Bacteriological Differences Between COPD Exacerbation and Community-Acquired Pneumonia

Li, Xuejun; Li, Qi; Si, Liang-Yi; Yuan, Qiao-Ying

doi:10.4187/respcare.00915

Cited by 37 publications

(37 citation statements)

References 23 publications

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“…This isolation rate is in accordance with previous studies reporting an isolation rate of 32 % to 51 % performed in similar settings [16][17][18][19]. Our results demonstrated a predominance of P. aeruginosa, S. pneumonia, H. influenzae, and A. baumanii as the most common sputum isolates in AECOPD patients requiring hospitalization.…”

Section: Discussionsupporting

confidence: 82%

“…isolates in respiratory samples of COPD patients with severe exacerbations. Previous studies have demonstrated a significant variation in the relative incidence of specific pathogens in AECOPD, which may relate to patient inclusion criteria, settings and environmental or epidemiological factors [10,[19][20][21][22]. Nearly 15% of our study group had at least two prior admissions in the previous year before enrollment into this study.…”

Section: Discussionmentioning

confidence: 99%

“…Recently, Dai et al [20] reported that Pseudomonas, followed by A. baumanii, Klebsiella, E. coli and S. pneumonia in bacteriologic analyses of sputum in patients with hospitalized AECOPD patients [20]. Moreover, Li et al [19] reported Pseudomonas as the most common pathogen in patients with COPD exacerbation. Besides Soler et al [21] reported a high rate of Gram-negative bacteria and Pseudomonas/Stenotrophmonas spp.…”

Section: Discussionmentioning

confidence: 99%

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Bacterial etiology in acute hospitalized chronic obstructive pulmonary disease exacerbations

Dilektaşlı¹,

Cetinoglu²,

Öztürk³

et al. 2016

Eur Res J

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Objectives. The most common cause of acute COPD exacerbation (AECOPD) is the respiratory tract infections. We sought to determine the bacteriological etiology of hospitalized acute exacerbations of COPD requiring hospitalization in consecutive two years. Methods. We aimed to determine the bacteriological etiology underlying in patients whom admitted to Uludag University Faculty of Medicine, Department of Pulmonary Medicine and hospitalized with AECOPD in the last two years. Medical records of the study participants were screened retrospectively and sociodemographic characteristics, routine laboratory tests and sputum culture results were analyzed. Results. A total of 242 patients hospitalized for AECOPD were enrolled. Of these 86.4% (n=209) were male. The mean age of the group was 66.6±11 years old. Sputum cultures were available in the 45 % (n=109) of the study group. The most frequent bacteria isolated from the sputum cultures of the study group were Pseudomonas aeruginosa, Streptococcus pneumonia, Haemophilus influenzae and Acinetobacter baumanii. Length of stay was longer in patients with the A. baumanii isolate than the rest of the group (p=0.024). Length of stay in hospital was independently associated with in-hospital mortality (OR: 1.37, 95% CI: 1.05-1.78). Isolation of A. baumanii and/or Staphylococcus aureus in sputum culture were identified as independent risk factors for prolonged length of stay in-hospital (b=0.26, p=0.008; b=15.40, p=0.003). Conclusions. Our study shows that P. aeruginosa, S. pneumonia, H. influenzae are common sputum isolates in AECOPD patients requiring hospitalization. Isolation of A. baumanii and/or S. aureus in sputum culture is associated with prolonged length of stay in hospital, which is an independent risk factor for in-hospital mortality.Eur Res J 2016;2(2):99-106

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Section: Discussionsupporting

confidence: 82%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Bacterial etiology in acute hospitalized chronic obstructive pulmonary disease exacerbations

Dilektaşlı¹,

Cetinoglu²,

Öztürk³

et al. 2016

Eur Res J

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“…Although P. aeruginosa rarely causes community-acquired pneumonia, there have been high morbidity and mortality rates amongst high-risk patients, including those who are w62 years old or immunocompromised with pre-existing conditions, such as human immunodeficiency virus infection, diabetes mellitus, renal failure, burns, chronic obstructive pulmonary disease, smoker or congestive heart failure (Jorgensen & Ferraro, 2009;Li et al, 2011;Shah et al, 2010). In addition, P. aeruginosa has increased resistance to many antibiotics due to several adaptations, which include membrane impermeability, efflux pumps, biofilm formation and enzyme expression (Henwood et al, 2001;Landman et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

