Bacteriocins Active Against Multi-Resistant Gram Negative Bacteria Implicated in Nosocomial Infections

Ghodhbane, Hanen; Elaidi, Sabrine; Sabatier, Jean‐Marc; Achour, Sami; Benhmida, Jeannette; Regaya, Imed

doi:10.2174/1871526514666140522113337

Cited by 40 publications

(25 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Bacteriocins are peptides produced by bacterial species in their ecological niches for self-preservation and competitive advantage. The majority of bacteriocins currently recognised are produced by Gram-positive bacteria with few known producers among Gram-negative bacterial species [6]. These small cationic molecules (30-60 amino acids), due to their amphiphilic helices, differ in their spectrum of activity, mode of action, molecular weight, and biochemical properties.…”

Section: Bacteriocinsmentioning

confidence: 99%

“…The outer membrane of Gram-negative species protects them from bacteriocins produced by Gram-positive species. Under stress conditions, however, such as acidic pH, temperature variations, presence of chelators, absence of metal ions and high saline environments, certain Gram-negative species including E. coli [34] and Salmonella become sensitive to Gram-positive bacteriocins [6].…”

Section: Mode Of Actionmentioning

confidence: 99%

“…As such, several lantibiotic peptides displaying outstanding in vivo activity have been put forward clinically for the treatment of potentially fatal bacterial diseases [36]. Furthermore, the lantibiotic mutacin B-Ny266 displays activity against Gram-negative strains of Neisseria and Helicobacter with purified nisin demonstrating activity against E. coli [6]. Extended-spectrum β-lactamase (ESBLs) producing Gram-negative bacteria are of great concern due to their intrinsic resistance to most β-lactam antibiotics including penicillin's and cephalosporins.…”

Section: Infectious Diseasementioning

confidence: 99%

See 2 more Smart Citations

Bacteriocins, Potent Antimicrobial Peptides and the Fight against Multi Drug Resistant Species: Resistance Is Futile?

Slattery²,

2020

View full text Add to dashboard Cite

Despite highly specialized international interventions and policies in place today, the rapid emergence and dissemination of resistant bacterial species continue to occur globally, threatening the longevity of antibiotics in the medical sector. In particular, problematic nosocomial infections caused by multidrug resistant Gram-negative pathogens present as a major burden to both patients and healthcare systems, with annual mortality rates incrementally rising. Bacteriocins, peptidic toxins produced by bacteria, offer promising potential as substitutes or conjugates to current therapeutic compounds. These non-toxic peptides exhibit significant potency against certain bacteria (including multidrug-resistant species), while producer strains remain insusceptible to the bactericidal peptides. The selectivity and safety profile of bacteriocins have been highlighted as superior advantages over traditional antibiotics; however, many aspects regarding their efficacy are still unknown. Although active at low concentrations, bacteriocins typically have low in vivo stability, being susceptible to degradation by proteolytic enzymes. Another major drawback lies in the feasibility of large-scale production, with these key features collectively limiting their current clinical application. Though such limitations require extensive research, the concept of expanding bacteriocins from food preservation to human health opens many fascinating doors, including novel drug delivery systems and anticancer treatment applications.

show abstract

Section: Bacteriocinsmentioning

confidence: 99%

Section: Mode Of Actionmentioning

confidence: 99%

Section: Infectious Diseasementioning

confidence: 99%

See 1 more Smart Citation

Bacteriocins, Potent Antimicrobial Peptides and the Fight against Multi Drug Resistant Species: Resistance Is Futile?

Slattery²,

2020

View full text Add to dashboard Cite

show abstract

“…Published by Rynnye Lyan Resources were bacteriocins in combination with other stressors against Gram-negative food-borne pathogens, bacteriocins in combination with antibiotics against food -borne pathogens, and other strategies such as bacteriocin in combination with phages/endolysins. A bacteriocin active against multi-resistant gram-negative bacteria in nosocomial infections was also reported (Ghodhbane, 2015).…”

Section: Antibiotic Resistancementioning

confidence: 98%

Identification and characterization of lactic acid bacteria isolated from some medicinal and/or edible Philippine plants

Saguibo¹,

Mercado²,

Maldia³

et al. 2019

Food Res.

