stress in the first trimester of pregnancy

Bogavac¹,

Jakovljevic²,

Stajic

et al. 2017

VSP

Self Cite

View full text Add to dashboard Cite

Background/Aim. Preeclampsia (PE) is a multisystemic syndrome that complicates 5-8% of all pregnancies. The aim of this study was to evaluate the biochemical parameters of oxidative stress in the first trimester of pregnancy in patients with preeclampsia, with the purpose of comparing the level of oxidative stress with normal pregnancy. Methods. The study was conducted as a prospective study. It included totally 107 pregnant women divided into two groups. In the study group (n = 33) there were women who developed preeclampsia in the current pregnancy. The control group (n = 74) included healthy pregnant women. Blood samples were taken between 11th and 14th weeks of gestation, and the values of superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and total antioxidant status (TAS) were determined in serum by enzymatic colorimetric methods. Results. The values of SOD and GHS-Px were statistically higher in the study group, while the values of TAS were statistically higher in the control group. The level of TAS inversely correlated with GSH-Px and SOD, but there is no statistically significant correlation between GSH-Px and SOD in the study group. Conclusion. The results of this study suggest a higher level of oxidative stress in the first trimester of pregnancy with preeclampsia, which may indicate that the initiation and development of pathophysiological processes underlying preeclampsia start much earlier than the clinical syndrome exhibit.

show abstract

Bacterial vaginosis and biomarkers of oxidative stress in amniotic fluid

Abstract: Although, biomarkers of antioxidant activity are present in the amniotic fluid, they are not different between women with and without bacterial vaginosis.

Cited by 7 publications

References 24 publications

The influence of bacterial vaginosis on gestational week of the completion of delivery and biochemical markers of inflammation in the serum

The influence of bacterial vaginosis on gestational week of the completion of delivery and biochemical markers of inflammation in the serum

Systemic oxidative stress could predict assisted reproductive technique outcome

Preeclampsia and level of oxidative stress in the first trimester of pregnancy

Contact Info

Product

Resources

About