Bacteriological, Chemical, and Nutritional Studies of Dental Caries by the Michigan Research Group

Bunting, Russell W.

doi:10.1177/00220345340140020801

Cited by 20 publications

(3 citation statements)

References 6 publications

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“…Groups 2 and 3, then, ought t o give an arrested or at any rate retarded caries, while the control group should give a "normallyy' progressive caries. Under the present conditions the author has not been able to have such a test established, but evidence for group 2 can be extracted from BUN-TING,~ experiments (2). Herekit is reported that in American internates a restriction of sugar in the diet has lead to a marked decrease in caries frequency.…”

Section: )mentioning

confidence: 79%

The Combination Bread—Sugar as a Cause for Dental Caries

Schulerud

1945

Acta Odontologica Scandinavica

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Section: )mentioning

confidence: 79%

The Combination Bread—Sugar as a Cause for Dental Caries

Schulerud

1945

Acta Odontologica Scandinavica

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“…The oral health domain has substantially benefited from the last century of advances in genetics and genomics. As early as the 1920s, authors started to observe the heritability of dental caries [ 10 – 13 ]. In 1956, an oral pathologist, Carl J. Witkop jnr, established the Human Genetics Section of the National Institute of Dental Research (NIDR) in the United States.…”

Section: The Evolution Of Dental Sciencementioning

confidence: 99%

Bridging the gap between omics research and dental practice

Kabbashi,

Roomaney,

Chetty

2024

BDJ Open

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Aim The burgeoning field of omics research has witnessed exponential growth in both medicine and dentistry. However, despite more than a decade of advancements, clinical dentistry, particularly in Low- and Middle-Income Countries (LMICs), has seen limited progress in integrating omics-based approaches into routine practice. This review aims to provide a comprehensive overview of the integration of omics approaches in dentistry, focusing on the challenges and opportunities for translating research findings into clinical practice. Methods we conducted a literature review using key databases to provide a brief overview of the history of genomics in dentistry. Additionally, we summarised recent breakthroughs in omics relevant to oral health practitioners, emphasising the inadequate translation of omics research into clinical practice. Results Despite significant growth in omics research in both medicine and dentistry, its translation into routine clinical practice in dentistry remains limited. We summarise recent breakthroughs in omics and highlight the gap between research advancements and clinical implementation. Discussion and conclusion The integration of omics approaches holds promise for enhancing diagnostics, personalised treatment strategies, and preventive measures in dental practice, ushering in a new era of precision oral healthcare. However, several challenges, including infrastructure limitations, cost-effectiveness, and education gaps, hinder the widespread adoption of omics-based approaches in clinical dentistry. A strong commitment to transforming dentistry is required to embrace this transition. This shift has the potential to revolutionise oral healthcare by advancing precision diagnostics and treatment strategies tailored to individual patient needs.

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“…2). Observations regarding a hereditary component of dental caries were reported as early as in the 1920s (Kappes 1928; Bunting 1934; Klein and Palmer 1940; Hunt et al 1944). In a key paper while at the National Institute of Dental Research, Carl Witkop, who later edited the book Genetics and Dental Health , presented an overview of dental hereditary diseases, including dentinogenesis imperfecta, dentin dysplasia, enamel hypoplasia, tooth agenesis, Ehlers-Danlos, ankyloglossia, and dental caries (Witkop 1958).…”

Section: Advances In Genomics and Dental Medicinementioning

confidence: 99%

The Era of the Genome and Dental Medicine

Divaris

2019

J Dent Res

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Understanding the “code of life” and mapping the human genome have been monumental and era-defining scientific landmarks—analogous to setting foot on the moon. The last century has been characterized by exponential advances in our understanding of the biological and specifically molecular basis of health and disease. The early part of the 20th century was marked by fundamental theoretical and scientific advances in understanding heredity, the identification of the DNA molecule and genes, and the elucidation of the central dogma of biology. The second half was characterized by experimental and increasingly molecular investigations, including clinical and population applications. The completion of the Human Genome Project in 2003 and the continuous technological advances have democratized access to this information and the ability to generate health and disease association data; however, the realization of genomic and precision medicine, to practically improve people’s health, has lagged. The oral health domain has made great strides and substantially benefited from the last century of advances in genetics and genomics. Observations regarding a hereditary component of dental caries were reported as early as the 1920s. Subsequent breakthroughs were made in the discovery of genetic causes of rare diseases, such as ectodermal dysplasias, orofacial clefts, and other craniofacial and dental anomalies. More recently, genome-wide investigations have been conducted and reported for several diseases and traits, including periodontal disease, dental caries, tooth agenesis, cancers of the head and neck, orofacial pain, temporomandibular disorders, and craniofacial morphometrics. Gene therapies and gene editing with CRISPR/Cas represent the latest frontier surpassed in the era of genomic medicine. Amid rapid genomics progress, several challenges and opportunities lie ahead. Importantly, systematic efforts supported by implementation science are needed to realize the full potential of genomics, including the improvement of public and practitioner genomics literacy, the promotion of individual and population oral health, and the reduction of disparities.

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Bacteriological, Chemical, and Nutritional Studies of Dental Caries by the Michigan Research Group

Cited by 20 publications

References 6 publications

The Combination Bread—Sugar as a Cause for Dental Caries

The Combination Bread—Sugar as a Cause for Dental Caries

Bridging the gap between omics research and dental practice

The Era of the Genome and Dental Medicine

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