Bacteriologic findings in Patients with Chronic Sinusitis

Abstract

We studied the bacteriology ofmaxillary sinus aspirates obtain ed from patients diagnosed with chronic sinusitis. We recovered 659 strains from 510 aspirates; of these, 572 (86.8 %) were aerobes and 87 (13.2 %) were anaerobes. Aerobes only were recovered from 310 of the 510 specimens (60.8%) and anaerobes only from 31 (6.1 %). Among the 572 aerobic bacteria, the most prevalent organisms were Streptococcus viridans (158 strains [27.6%]), Streptococcus pneumoniae (67 [11 .7 %}), Corynebacterium species (66 [11 .5 %]), Staphylococcus aureus (54 [9.4%]), Moraxella catarrhalis (38 [6.6%]), Hemophilus parainfluenzae (33 [5.8%]), and group C beta-hemolytic streptococci (26 [4.5%]). Amon g the 87 recovered anaerobes were species ofPep tostreptococcus (32 strains [36.8 %]), Prevotella (22 [25.3 %]), Actinomyces (13 [14.9 %]), Propionibacterium (11 [12.6%]), Fusobacterium (8 [9 .2 %]), and Veillonella (l [1.1%]). Beta-lactamase p roduction was detected in 115 ofthe 572 aerobic strains (20.1 %) and in 10 of the 87 anaerobic strains (11.5 %). Wefound that the prevalence and type of organisms we identified in chronic sinusitis did not differ substantiallyfrom those reported in pr evious studies. Our study is one ofthe more extensive reports on the type and prevalence ofpathogens in chronic sinusitis that has been publ ished to date.

Histological and Immunological Observations of Bacterial and Allergic Chronic Rhinosinusitis in the Mouse

“…1 However, in our present study, we used S. pneumoniae instead of Bacteroides fragilis, because S. pneumoniae is the predominant organism in the cultures of maxillary sinus aspirates obtained from patients diagnosed with CRS. 7 Although Jacob et al observed obvious histological changes in his model, the 4-week study duration is not in accordance with the current definition of human CRS. 1 Our study showed a 12-week intervention, which fit the definition of human CRS, and provoked more persistent and severe pathological changes of CRS than a 4-week intervention.…”

The microbiome and chronic rhinosinusitis

“…coli , Peptostreptococcus sp, Klebsiella sp, and Fusobacterium are also seen in lower abundance. 39 , 40 , 41 , 42 , 43 However, with the exception of S . aureus , the association between any single species and CRS is tenuous.…”

Chronic Sinusitis in Children

“…[17][18][19][20] Coagulase-negative staphylococci are frequently isolated, but it is not clear whether these represent true causative bacteria. …”