Bactericidal effect of iron oxide nanoparticles on Staphylococcus aureus

Tran, Nhiem; Mir, Aparna; Mallik, Dhriti; Sinha, Arvind; Nayar, Suprabha; Webster, Thomas J.

doi:10.2147/ijn.s9220

Cited by 128 publications

(20 citation statements)

References 36 publications

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“…Proposed nanostructures possess well-defined physicochemical properties and proven antibacterial activity. According to published literature [35][36][37], the proposed mode of antibacterial action of magnetic nanoparticles involves their contribution in the induction of oxidative stress, via generation of reactive oxygen species (ROS), as well as interference with the bacterial electron transport of the oxidation of NADH. Moreover, they possess the ability to disrupt the membrane of microorganisms via the formation of a pore or by the endocytosis based mechanism shown in Figure 2.…”

Section: Resultsmentioning

confidence: 99%

“…Proposed nanostructures possess well-defined physicochemical properties and proven antibacterial activity. According to published literature [35][36][37], the proposed mode of antibacterial action of magnetic nanoparticles involves their contribution in the induction of oxidative stress, via generation of reactive oxygen species (ROS), as well as Our previous studies [38][39][40][41] have shown that they interact in a synergistic or additive manner, with chemotherapeutic agents used in standard antimicrobial treatment, as well as with a representative of antimicrobial peptides that take part in the immune-defense process and with their synthetic mimetics. Here we describe how the presence of magnetic nanoparticles might lead to improving the antimicrobial properties of artificial saliva substitutes ( Figure 3).…”

Section: Resultsmentioning

confidence: 99%

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Antimicrobial and Physicochemical Properties of Artificial Saliva Formulations Supplemented with Core-Shell Magnetic Nanoparticles

Niemirowicz-Laskowska

Mystkowska

Łysik

et al. 2020

IJMS

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Saliva plays a crucial role in oral cavity. In addition to its buffering and moisturizing properties, saliva fulfills many biofunctional requirements, including antibacterial activity that is essential to assure proper oral microbiota growth. Due to numerous extra- and intra-systemic factors, there are many disorders of its secretion, leading to oral dryness. Saliva substitutes used in such situations must meet many demands. This study was design to evaluate the effect of core-shell magnetic nanoparticles (MNPs) adding (gold-coated and aminosilane-coated nanoparticles NPs) on antimicrobial (microorganism adhesion, biofilm formation), rheological (viscosity, viscoelasticity) and physicochemical (pH, surface tension, conductivity) properties of three commercially available saliva formulations. Upon the addition of NPs (20 µg/mL), antibacterial activity of artificial saliva was found to increase against tested microorganisms by 20% to 50%. NPs, especially gold-coated ones, decrease the adhesion of Gram-positive and fungal cells by 65% and Gram-negative bacteria cells by 45%. Moreover, the addition of NPs strengthened the antimicrobial properties of tested artificial saliva, without influencing their rheological and physicochemical properties, which stay within the range characterizing the natural saliva collected from healthy subjects.

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Section: Resultsmentioning

confidence: 99%

“…Proposed nanostructures possess well-defined physicochemical properties and proven antibacterial activity. According to published literature [35][36][37], the proposed mode of antibacterial action of magnetic nanoparticles involves their contribution in the induction of oxidative stress, via generation of reactive oxygen species (ROS), as well as Our previous studies [38][39][40][41] have shown that they interact in a synergistic or additive manner, with chemotherapeutic agents used in standard antimicrobial treatment, as well as with a representative of antimicrobial peptides that take part in the immune-defense process and with their synthetic mimetics. Here we describe how the presence of magnetic nanoparticles might lead to improving the antimicrobial properties of artificial saliva substitutes ( Figure 3).…”

Section: Resultsmentioning

confidence: 99%

Antimicrobial and Physicochemical Properties of Artificial Saliva Formulations Supplemented with Core-Shell Magnetic Nanoparticles

Niemirowicz-Laskowska

Mystkowska

Łysik

et al. 2020

IJMS

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“…A comparable effect of ferric oxide and chitosan-coated silver nanoparticles against various bacteria, e.g. S. aureus and P. aeruginosa, has been reported [21,22]. S53P4 granules are described as releasing sodium from its surface after contact with body fluids, thereby increasing the pH into the alkaline range.…”

