Bactericidal Activity and Toxicity of Iodine-Containing Solutions in Wounds

Rodeheaver, George T.

doi:10.1001/archsurg.1982.01380260051009

Cited by 170 publications

(42 citation statements)

References 6 publications

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“…16,37 Just over a third of the dogs in our study developed cutaneous skin reactions following the initial wash with the neutral detergent. Contact dermatitis has been correlated with a rise in post-surgical wound infections in humans 104 and similar findings have been suggested in the veterinary literature. 18 One explanation is that surface bacteria multiply more rapidly on irritated, damaged or diseased skin.…”

supporting

confidence: 75%

Comparative efficacy of three antiseptics as surgical skin preparations in dogs

Boucher

Henton²,

Becker

et al. 2018

Veterinary Surgery

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Objective To compare the antimicrobial efficacy of a 2% chlorhexidine gluconate and 70% ethanol solution (CG+A) with that of F10 Skin Prep Solution (F10) and electrochemically activated water (EAW) when used as a surgical preparation in canine patients. Study design Prospective randomized clinical study. Sample population One hundred sixteen dogs presented for ovariohysterectomy. Methods Dogs were randomly divided into 1 of the 3 antiseptic groups (CG+A, F10, EAW). Skin samples with replicating organism detection and counting plates were taken at 4 different perioperative sites and time intervals (postskin preparation, postskin antisepsis, 2 hours after the second sample, and at the end of surgery) during ovariohysterectomies performed by students. The colony forming unit (CFU) counts from each sample were quantified according to the level of bacterial contamination. Zero CFU was defined as no contamination, 1‐12 CFU was defined as low contamination, and greater than 12 CFU was defined as high contamination. The 3 antiseptics were compared with respect to the level of contamination. Results There was no difference in the level of colonization between the antiseptics at the first sampling time (P = .454). However, the level of contamination for CG+A was lower compared with F10 and EAW at the second, third, and fourth sampling times (P = .001, P = .01, P = .02, respectively). Conclusion CG+A was more effective at achieving a zero CFU count and low levels of contamination compared with F10 and EAW for surgical preparation in dogs undergoing ovariohysterectomy. Clinical significance This study does not provide evidence to support the use of F10 and EAW instead of CG+A for the surgical skin preparation of dogs undergoing ovariohysterectomy.

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supporting

confidence: 75%

Comparative efficacy of three antiseptics as surgical skin preparations in dogs

Boucher

Henton²,

Becker

et al. 2018

Veterinary Surgery

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“…In vitro studies with PVP-I have reported contradictory results [6,7,31,32] . The role of PVP-I in wound healing has also been investigated in animal studies, with varying results [17,33] .…”

Section: Efficacy: In Vivo Studiesmentioning

confidence: 99%

“…With povidone iodine (PVP-I), there have been concerns about allergy, ineffective penetration, and toxic effects on host cells [4][5][6][7] , but how justified are these concerns? There are reports which indicate that these concerns may be based on inappropriately performed in vitro cellular or in vivo animal studies with sometimes limited applicability to the clinical reality [3,8,9] .…”

Section: Introductionmentioning

confidence: 99%

An Asian Perspective on Povidone Iodine in Wound Healing

et al. 2017

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Antiseptics, with a broader spectrum of antimicrobial efficacy, lower risk of antibiotic resistance development, and minimal collateral damage to host tissues, are important alternatives to control the bioburden in wounds. Povidone iodine (PVP-I), in use for several decades, has the broadest spectrum of activity, a persistent antimicrobial effect, an ability to penetrate biofilms, and a lack of acquired or cross-resistance. It demonstrates good skin tolerance and low cytotoxicity. However, some reports on PVP-I have raised concerns over allergy, ineffective penetration, and toxic effects on host cells. The majority of these concerns are based on in vitro or rodent wound studies with diverse study designs and outcomes; these results may not be directly applicable in the clinical reality in humans. In this paper, we discuss the efficacy and safety of PVP-I and outline its place in wound healing in Asia, based on an appraisal of recent literature and clinical practice across the region.

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“…A realização de tratamentos prévios também deve ser levada em consideração, uma vez que podem influenciar negativamente a cicatrização por diminuir a proliferação celular e a resposta imune (MOY, 1993). O peróxido de hidrogênio e as soluções concentradas de iodopovidona possuem efeito citotóxico em fibroblastos e queratinócitos humanos e já se relatou atraso cicatrização em modelos animais (RODEHEAVER et al, 1982). A aplicação tópica de corticosteroides também retarda a cicatrização por meio da diminuição da proliferação de fibroblastos e inibição da síntese proteica (BODNER et al, 1991), mas é benéfica quando há o desenvolvimento de tecido de granulação exuberante.…”

Section: Fatores Que Retardam a Cicatrização Em Equinosunclassified

Enxertos De Pele E Cicatrização Em Equinos

Pedroso¹,

Mendes²,

Coelho³

et al. 2017

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RESUMOAs feridas de pele são muito comuns na clínica de equinos. Os ferimentos localizados em regiões distais dos membros dos equinos são considerados particularmente complicados no que se refere à reparação tecidual. O processo de cicatrização ou de reparo é uma tentativa do organismo restaurar a integridade anatômica ou funcional do tecido lesionado e, didaticamente, pode ser dividido em três fases: fase inflamatória, fase fibroblástica e fase de maturação e remodelamento. Existem vários fatores que afetam o processo de cicatrização na espécie equina. Alguns tratamentos, produtos e procedimentos têm demonstrado benefício nesse processo. Os enxertos de pele são uma boa alternativa, especialmente para feridas em membros distais. O seu uso pode melhorar o resultado final da cicatrização, tanto em relação ao tempo, quanto em relação aos resultados cosméticos e funcionais. PALAVRAS-CHAVE: cavalos, feridas, inflamação, lesão, pinch, punch EQUINE SKIN GRAFTS AND WOUND HEALING ABSTRACTSkin wounds are very common in the equine practice. Wounds located in distal limbs are considered particularly complicated in regard to tissue repair. The process of healing or repair is an body attempt to restore the anatomical or functional integrity of the injured tissue and can be divided into three phases: inflammatory phase, fibroblast phase and maturation and remodeling phase. There are several factors that affect the healing process in the equine species. Some treatments, products and procedures have shown benefit in this process. Skin grafts are a good alternative,

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Bactericidal Activity and Toxicity of Iodine-Containing Solutions in Wounds

Cited by 170 publications

References 6 publications

Comparative efficacy of three antiseptics as surgical skin preparations in dogs

Comparative efficacy of three antiseptics as surgical skin preparations in dogs

An Asian Perspective on Povidone Iodine in Wound Healing

Enxertos De Pele E Cicatrização Em Equinos

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