Bactericidal Activities of Radical Species Generated by Catalytic Reaction of Iron(III) Octacarboxyphthalocyanine

Abstract

<jats:p> Strong bactericidal activities against various bacteria were observed in the reaction system of iron(III) octacarboxyphthalocyanine ( Fe <jats:sup> III </jats:sup>- oapc ) and tert-butyl hydroperoxide (tert-BuOOH). The kinetics of the decomposition of tert-BuOOH catalysed by Fe <jats:sup> III </jats:sup>-oapc were studied in buffered solutions between pH 5 to 12 using gas chromatography analysis. The rate of catalytic decomposition of tert-BuOOH followed second-order kinetics in tert-BuOOH concentrations. The second-order rate constant (k<jats:sub>2</jats:sub>) had a maximum value at pH 11. Oxygen evolution was observed at high tert-BuOOH concentration, while oxygen consumption was observed at low tert-BuOOH concentration. The former indicates plural radical chain reactions of the tert-butoxyl radical and the latter suggests decomposition of the tert-butoxyl radical to acetone and methyl radical. By the electron spin resonance spin trapping method using 5,5-dimethyl-1-pyrroline-N-oxide and α-phenyl-N-tert-butylnitrone it was found that the radical species generated in the reaction system is tert-butoxyl radical, which plays crucial roles in bactericidal activities. </jats:p>

“Green” Oxidation Catalysis for Rapid Deactivation of Bacterial Spores

“…form during the reaction: one path of their decomposition involves the formation of the methyl radical and acetone 24 . tert ‐Butoxyl radicals have been reported to yield bactericidal activity 24. This bactericidal activity is in addition to that of the “membrane‐active” CTAB.…”

Synthesis, structure and properties of coordination compounds of iron phthalocyanines and their analogues

“…21,227,228 In addition, high antihistamine and antiserotonin activities of PcFe derivatives were observed in a number of studies. 5,229 The use of these compounds as deodorising agents is based on their high oxidase activity. 230 Semiconducting properties of iron phthalocyanines and their analogues have received little use.…”