Bactericidal effect of delmopinol on attached and planktonic <i>Streptococcus sanguinis</i> cells

Burgemeister, Stefan; Decker, Eva-Maria; Weiger, Roland; Brecx, M

doi:10.1034/j.1600-0722.2001.00121.x

Cited by 12 publications

(9 citation statements)

References 12 publications

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“…At that stage, bacteria seem to be highly sensitive to an antibacterial environmental milieu. Another recent study reported S. sanguinis cells to be highly sensitive to antimicrobial substances during the initial adhesion on surfaces (13). The contrasting observation that the resistance of adhered bacteria to biocides increased 5.…”

Section: Discussionmentioning

confidence: 97%

Comparison of antiadhesive and antibacterial effects of antiseptics on Streptococcus sanguinis

Decker

Weiger

Wiech

et al. 2003

European J Oral Sciences

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Three antiseptic (chlorhexidine, Olaflur, Octenisept) and one putative antiadhesive (chitosan) agent were investigated for their effect on viable planktonic and attached Streptococcus sanguinis cells. The bacterial pretreatment with each chemotherapeutic was performed in two steps: (i) After the exposure of planktonic streptococci to the antiseptics, the cells were suspended in human sterile saliva and allowed to attach to human enamel for 60 min; (ii) After 60 min in the flow chamber system, initially attached streptococci were treated with these agents. The microbial viability was monitored by the percentage of vital streptococci determined by fluorescence microscopy and cell reproduction. In comparison with the negative control NaCl, the non-bactericidal chitosan derivative showed distinctive antiadhesive properties. For both treatment procedures, the efficacy of the antiseptics in reducing the viability of planktonic and attached streptococci was Octenisept > Olaflur > chlorhexidine > saline > chitosan. Further studies appear warranted to develop new antiplaque/antibiofilm strategies involving highly efficient bactericidals with antiadhesive formulations.

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Section: Discussionmentioning

confidence: 97%

Comparison of antiadhesive and antibacterial effects of antiseptics on Streptococcus sanguinis

Decker

Weiger

Wiech

et al. 2003

European J Oral Sciences

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“…Listerine® has been shown to significantly reduce gingivitis and plaque without extrinsic staining like that reported with chlorhexidine 9. Decapinol® contains delmopinol hydrochloride, which is bactericidal and reduces the adherence of plaque-forming bacteria 8,12,13. Delmopinol has also been shown to dissolve existing plaque 14.…”

Section: Introductionmentioning

confidence: 92%

The effectiveness of a pre-procedural mouthrinse in reducing bacteria on radiographic phosphor plates

et al. 2014

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PurposeThis study assessed the effectiveness of three antimicrobial mouthrinses in reducing microbial growth on photostimulable phosphor (PSP) plates.Materials and MethodsPrior to performing a full-mouth radiographic survey (FMX), subjects were asked to rinse with one of the three test rinses (Listerine®, Decapinol®, or chlorhexidine oral rinse 0.12%) or to refrain from rinsing. Four PSP plates were sampled from each FMX through collection into sterile containers upon exiting the scanner. Flame-sterilized forceps were used to transfer the PSP plates onto blood agar plates (5% sheep blood agar). The blood agar plates were incubated at 37℃ for up to 72 h. An environmental control blood agar plate was incubated with each batch. Additionally, for control, 25 gas-sterilized PSP plates were plated onto blood agar and analyzed.ResultsThe mean number of bacterial colonies per plate was the lowest in the chlorhexidine group, followed by the Decapinol, Listerine, and the no rinse negative control groups. Only the chlorhexidine and Listerine groups were significantly different (p=0.005). No growth was observed for the 25 gas-sterilized control plates or the environmental control blood agar plates.ConclusionThe mean number of bacterial colonies was the lowest in the chlorhexidine group, followed by the Decapinol, Listerine, and the no rinse groups. Nonetheless, a statistically significant difference was found only in the case of Listerine. Additional research is needed to test whether a higher concentration (0.2%) or longer exposure period (two consecutive 30 s rinse periods) would be helpful in reducing PSP plate contamination further with chlorhexidine.

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“…Delmopinol has also been shown to prevent plaque formation and dissolve existing plaque in vitro (Simonsson et al , 1991). Another study, using Streptococcus sanguinis as target micro‐organism, reported that delmopinol did not affect the total number of bacterial cells attached to glass surfaces but had a bactericidal effect against both adherent and planktonic bacteria (Burgemeister et al , 2001). The observation that delmopinol reduces bacterial acid production is also of interest for caries prevention (Simonsson et al , 1991).…”

Section: Anti‐plaque Agentsmentioning

confidence: 99%

Anti‐plaque agents in the prevention of biofilm‐associated oral diseases

2003

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The prevention of dental caries and periodontal diseases is targeted at the control of dental plaque. In this context, chemical agents could represent a valuable complement to mechanical plaque control. The active agents should prevent biofilm formation without affecting the biological equilibrium within the oral cavity. Depending on the goals of the preventive measures, various strategies may be considered. Anti-plaque agents with properties other than bactericidal or bacteriostatic activities may be used in primary prevention. In this approach, a modest antiplaque effect may be sufficient or even desirable, as it would decrease the side effects of the active agent. Antimicrobial agents are best indicated in secondary and tertiary prevention, as the objectives are to restore health and to prevent disease recurrence. The rational is to prevent or delay subgingival recolonization by pathogenic micro-organisms. The development of in vitro oral biofilm models certainly represents a major advance for studying and testing oral anti-plaque agents in recent years. The results of these studies have shown that chlorhexidine, hexetidine, delmopinol, amine fluoride/stannous fluoride, triclosan, phenolic compounds, among others, may inhibit biofilm development and maturation as well as affect bacterial metabolism.

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Bactericidal effect of delmopinol on attached and planktonic Streptococcus sanguinis cells

Cited by 12 publications

References 12 publications

Comparison of antiadhesive and antibacterial effects of antiseptics on Streptococcus sanguinis

Comparison of antiadhesive and antibacterial effects of antiseptics on Streptococcus sanguinis

The effectiveness of a pre-procedural mouthrinse in reducing bacteria on radiographic phosphor plates

Anti‐plaque agents in the prevention of biofilm‐associated oral diseases

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