Bacterioferritin nanocage: Structure, biological function, catalytic mechanism, self-assembly and potential applications

Guo, Minliang; Gao, Miaomiao; Liu, Jinjing; Xu, Nan; Wang, Hao

doi:10.1016/j.biotechadv.2022.108057

Cited by 9 publications

(4 citation statements)

References 145 publications

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“…The chemical and physical properties of nanocages can be tailored by adjusting pore size, shell thickness, and overall shape (Skrabalak et al, 2007). One commonly employed technique for nanocage synthesis involves galvanic replacement, which relies on oxidation and dissolution of atoms from one material and a reduction and deposition of a second material from a salt precursor onto the first (Grote et al, 2023; Guo et al, 2022; Song et al, 2022). Here, the template material is often nanosilver or another metal with a low reduction potential.…”

Section: Shape‐controlled Synthesis and Properties Of Metallic Nanopa...mentioning

confidence: 99%

A review of recent advances in the use of complex metal nanostructures for biomedical applications from diagnosis to treatment

Hajfathalian,

Mossburg,

Radaic

et al. 2024

WIREs Nanomed Nanobiotechnol

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Complex metal nanostructures represent an exceptional category of materials characterized by distinct morphologies and physicochemical properties. Nanostructures with shape anisotropies, such as nanorods, nanostars, nanocages, and nanoprisms, are particularly appealing due to their tunable surface plasmon resonances, controllable surface chemistries, and effective targeting capabilities. These complex nanostructures can absorb light in the near‐infrared, enabling noteworthy applications in nanomedicine, molecular imaging, and biology. The engineering of targeting abilities through surface modifications involving ligands, antibodies, peptides, and other agents potentiates their effects. Recent years have witnessed the development of innovative structures with diverse compositions, expanding their applications in biomedicine. These applications encompass targeted imaging, surface‐enhanced Raman spectroscopy, near‐infrared II imaging, catalytic therapy, photothermal therapy, and cancer treatment. This review seeks to provide the nanomedicine community with a thorough and informative overview of the evolving landscape of complex metal nanoparticle research, with a specific emphasis on their roles in imaging, cancer therapy, infectious diseases, and biofilm treatment.This article is categorized under: Diagnostic Tools > In Vivo Nanodiagnostics and Imaging Therapeutic Approaches and Drug Discovery > Nanomedicine for Infectious Disease Diagnostic Tools > Diagnostic Nanodevices

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Section: Shape‐controlled Synthesis and Properties Of Metallic Nanopa...mentioning

confidence: 99%

A review of recent advances in the use of complex metal nanostructures for biomedical applications from diagnosis to treatment

Hajfathalian,

Mossburg,

Radaic

et al. 2024

WIREs Nanomed Nanobiotechnol

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“…Typically, 24 monomers form a cage-like structure in which iron is stored [67] (Figure 2). Bacterial genomes can encode different classes of ferritins: Ftns, similar to animal ferritins; Bfrs, heme-containing bacterioferritins (Bfrs); and mini-ferritins (Dpn), with only 12 monomers instead of the typical 24 [68,69]. The genome of A. vinelandii encodes one ferritin, two bacterioferritins, and one mini-ferritin.…”

Section: Iron Trafficking In the Cytosolmentioning

confidence: 99%

Iron Homeostasis in Azotobacter vinelandii

Rosa-Núñez,

Echavarri-Erasun,

Armas

et al. 2023

Biology

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Iron is an essential nutrient for all life forms. Specialized mechanisms exist in bacteria to ensure iron uptake and its delivery to key enzymes within the cell, while preventing toxicity. Iron uptake and exchange networks must adapt to the different environmental conditions, particularly those that require the biosynthesis of multiple iron proteins, such as nitrogen fixation. In this review, we outline the mechanisms that the model diazotrophic bacterium Azotobacter vinelandii uses to ensure iron nutrition and how it adapts Fe metabolism to diazotrophic growth.

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“…Helicobacter pylori ferritin, referred to as ferritin hereafter, is a non-heme binding ferritin that controls iron storage within the bacterium and shares structural similarities with other bacterioferritins [41][42][43][44][45][46]. Ferritin forms a 24-subunit nanoparticle consisting of a 5-helix subunit where the first 4 helices form a bundle, and the 5th shorter helix is internal to the nanoparticle, forming stabilizing interactions within the nanoparticle [41][42][43][44][45]. Ferritin has 2-, 3-, and 4-fold symmetry resulting in 24-unit nanoparticles [41][42][43][44][45].…”

Section: Introductionmentioning

confidence: 99%

“…Ferritin forms a 24-subunit nanoparticle consisting of a 5-helix subunit where the first 4 helices form a bundle, and the 5th shorter helix is internal to the nanoparticle, forming stabilizing interactions within the nanoparticle [41][42][43][44][45]. Ferritin has 2-, 3-, and 4-fold symmetry resulting in 24-unit nanoparticles [41][42][43][44][45]. This symmetry is particularly useful for attaching antigens that require dimeric or trimeric interactions for the correct presentation of the antigen.…”

Section: Introductionmentioning

confidence: 99%

A Self-Assembling Pfs230D1-Ferritin Nanoparticle Vaccine Has Potent and Durable Malaria Transmission-Reducing Activity

Salinas,

Ma,

McAleese

et al. 2024

Vaccines

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Malaria is caused by eukaryotic protozoan parasites of the genus Plasmodium. There are 249 million new cases and 608,000 deaths annually, and new interventions are desperately needed. Malaria vaccines can be divided into three categories: liver stage, blood stage, or transmission-blocking vaccines. Transmission-blocking vaccines prevent the transmission of disease by the mosquito vector from one human to another. Pfs230 is one of the leading transmission-blocking vaccine antigens for malaria. Here, we describe the development of a 24-copy self-assembling nanoparticle vaccine comprising domain 1 of Pfs230 genetically fused to H. pylori ferritin. The single-component Pfs230D1-ferritin construct forms a stable and homogenous 24-copy nanoparticle with good production yields. The nanoparticle is highly immunogenic, as two low-dose vaccinations of New Zealand White rabbits elicited a potent and durable antibody response with high transmission-reducing activity when formulated in two distinct adjuvants suitable for translation to human use. This single-component 24-copy Pfs230D1-ferritin nanoparticle vaccine has the potential to improve production pipelines and the cost of manufacturing a potent and durable transmission-blocking vaccine for malaria control.

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Bacterioferritin nanocage: Structure, biological function, catalytic mechanism, self-assembly and potential applications

Cited by 9 publications

References 145 publications

A review of recent advances in the use of complex metal nanostructures for biomedical applications from diagnosis to treatment

A review of recent advances in the use of complex metal nanostructures for biomedical applications from diagnosis to treatment

Iron Homeostasis in Azotobacter vinelandii

A Self-Assembling Pfs230D1-Ferritin Nanoparticle Vaccine Has Potent and Durable Malaria Transmission-Reducing Activity

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