Bacteriocinogenic potential of a probiotic strain Bacillus coagulans [BDU3] from Ngari

Abdhul, Kaja; Mohan, Ganesh; Shanmughapriya, Santhanam; Vanithamani, Shanmugam; Murugesan, Kanagavel; Anbarasu, Kumarasamy; Natarajaseenivasan, Kalimuthusamy

doi:10.1016/j.ijbiomac.2015.06.005

Cited by 71 publications

(31 citation statements)

References 39 publications

(37 reference statements)

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“…Bacillus strains are also getting recognition as potential probiotics which could promote human health by direct consumption of high concentrations of viable number of cells ( Abdhul et al, 2015 ; Manhar et al, 2016 ). Several Bacillus probiotic strains have been approved by regulatory agencies of different countries for human use and are popular as general health promoting pharmaceutical formulations in global market ( Table 1 ).…”

Section: Spore-formers In Food Chainmentioning

confidence: 99%

“…Recently, a bacteriocin producing strain of probiotic Bacillus coagulans had been isolated from traditional fermented fish of Manipur, India. The purified bacteriocin of low molecular weight displayed broad spectrum of antimicrobial activity against food borne and related clinically relevant pathogens, besides having lower cytotoxicity ( Abdhul et al, 2015 ). Earlier, Joseph et al (2013) also isolated and characterized bacteriocin producing strain of B. subtilis and displayed high level of antimicrobial activity of partially purified bacteriocin against foot ulcer bacterial pathogens, with highest recorded against Klebsiella spp.…”

Section: Bacillus : Probiotic Attributes In Gutmentioning

confidence: 99%

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Bacillus As Potential Probiotics: Status, Concerns, and Future Perspectives

et al. 2017

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Spore-forming bacilli are being explored for the production and preservation of food for many centuries. The inherent ability of production of large number of secretory proteins, enzymes, antimicrobial compounds, vitamins, and carotenoids specifies the importance of bacilli in food chain. Additionally, Bacillus spp. are gaining interest in human health related functional food research coupled with their enhanced tolerance and survivability under hostile environment of gastrointestinal tract. Besides, bacilli are more stable during processing and storage of food and pharmaceutical preparations, making them more suitable candidate for health promoting formulations. Further, Bacillus strains also possess biotherapeutic potential which is connected with their ability to interact with the internal milieu of the host by producing variety of antimicrobial peptides and small extracellular effector molecules. Nonetheless, with proposed scientific evidences, commercial probiotic supplements, and functional foods comprising of Bacillus spp. had not gained much credential in general population, since the debate over probiotic vs pathogen tag of Bacillus in the research and production terrains is confusing consumers. Hence, it’s important to clearly understand the phenotypic and genotypic characteristics of selective beneficial Bacillus spp. and their substantiation with those having GRAS status, to reach a consensus over the same. This review highlights the probiotic candidature of spore forming Bacillus spp. and presents an overview of the proposed health benefits, including application in food and pharmaceutical industry. Moreover, the growing need to evaluate the safety of individual Bacillus strains as well as species on a case by case basis and necessity of more profound analysis for the selection and identification of Bacillus probiotic candidates are also taken into consideration.

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Section: Spore-formers In Food Chainmentioning

confidence: 99%

Section: Bacillus : Probiotic Attributes In Gutmentioning

confidence: 99%

Bacillus As Potential Probiotics: Status, Concerns, and Future Perspectives

et al. 2017

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“…Infectious diseases along with multidrug resistance are the major public health problem in developing countries with increased mortality and morbidity [4,5]. Apart from the threat of multidrug resistance, several studies have confirmed that the continuous use of antibiotics can damage human commensal microbiota [5,6]. Thus, an alternative and effective research focus is necessary to combat these pathogens with no effect on normal microbiota.…”