Section: Platinum -S53p4mentioning

confidence: 76%

Imaging studies of bacterial biofilms on cochlear implants—Bioactive glass (BAG) inhibits mature biofilm

et al. 2020

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The capability of Pseudomonas aeruginosa and Staphylococcus aureus to form biofilm on varying CI component materials differs in the presence and absence of bioactive glass (BAG). The application of BAG induces significant changes in biofilm morphology which can be visualized via scanning electron microscopy (SEM). Bacterial biofilm formation on medical devices, such as cochlear implants (CI), can lead to chronic infections. Interestingly, BAG of type S53P4 seems to be a promising tool for use in the reduction of biofilm development. Primarily, four bacterial species known to cause implant-related infections, P.aeruginosa (ATCC9027), S. aureus (ATCC6538), Staphylococcus epidermidis (ATCC12228) and Streptococcus pyogenes (ATCC19615) were analyzed regarding their capacity to form biofilm on CI components manufactured from three kinds of material: silicone, platinum and titanium. Subsequently, P. aeruginosa and S. aureus biofilms were visualized using scanning electron microscopy, comparing BAG-treated biofilm with non-treated biofilm. The four bacterial species presented biofilm-forming capabilities in a species and surface dependent manner. Metal CI components allowed for the greatest proliferation of biofilm. S. aureus and P. aeruginosa showed the highest rate of biofilm formation on polystyrene surfaces. For both species, SEM revealed altered biofilm morphology after treatment of S53P4 BAG. This study indicates that bacterial biofilm formation and structure on CI components is dependent on the surface composition, altering between metal and silicone surfaces. After application of BAG, changes in biofilm morphology on CI components were observed. These data highlight the impact of BAG on bacterial biofilm morphology.

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“…Antimicrobial resistance is an old and huge concern for public health systems, having grown rapidly in recent times, spreading the preoccupation to economics [92,[95][96][97]. The use of gold, silver, aluminum, and iron oxide as antimicrobials was previously proven [29,[98][99][100][101][102].…”

Section: Antimicrobial Activitymentioning

confidence: 99%

“…These radicals may increase the ROS stress inside the microorganism's cells, leading to an inhibition of their growth and multiplication. ROS may damage the DNA in bacteria and also protein production [101,117,118].…”

Section: Antimicrobial Activitymentioning

confidence: 99%

Pharmaceutical Applications of Iron-Oxide Magnetic Nanoparticles

Bruschi

Toledo

2019

Magnetochemistry

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Advances of nanotechnology led to the development of nanoparticulate systems with many advantages due to their unique physicochemical properties. The use of iron-oxide magnetic nanoparticles (IOMNPs) in pharmaceutical areas increased in the last few decades. This article reviews the conceptual information about iron oxides, magnetic nanoparticles, methods of IOMNP synthesis, properties useful for pharmaceutical applications, advantages and disadvantages, strategies for nanoparticle assemblies, and uses in the production of drug delivery, hyperthermia, theranostics, photodynamic therapy, and as an antimicrobial. The encapsulation, coating, or dispersion of IOMNPs with biocompatible material(s) can avoid the aggregation, biodegradation, and alterations from the original state and also enable entrapping the bioactive agent on the particle via adsorption or covalent attachment. IOMNPs show great potential for target drug delivery, improving the therapy as a consequence of a higher drug effect using lower concentrations, thus reducing side effects and toxicity. Different methodologies allow IOMNP synthesis, resulting in different structures, sizes, dispersions, and surface modifications. These advantages support their utilization in pharmaceutical applications, and getting suitable drug release control on the target tissues could be beneficial in several clinical situations, such as infections, inflammations, and cancer. However, more toxicological clinical investigations about IOMNPs are necessary.

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Bactericidal effect of iron oxide nanoparticles on Staphylococcus aureus

Cited by 128 publications

References 36 publications

Antimicrobial and Physicochemical Properties of Artificial Saliva Formulations Supplemented with Core-Shell Magnetic Nanoparticles

Antimicrobial and Physicochemical Properties of Artificial Saliva Formulations Supplemented with Core-Shell Magnetic Nanoparticles

Imaging studies of bacterial biofilms on cochlear implants—Bioactive glass (BAG) inhibits mature biofilm

Pharmaceutical Applications of Iron-Oxide Magnetic Nanoparticles

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