Bactériémie à Leuconostoc mesenteroides

Azendour, H.; Lahlou, J.; Massou, S.; Balkhi, H.; Haimeur, C.

doi:10.1016/j.annfar.2008.03.013

Cited by 2 publications

(1 citation statement)

References 5 publications

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“…To the best of our knowledge, fewer than 10 cases of L. pseudomesenteroides infections have been reported so far ( 11 – 14 ), all of which occurred in adults. Patients who have received vancomycin are particularly vulnerable ( 7 – 9 ).…”

Section: Discussionmentioning

confidence: 99%

Leuconostoc pseudomesenteroides‑associated hemophagocytic syndrome: A case report

et al. 2017

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Hemophagocytic lymphohistiocytosis (HLH) is a rare hyperinflammatory syndrome characterized by fever, pancytopenia and splenomegaly. The underlying hemophagocytosis occurs primarily in the bone marrow, liver and lymph nodes. Multiple microbiological agents, including cytomegalovirus, Epstein-Barr virus and Mycobacterium tuberculosis, have been implicated in the pathogenesis of HLH. The present study presents a case of HLH associated with Leuconostoc pseudomesenteroides infection treated successfully with clindamycin. A 33-year-old man presented with recurrent episodes of fever and diarrhea. Upon initial treatment at another hospital (the First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China), blood chemistry analysis demonstrated moderate anemia (hemoglobin 88 g/l; reference range, 120.0–160.0), elevated ferritin (1,068.47 mg/l; reference range, 21.81–274.66), total bilirubin (392.4 mmol/l; reference range, 5.1–28.0), conjugated bilirubin (335.7 mmol/l; reference range, 0–10.0), and γ-glutamyl transpeptidase (150 U/l; reference range, 10–60). The patient was treated with antibiotics for suspected pneumonia and cholecystitis, but new symptoms (including diarrhea and inflammatory colitis) started to emerge. The patient was subsequently treated with ganciclovir (5 mg/kg/day for 1 month), but body temperature increased to 41.0°C. Upon transferring to our hospital, the patient had severe anemia (hemoglobin, 39 g/l; red blood cell, 1.61×1012/l; reference range, 4.0–5.5×1012/l). Jaundice was apparent: Total bilirubin, 299.5 mmol/l; conjugated bilirubin, 215.7 mmol/l. The patient was treated with clindamycin (150 mg, taken orally every 12 h for 1 week) and supportive care that included parenteral nutrition. Symptoms rapidly dissipated after the treatment. Blood chemistry analysis 5 days after the first dose of clindamycin revealed substantial improvement in anemia and jaundice. The patient requested discharge for financial reasons, but continued treatment (details not available) at a local hospital (Pengpai Memorial Hospital, Shanwei, China). Upon a visit to our hospital 8 months later, the patient has no notable complaints, with the exception of moderate anemia. The present case suggests that HLH may be associated with L. pseudomesenteroides infection.

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Section: Discussionmentioning

confidence: 99%

Leuconostoc pseudomesenteroides‑associated hemophagocytic syndrome: A case report

et al. 2017

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Bacteremia by Leuconostoc mesenteroides in an immunocompetent patient with chronic Chagas disease: a case report

et al. 2018

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BackgroundThe Leuconostoc mesenteroides are members of the Streptococcae family and currently has been recognized as potential pathogens. This case describes a bacteremia caused by L. mesenteroides in an immunocompetent patient affected by Chagas disease.Case presentationA 67-year-old female patient with chagasic megaesophagus and megacolon was submitted to a Heller myotomy for achalasia in 2000 and endoscopic dilatation in 2015. Patient was admitted to the Nutrology Ward in May 2016 with protein-calorie malnutrition associated with achalasia and receiving enteral nutrition. In July 2016, the patient underwent a Serra-Doria surgery. In the third postoperative day she presented an important abdominal distension. She was submitted to a new surgical intervention, and then a terminal ileum perforation was detected, leading the surgeon to perform an enterectomy with side-to-side anastomosis. The next day after the surgery (4th postoperative day) the patient presented a decreased level of consciousness (Glasgow coma scale = 8), hypotension and hypoxemia. In two samples of blood cultures there was growth of Leuconostoc mesenteroides. Susceptibility pattern was evaluated by the diffusion disk method. The microorganism was susceptible to penicillin, ampicillin, chloramphenicol, erythromycin, and fluoroquinolones, but resistant to rifampin, tetracycline, vancomycin and teicoplanin.ConclusionWe concluded that infections caused by L. mesenteroides is serious and should be considered not only in settings of immunosuppression and prolonged antimicrobial use, but also in immunocompetent patients undergoing surgeries involving the gastrointestinal tract.

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Bactériémie à Leuconostoc mesenteroides

Cited by 2 publications

References 5 publications

Leuconostoc pseudomesenteroides‑associated hemophagocytic syndrome: A case report

Leuconostoc pseudomesenteroides‑associated hemophagocytic syndrome: A case report

Bacteremia by Leuconostoc mesenteroides in an immunocompetent patient with chronic Chagas disease: a case report

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