Section: Introductionmentioning

confidence: 99%

“…Thus, an alternative and effective research focus is necessary to combat these pathogens with no effect on normal microbiota. In this regard, the use of probiotics and their natural metabolic compounds can be a substitute in various food and pharmaceutical industries [5].…”

Section: Introductionmentioning

confidence: 99%

Probiotics for Prevention and Treatment of Candidiasis and Other Infectious Diseases: Lactobacillus spp. and Other Potential Bacterial Species

Silva¹,

Rossoni²,

CamposJunqueira³

et al. 2016

Probiotics and Prebiotics in Human Nutrition and Health

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The resident microbiota in the human body, such as the oral cavity, gastrointestinal tract and genitourinary tract, is able to provide resistance to disease. However, imbalances in the microbial components can promote the growth of opportunistic microorganisms, such as yeasts of genus Candida. Fungal infections present as a major cause of infectious diseases and the microorganisms of genus Candida are the most frequently isolated pathogenic fungi in human fungal infections. Bacillus spp. and Lactobacillus spp. are bacteria that have probiotic effects used in commercially available products and in studies that aim for the development of probiotics able to inhibit the microbial pathogenicity and restore the balance of resident microbiota. Thus, with increasing fungus resistance to the use of antifungal agents, which are capable of causing serious side effects to the host organism unable to destroy the target microorganism, it becomes important to develop therapeutic and/or prophylactic alternatives that have a different and an effective mechanism of action with capacity to combat fungal infections without harming the patient. Probiotic bacteria provide an alternative strategy for the prevention and treatment of candidiasis and other infectious diseases.

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“…Bacillus strains are known as potential probiotics which could promote animals' health by direct consumption of high concentrations of viable number of cells (Guo et al, 2006;Abdhul et al, 2015). For a strain to be selected as a possible probiotic, it should not form halo of degradation around the developed colony.…”

Section: Hemolysis Productionmentioning

confidence: 99%

Preliminary characterisation of Bacillus subtilis strain use as a dietary probiotic bio-additive in weaning piglet

Dumitru¹,

Sorescu²,

Hăbeanu³

et al. 2018

Food & Feed Res

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The aim of the study was to characterize the Bacillus subtilis ATCC 6051a strain, in order to establish its probiotic utility in piglet nutrition. The strain was assayed morphologically, culturally, biochemically, for hemolytic activity and enzymatically (amylase and protease). The identification and analysis of the biochemical characteristics was performed by catalase assay, API 50 CHB Biomerieux strips, apiweb API 50 CHB V 4.0 soft (B. subtilis very good identification, 99.4% ID) and ABIS online. The hemolytic activity was assayed on blood agar medium. The growth activity of strain was evaluated in two ways: static incubation (30 C, 24 h, 1.36 x 10 8 CFU/ml) and under constant agitation (30 C, 24 h, 150 rpm, (1.6 x 10 9 CFU/ml). The strain is a Gram-positive and rodshaped bacteria, arranged in short chains or in small irregular pairs with ability to produce spores on nutrient medium. The endospores were central, paracentral and subterminal, which did not deform the vegetative cell. The strain growth was aerobic and was nonhemolytic. The enzymatic process was observed by appearance of distinct zones around strain colonies. In conclusion, the results suggested that the strain present probiotic traits and can be further assessed for other probiotic characters (resistance to pH 2.0, resistance to bile acids and salts, antibacterial activity, induction of local immune response etc.).

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Bacteriocinogenic potential of a probiotic strain Bacillus coagulans [BDU3] from Ngari

Cited by 71 publications

References 39 publications

Bacillus As Potential Probiotics: Status, Concerns, and Future Perspectives

Bacillus As Potential Probiotics: Status, Concerns, and Future Perspectives

Probiotics for Prevention and Treatment of Candidiasis and Other Infectious Diseases: Lactobacillus spp. and Other Potential Bacterial Species

Preliminary characterisation of Bacillus subtilis strain use as a dietary probiotic bio-additive in weaning piglet

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