Bacterial vaginosis: Standard treatments and alternative strategies

Tomás, Mariana; Palmeira‐de‐Oliveira, Ana; Simões, Sérgio; Martinez-de-Oliveira, José; Palmeira‐de‐Oliveira, Rita

doi:10.1016/j.ijpharm.2020.119659

Cited by 59 publications

(52 citation statements)

References 98 publications

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“…Treatment of bacterial vaginosis is based on the oral or vaginal administration of antibiotics, such as clindamycin and metronidazole [7]. However, some problems have been pointed out that frequent relapses occur after antibiotic treatment, and beneficial bacteria are killed.…”

Section: Introductionmentioning

confidence: 99%

Design and Medical Effects of a Vaginal Cleaning Device Generating Plasma-Activated Water with Antimicrobial Activity on Bacterial Vaginosis

Hwang¹,

Jeon²,

Wang³

et al. 2020

Plasma

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Bacterial vaginosis is a common female disease caused by a vaginal infection due to an overgrowth of bacteria that naturally live in the vaginal tract. Bacterial vaginosis has frequently been treated with the oral or vaginal administration of antibiotics and topical disinfectants. However, hygienic application of topical treatment deep in the vagina remains difficult. Herein, we introduce a novel vaginal cleaning device using plasma-activated water generated from supplied water. Remarkably, plasma source generation at atmospheric pressure is well known to eradicate bacterial infection through the generation of free radicals and/or chlorine chemicals with antimicrobial activity. The device was designed to alleviate a bacterial infection by spraying plasma-activated water generated from a cleaning solution container with plasma modules. The spray nozzle contains both a clean outlet and a suction outlet to spray and recover the plasma water, respectively, and is connected to a disposable silicone tube. The other nozzle, which has a laser light and air pump, can perform a second sterilization and dry the vagina after washing. Free chlorine chemicals with antibacterial activity were detected in the plasma-activated water by the device. Clinical application in patients with bacterial vaginosis confirmed the stability and effectiveness of our device. Therefore, these results show a novel clinical application of atmospheric pressure plasma to medical field as a plasma medicine.

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Section: Introductionmentioning

confidence: 99%

Design and Medical Effects of a Vaginal Cleaning Device Generating Plasma-Activated Water with Antimicrobial Activity on Bacterial Vaginosis

Hwang¹,

Jeon²,

Wang³

et al. 2020

Plasma

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“…But, regrettably, the cure rates associated with MTD ranged from 50–80%, with a high recurrence rate (Schwebke & Desmond, 2011 ). One of the main reasons for treatment failure is vaginal biofilm which plays a key role not only in BV pathogenesis but also in its recurrence (Tomás et al., 2020 ). Bacterial biofilms are established when an accumulation of adherent microorganisms occurs on a living surface (Malaekeh-Nikouei et al., 2020 ).…”

Section: Resultsmentioning

confidence: 99%

“…The biofilm’s structure avoids the antimicrobial penetration in the matrix as well as the direct contact with the microorganisms. Concurrently, an increase in antibiotics resistance is detected, which leads to treatment failures (Tomás et al., 2020 ). Several studies recommend the lack of effectiveness of conventional antimicrobial treatments and high recurrence rates of BV because of their failure to destroy the vaginal biofilm in addition to their adverse effects on healthy vaginal microflora (Tomás et al., 2020 ).…”

Section: Resultsmentioning

confidence: 99%

Clinical comparative study of optimized metronidazole loaded lipid nanocarrier vaginal emulgel for management of bacterial vaginosis and its recurrence

et al. 2021

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“…Хоча протягом багатьох років одним із препаратів вибору для патогенетично обумовленого лікування бактеріального вагінозу залишається кліндаміцин [14,19,21,43], проте дослідження його фармакокінетики при місцевому введення у формі супозиторіїв демонструє широкий діапазон значень фармакокінетичних показників. На нашу думку, причиною даного феномену можуть бути певні ендогенні чинники, які варіюють у різних жінок.…”

Section: вступunclassified

“…Протягом багатьох років одним із препаратів вибору для патогенетично обумовленого лікування бактеріального вагінозу залишається кліндаміцин [14,19,21,43].…”

Section: бактеріальній вагінозunclassified

Intravaginal use of clindamycin phosphate in therapy of bacterial vaginosis: peculiarities of pharmacokinetics depending on the level of hydrogen sulfide in the organism (literature review)

Гребенюк¹,

Таран²,

Назарчук³

2020

Rep. of Vinnytsia Nation. Med. Univ.

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Annotation. The article provides an overview of modern literature data on the problems of bacterial vaginosis, its therapy with clindamycin, the pharmacokinetics of this pharmacological drug, and the potential effect of the background level of hydrogen sulfide in the body on the pharmacokinetics of drugs. From PubMed, ScienceDirect, UpToDate databases, 50 sources were selected that met the conditions of the query: the latest publications (for the last 5 years), or the latest publications on this issue (regardless of age). The wide and diverse influence of endogenous hydrogen sulfide on the course of biochemical and physiological processes in the body prompts the study of its potential modulating effect on the pharmacological properties of drugs. A preclinical study of the pharmacokinetics and pharmacodynamics of drugs (in particular, clindamycin) will further optimize therapeutic regimens taking into account the level of hydrogen sulfide in the body, as well as create the preconditions for the development of new effective pharmaceutical compositions of antibiotics and hydrogen sulfide donors.

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Bacterial vaginosis: Standard treatments and alternative strategies

Cited by 59 publications

References 98 publications

Design and Medical Effects of a Vaginal Cleaning Device Generating Plasma-Activated Water with Antimicrobial Activity on Bacterial Vaginosis

Design and Medical Effects of a Vaginal Cleaning Device Generating Plasma-Activated Water with Antimicrobial Activity on Bacterial Vaginosis

Clinical comparative study of optimized metronidazole loaded lipid nanocarrier vaginal emulgel for management of bacterial vaginosis and its recurrence

Intravaginal use of clindamycin phosphate in therapy of bacterial vaginosis: peculiarities of pharmacokinetics depending on the level of hydrogen sulfide in the organism (literature review)

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