Bacterial Vaginosis and Vaginal Yeast, But Not Vaginal Cleansing, Increase HIV-1 Acquisition in African Women

Wijgert, Janneke van de; Morrison, Charles; Cornelisse, Peter; Munjoma, Marshall; Moncada, Jeanne; Awio, P; Wang, Jing; Pol, Barbara Van Der; Chipato, Tsungai; Salata, Robert A.; Padian, Nancy

doi:10.1097/qai.0b013e3181743936

Cited by 116 publications

(111 citation statements)

References 25 publications

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“…The estrogen increases the glycogen content of vaginal epithelial cell activity; in turn inhibiting the in vitro growth of certain bacteria, which may result in low risk for bacterial vaginosis [19]. Our findings were supported with previous studies done in population of UK [27], Sweden [39], Netherlands [40], USA [20,41,42], turkey [43].…”

Section: Discussionsupporting

confidence: 82%

Factor Associated to Bacterial Vaginosis in Non-pregnant Women of North Indian Population

Amita¹,

Nain²

2015

J Biotechnol Biomater

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Bacterial vaginosis is currently the most prevalent cause of vaginal infection and vaginal discharge among the sexually active women. Bacterial vaginosis is a complex microbiological disease. Therefore, we aimed to determine the association of risk factors for bacterial vaginosis patients. In the prospective study, we enrolled a total of 300 nonpregnant women. One hundred and twenty six women were positive for bacterial vaginosis, confirmed by Amsel's criteria and Nugent's scoring. One hundred and seventy four women were unrelated control. Frequency of intrauterine contraceptive device differed significantly between bacterial vaginosis and healthy individuals (29.4% versus 17.2%, p=0.017; OR=1.70). Individuals with a sexual transmitted disease in partners was conferred significantly higher risk for bacterial vaginosis (p=0.001, OR=8.28). However, use of contraception, vaginal douching, and use of condom did not modulate the risk of bacterial vaginosis. Individuals with the use of intrauterine contraceptive device and presence of sexual transmitted disease in partners conferred a higher risk for bacterial vaginosis.

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Section: Discussionsupporting

confidence: 82%

Factor Associated to Bacterial Vaginosis in Non-pregnant Women of North Indian Population

Amita¹,

Nain²

2015

J Biotechnol Biomater

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“…Current epidemiological evidence using the above-mentioned diagnostic methods also suggests that any deviation from a lactobacilli-dominated cervicovaginal microbiome increases women's susceptibility to HIV and, in HIVpositive women, genital HIV shedding (Sha et al, 2005;van de Wijgert et al, 2008;Hayes et al, 2010). Furthermore, relationships between BV by Nugent scoring and herpes simplex virus type 2 (HSV-2; Cherpes et al, 2003), Neisseria gonorrhoeae, Chlamydia trachomatis (Wiesenfeld et al, 2003) and Trichomonas vaginalis (Rathod et al, 2011) have been described.…”

Section: Introductionmentioning

confidence: 99%

Lactobacillus-dominated cervicovaginal microbiota associated with reduced HIV/STI prevalence and genital HIV viral load in African women

Tsivtsivadze²,

et al. 2014

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Cervicovaginal microbiota not dominated by lactobacilli may facilitate transmission of HIV and other sexually transmitted infections (STIs), as well as miscarriages, preterm births and sepsis in pregnant women. However, little is known about the exact nature of the microbiological changes that cause these adverse outcomes. In this study, cervical samples of 174 Rwandan female sex workers were analyzed cross-sectionally using a phylogenetic microarray. Furthermore, HIV-1 RNA concentrations were measured in cervicovaginal lavages of 58 HIV-positive women among them. We identified six microbiome clusters, representing a gradient from low semi-quantitative abundance and diversity dominated by Lactobacillus crispatus (cluster R-I, with R denoting 'Rwanda') and L. iners (R-II) to intermediate (R-V) and high abundance and diversity (R-III, R-IV and R-VI) dominated by a mixture of anaerobes, including Gardnerella, Atopobium and Prevotella species. Women in cluster R-I were less likely to have HIV (P ¼ 0.03), herpes simplex virus type 2 (HSV-2; Po0.01), and high-risk human papillomavirus (HPV; Po0.01) and had no bacterial STIs (P ¼ 0.15). Statistically significant trends in prevalence of viral STIs were found from low prevalence in cluster R-I, to higher prevalence in clusters R-II and R-V, and highest prevalence in clusters R-III/R-IV/R-VI. Furthermore, only 10% of HIV-positive women in clusters R-I/R-II, compared with 40% in cluster R-V, and 42% in clusters R-III/ R-IV/R-VI had detectable cervicovaginal HIV-1 RNA (P trend ¼ 0.03). We conclude that L. crispatusdominated, and to a lesser extent L. iners-dominated, cervicovaginal microbiota are associated with a lower prevalence of HIV/STIs and a lower likelihood of genital HIV-1 RNA shedding.

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“…It could be argued that there is little value in characterizing the less dominant species; however, the etiology and ecology of BV are complex and poorly understood (27). We do not know what initiates the changes in microbial populations as they transition from healthy to abnormal compositions, what causes refractory or recurrent responses to treatment, whether there is a sexual transmission component, or whether specific compositions pose higher risks for the complications associated with BV in general (28)(29)(30)(31)(32)(33). It could also be argued that effective treatment of BV Escherichia coli ␥-P 36 Aggregatibacter ␥-P 37…”

Section: Figmentioning

confidence: 99%

Novel PCR-Based Methods Enhance Characterization of Vaginal Microbiota in a Bacterial Vaginosis Patient before and after Treatment

Lambert

Kalra

Dodge

et al. 2013

Appl Environ Microbiol

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bDeep characterization, even by next-generation sequencing, of the vaginal microbiota in healthy women or posttreatment bacterial vaginosis patients is limited by the dominance of lactobacilli. To improve detection, we offer two approaches: quantitative PCR (qPCR) using phylogenetic branch-inclusive primers and sequencing of broad-spectrum amplicons generated with oligomers that block amplification of lactobacilli.

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Bacterial Vaginosis and Vaginal Yeast, But Not Vaginal Cleansing, Increase HIV-1 Acquisition in African Women

Abstract: BV and yeast may contribute more to the HIV epidemic than previously thought.

Cited by 116 publications

References 25 publications

Factor Associated to Bacterial Vaginosis in Non-pregnant Women of North Indian Population

Factor Associated to Bacterial Vaginosis in Non-pregnant Women of North Indian Population

Lactobacillus-dominated cervicovaginal microbiota associated with reduced HIV/STI prevalence and genital HIV viral load in African women

Novel PCR-Based Methods Enhance Characterization of Vaginal Microbiota in a Bacterial Vaginosis Patient before and after Treatment

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