View full text Add to dashboard Cite

Probiotics research on lactic acid bacteria (LAB) continues to be paramount in the development of nutraceutical or functional foods. In this study, 47 selected Philippine plants having nutritional (edible such as vegetables) and/or medicinal values (therapeutic), were collected, from which selected fruit and leaves were subjected to LAB enumeration. Among these, 46.7% plant leaves reported to have strong antimicrobial property resulted in non-isolation of LAB while edible plant leaves with less or no antimicrobial properties generally gave numerous LAB isolates. Isolates coming from ripened guava (Psidium guajava L.), lobo-lobohan or cape gooseberry (Physalis peruviana L.) fruit, parsley (Petroselinum crispum), pandan (Pandanus amaryllifolius), spinach (Spinacea oleracea), leek (Allium ampeloprasum var. porrum) and niyog-niyogan (Quisqualis indica L.) leaves were identified through partial 16S rRNA analysis and tested for probiotic properties. Overall, Streptococcus luteciae Lb17 from ripe gooseberry fruit exhibited the highest antimicrobial activities against Staphylococcus aureus BIOTECH 1526, Escherichia coli O157: H7 BIOTECH 10311 and Bacillus cereus BIOTECH 1509. On the other hand, Enterococcus hirae (H and S63) from stevia were susceptible to streptomycin at minimum inhibitory concentration or MIC of 128 ug/mL). Lactobacillus plantarum F39 and all the other strains tested, meanwhile, was susceptible to ampicillin at MIC of 2 ug/mL and 0.125 ug/mL. Results were lower or equal to the established cut off value indicating the absence of antibiotic resistance genes among the identified strains, except for Pediococcus (Par5 and NN39) which showed resistance against streptomycin. Further investigation is needed to rule out the possibility of transfer of antibiotic resistance to pathogens present in the gut. All isolates tested were able to survive at artificial gastric juice (pH 2), revived at the simulated intestinal fluid (pH 8), and exhibited minimal titratable acidity and diacetyl production. For genetic screening of plantaricin genes, F39 possesses both plantaricin EF and plantaricin J, while Lactobacillus fermentum F36 has plantaricin EF. Both isolates were subjected to DNA fingerprinting. Such findings on the local isolates' probiotic properties suggest the possibility of incorporating them into different plant-based probiotic foods.

show abstract

“…Infection can be either mono-or polymicrobial, with a wide variety of potential pathogens [1]. Multiresistant gram-negative bacteria are the prime mover of nosocomial infections [2]. Healthcare-associated infections (HCAI) represent up to 50 % of all infections among patients admitted from the community [3].…”

Section: Introductionmentioning

confidence: 99%

The Common Bacterial Infections in Patients with Leg or Hand Infections

2018

AEBMS-2017, ICCET-2017, BBMPS-17, UPACEE-17, LHESS-17, TBFIS-2017, IC4E-2017, AMLIS-2017 &Amp; BEFM-2017

View full text Add to dashboard Cite

The aim of this study was to determine the common bacteria involved in leg or hand infections. The documentary data of 91 patients with leg or hand inflammation were collected and statistically studied using descriptive statistics. Our findings indicated that the ratio of female to male was 0.47 (Figure I). Age mean was 41.75 and 79.34 years old in females and males, respectively (Figure II). Staphylococcus aureus and Enterobacter infection were higher than other types of bacterial infections.

show abstract

Bacteriocins Active Against Multi-Resistant Gram Negative Bacteria Implicated in Nosocomial Infections

Cited by 40 publications

References 0 publications

Bacteriocins, Potent Antimicrobial Peptides and the Fight against Multi Drug Resistant Species: Resistance Is Futile?

Bacteriocins, Potent Antimicrobial Peptides and the Fight against Multi Drug Resistant Species: Resistance Is Futile?

Identification and characterization of lactic acid bacteria isolated from some medicinal and/or edible Philippine plants

The Common Bacterial Infections in Patients with Leg or Hand Infections

Contact Info

Product

Resources

About