Multiple antibiotic resistance index, fitness and virulence potential in respiratory Pseudomonas aeruginosa from Jamaica

Davis

Brown

2016

Journal of Medical Microbiology

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Respiratory infections are common causes of morbidity and mortality worldwide. We sought to assess the multiple antibiotic resistance (MAR) index, fitness and virulence potential in Pseudomonas aeruginosa from patients with lower respiratory tract infections. Isolates were assessed for antimicrobial susceptibility, in vitro competitive fitness, and pigment, elastase and rhamnolipid production. Oxidative stress tolerance was determined on both planktonic and biofilm cells, and virulence potential was tested in a plant model. Mean MAR index for isolates was 0.34 (range 0.17-0.50). Whilst isolates exhibited good biofilm formation in the presence of ciprofloxacin, there was no significant difference in biofilm production over the concentration range assessed. Several drug-resistant strains were out-competed by a susceptible strain even in the presence of antibiotic. H 2 O 2 exerted a greater oxidative stress than tert-butylhydroperoxide and, as expected, biofilms were more resistant than planktonic cells. Whilst most (81 %) isolates were pigmented there was no significant difference between pigmented and non-pigmented isolates when elastolytic activity was compared (P.0.05). More than half of the isolates produced the quorum sensing mediator rhamnolipid and infection of the plant model by bacteria occurred whether elastase or rhamnolipid was present or absent. These data suggest that non-pigmented strains of P. aeruginosa might pose an equally significant microbiological threat as pigmented strains even though pigment production appeared to be strongly associated with elastase expression. Whilst dual expression of elastase and rhamnolipid by these bacteria would cause severe tissue damage (as seen in the plant model), non-production of either does not prevent bacteria from causing serious infection.

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“…[14][15][16] Although the effect of colonized bacteria on acute exacerbations is not yet clear, more recently, in the relationship between acute exacerbation and increased bacterial burden, the proliferation of new strains has been suggested. [17][18] From studies evaluating the parameters associated with bacterial colonization, a significant relationship was found between the frequency of exacerbations and increased colonization. 14,19 There are studies showing correlation between the decrease in FEV1 and the colonization.…”

Section: Etıology Of Exacerbatıonsmentioning

confidence: 99%

Acute Exacerbation of Chronic Obstructive Lung Disease: Etiology and Treatment.

Aydemir¹

2014

Sakarya Med J

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Kronik obstrüktif Akciğer Hastalığı (KOAH), tüm dünyada ve ülkemizde sıklığı giderek artan bir küresel sağlık sorunudur. Acil servis başvuruları ve hastane yatışlarının önemli bir nedeni olan akut alevlenmeler, bu sorunun en büyük bileşenidir. Akut alevlenmeler, ağır solunum yetmezliğine gidiş sürecini hızlandırır, yüksek oranda mortalite ve morbidite nedenidir ve ülkelerin sağlık harcamalarında ciddi bir yük oluşturur. Alevlenmelerin etyolojisi ve tedavisi özellikle acil servisaile hekimleri, evde sağlık hizmeti sunucuları ve göğüs hastalıkları ile ilgilenen hekimlerce iyi bilinmelidir. Özet AbstractDerleme / Review

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Bacteriological Differences Between COPD Exacerbation and Community-Acquired Pneumonia

Cited by 37 publications

References 23 publications

Bacterial etiology in acute hospitalized chronic obstructive pulmonary disease exacerbations

Bacterial etiology in acute hospitalized chronic obstructive pulmonary disease exacerbations

Multiple antibiotic resistance index, fitness and virulence potential in respiratory Pseudomonas aeruginosa from Jamaica

Acute Exacerbation of Chronic Obstructive Lung Disease: Etiology and Treatment.

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