Bacteriological and serological study of chronic prostatitis patients.

Abstract

Chronic prostatitis is not uncommon in men over 50 years, though it can occur at any age. The organisms most commonly isolated from the prostatic secretion are staphylococci, streptococci, coliform bacilli, and diphtheroids. Nickel (1930) (1938) remarked that the incrimination of gonococci as a common cause of prostatitis was questionable; in his opinion non-specific prostatitis was generally present at the time of contraction of gonorrhoeal urethritis, and this antecedent infection persisted after the gonococci had disappeared. Kretschmer, Berkey, Heckel, and Ockuly (1937) found only 24 cases of gonorrhoeal infection in 1,000 patients with chronic prostatitis. According to Pelouze (1939) 95 per cent. of cases of chronic prostatitis were secondary to infections elsewhere in the body, the most common primary foci being the teeth and tonsils; he also stated that 35 per cent. of all men over 50 years have chronic prostatitis and that in 95 per cent. dental infection was the primary focus of the prostatic infection. The infection may be related to prolonged congestion which may cause a fertile field for bacterial invasion.Chronic urethral infections may easily pass directly into the prostatic ducts. Invasion of the * Received for publication December 15, 1964. prostate may also occur from lymphatics, from adjacent organs or from infections higher in the urinary tract with infected urine.Since urinary tract infections and complications are common in Egypt through bilharziasis, one would expect that the most common route of invasion of the prostate would be the urinary tract. Knowledge of the route of invasion is important in treating inflammation and preventing its recurrence.The aim of the present work was to study patients suffering from chronic bacterial prostatitis to discover the incidence of bacteria in bacterial prostatitis, and to evaluate the urinary tract as the possible route of invasion of the prostate.Because of the high incidence of staphylococcal infections without associated urinary tract infection, a group of these patients were subjected to: (a) A bacteriological study of the staphylococci causing prostatitis and their sensitivity to penicillin. (b) A serological study of the sera and prostatic fluids for the presence of antibodies to the strain of staphylococcus isolated. (c) A bacteriological and serological follow-up of these patients was attempted.Material and Methods 150 patients with chronic bacterial prostatitis attending the out-patient clinic ofDemerdash Hospital were studied and those were included whose prostatic secretions showed signs of inflammation with pus counts above ten per high-power field, the bacteria giving cultures of more than twenty colonies per Petri dish.A control group of twenty normal men between 20 and 40 years of age were examined in the same way as the patients.From all patients and normal controls the following specimens were collected aseptically: (1) Urine before and after prostatic massage.

Use of a solid-phase radioimmunoassay and formalin-fixed whole bacterial antigen in the detection of antigen-specific immunoglobulin in prostatic fluid.

“…In previous studies, investigators have looked to immunoglobulins as markers of prostatic infection. Some have described serum agglutination titers (4,5,13), and others have only examined total immunoglobulin in prostatic secretion (2,3,14). The problems with some of these studies were reviewed by Meares (15).…”

Inhibition of Folate Metabolism in Chemotherapy

“…MEARES (1977) has reported bacterial agglutination titers in the serum of patients with chronic bacterial prostatitis and compared these titers with both normal controls and patients whose urethra was colonized with Enterobacteriaceae; he later reported longitudinal studies on serum antibody titers in the treatment of chronic bacterial prostatitis with trimethoprim/sulfamethoxazole (MEARES 1978). Serum and prostatic fluid agglutinins have also been reported in 60 patients against strains of staphylococci considered to be prostatic in origin (MAGED and KHAFAGA 1965); bacteriologic documentation that these staphylococci were prostatic rather than urethral in origin did not accompany this report. Serum and prostatic fluid agglutinins have also been reported in 60 patients against strains of staphylococci considered to be prostatic in origin (MAGED and KHAFAGA 1965); bacteriologic documentation that these staphylococci were prostatic rather than urethral in origin did not accompany this report.…”

Η Αξια Του Προσδιορισμου Των Ισοενζυμων Της LDH Του Προστατικου Υγρου Στη Διαγνωση Της Χρονιας Προστατιτιδας

“…0 κύριος λόγος είναι ότι, ενώ οι περισσότεροι συγγραφείς επιμένουν ότι μι κροβιακή φλεγμονή του προστάτη μπορούν να προκαλέσουν μόνο αρνητικά κα τά gram μικρόβια και από τα θετικά κατά gram μόνο ο εντερόκοκκος (Τ. Stamey 1974, Meares 1980, Pfau 1983, άλλοι δέχονται σαν παθογόνα αίτια και τα άλλα θετικά κατά gram μικρόβια (Drach 1975, Maged and Khafaga 1965, Giamarellou και συν. 1982.…”