Bacterial vaginosis as a risk factor for high‐grade cervical lesions and cancer in HIV‐seropositive women

Denslow, Sheri; Westreich, Daniel; Firnhaber, Cynthia; Michelow, Pam; Williams, Sophie; Smith, Jennifer S.

doi:10.1016/j.ijgo.2011.03.011

Cited by 8 publications

(3 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…A disruption of the vaginal microbial communities can lead to decreased immune protection, thereby increasing susceptibility of the epithelial lining of reproductive tissues to viral infections. The shift of microbial communities from those that are protective ( Lactobacillus genus) to those that are harmful anaerobic bacteria ( Gardenerella vaginalis, Atopobium vaginae, Mobiluncus and Prevotella species ), as occurs with BV, can damage the epithelial layer of reproductive tissues making it penetrable to viral entry, especially those viruses that are sexually transmitted (HIV and HPV) (Denslow et al, 2011 ; Mirmonsef et al, 2011 ). Importantly, infection with HIV or HPV is attributed to the development of several cancers including cervical cancer, Kaposi sarcoma, Non-Hodgkin lymphoma, ano-genital cancer, and cancers of the mouth and oropharynx (Parkin, 2006 ).…”

Section: Reproductive Tract Microbiomesmentioning

confidence: 99%

Individualized medicine and the microbiome in reproductive tract

et al. 2015

View full text Add to dashboard Cite

Humans have evolved along with the millions of microorganisms that populate their bodies. These microbes (1014) outnumber human cells by 10 to 1 and account for 3 × 106 genes, more than ten times the 25,000 human genes. This microbial metagenome acts as our “other genome” and like our own genes, is unique to the individual. Recent international efforts such as the Human Microbiome Project (HMP) and the MetaHIT Project have helped catalog these microbial genomes using culture-independent, high-throughput, next-generation sequencing. This manuscript will describe recent efforts to define microbial diversity in the female reproductive tract because of the impact that microbial function has on reproductive efficiency. In this review, we will discuss current evidence that microbial communities are critical for maintaining reproductive health and how perturbations of microbial community structures can impact reproductive health from the aspect of infection, reproductive cyclicity, pregnancy, and disease states. Investigations of the human microbiome are propelling interventional strategies from treating medical populations to treating individual patients. In particular, we highlight how understanding and defining microbial community structures in different disease and physiological states have lead to the discovery of biomarkers and, more importantly, the development and implementation of microbial intervention strategies (probiotics) into modern day medicine. Finally this review will conclude with a literature summary of the effectiveness of microbial intervention strategies that have been implemented in animal and human models of disease and the potential for integrating these microbial intervention strategies into standard clinical practice.

show abstract

Section: Reproductive Tract Microbiomesmentioning

confidence: 99%

Individualized medicine and the microbiome in reproductive tract

et al. 2015

View full text Add to dashboard Cite

show abstract

“…veya invaziv servikal kanser geliçimi ile yakin iliçkili oldugu dücünülmüctür (1,5,9,11,(16)(17)(18).…”

Section: Sonuçlarunclassified

The Influence of Cervicovaginitis Agents on Epithelial Cell Changes: Comparison of Mardin City's Data with the Literature

Bariş¹,

Keleş²,

Karakaya³

2012

TJPATH

View full text Add to dashboard Cite

show abstract

“…Whether HPV-positive women are more likely to develop BV is unclear (7) . Although an association between BV and HPV has been suggested, there is no evidence that BV increases the risk of squamous intraepithelial lesions (SILs) or cervical cancer (11)(12)(13) . Bacterial vaginosis seems to affect only the viral incidence and prevalence but not the persistence of HPV infection.…”

Section: Introductionmentioning

confidence: 99%

Influence of human papillomavirus infection on the vaginal microbiome of women with immunocompetency

Rebouças¹,

Eleutério²,

Eleutério³

et al. 2014

J bras doenças sex transm

View full text Add to dashboard Cite

Introduction:The influence of vaginal infections on the natural history of human papillomavirus (HPV) is still unclear. Objective: To determine if patients with low-grade squamous intraepithelial lesions (LSILs) and HPV have more vulvovaginitis than patients with normal liquid-based cervical cytology who were negative for HPV. Methods: This is a cross-sectional study including 322 patients who underwent cervical exams. One hundred and sixty-seven of these patients had LSILs on cervical cytology and were simultaneously hybrid capture 2 (HC2)-positive for HPV, and the remaining 155 patients were negative for malignancies and intraepithelial lesions by cytology and HC2-negative for HPV. The prevalence of vaginal infections in both groups was compared using the χ 2 test without Yates' correction. Results: Among the patients with HPV and LSILs, the most common vaginal infection was vaginosis (8.98%) compared to candidiasis (12.9%) in the patients without LSILs and HPV. No significant differences were found in the prevalence of vaginosis between the two groups (p=0.53). Candidiasis was statistically more prevalent in patients without LSILs and HPV (p<0.001). Conclusion: An association was found between the presence of Candida and the absence of HPV. Although vaginosis was more frequent among patients with LSILs and HPV, it was not statistically significant.

show abstract

Bacterial vaginosis as a risk factor for high‐grade cervical lesions and cancer in HIV‐seropositive women

Cited by 8 publications

References 21 publications

Individualized medicine and the microbiome in reproductive tract

Individualized medicine and the microbiome in reproductive tract

The Influence of Cervicovaginitis Agents on Epithelial Cell Changes: Comparison of Mardin City's Data with the Literature

Influence of human papillomavirus infection on the vaginal microbiome of women with immunocompetency

Contact Info

Product

Resources

About