Bacteriological Profile and Drug Resistance Patterns of Blood Culture Isolates in a Tertiary Care Nephrourology Teaching Institute

Abstract

Blood stream infections can lead to life threatening sepsis and require rapid antimicrobial treatment. The organisms implicated in these infections vary with the geographical alteration. Infections caused by MDR organisms are more likely to increase the risk of death in these patients. The present study was aimed to study the profile of organisms causing bacteremia and understand antibiotic resistance patterns in our hospital. 1440 blood samples collected over a year from clinically suspected cases of bacteremia were studied. The isolates were identified by standard biochemical tests and antimicrobial resistance patterns were determined by CLSI guidelines. Positive blood cultures were obtained in 9.2% of cases of which Gram-positive bacteria accounted for 58.3% of cases with staph aureus predominance; gram negative bacteria accounted for 40.2% with enterobactereciea predominence; and 1.5% were fungal isolates. The most sensitive drugs for Gram-positive isolates were vancomycin, teicoplanin, daptomycin, linezolid, and tigecycline and for Gram-negative were carbapenems, colistin, aminoglycosides, and tigecycline. The prevalence of MRSA and vancomycin resistance was 70.6% and 21.6%, respectively. ESBL prevalence was 39.6%. Overall low positive rates of blood culture were observed.

Bacteremia Prediction by Inflammatory Factors and Recent Trend in Drug Resistance of Bacteria Isolated from Blood Stream Infection

“…Similar rate was reported in a study conducted by Falagas et al (2008). Similar frequencies of Pseudomonas, Salmonella, Acinetobacter, Candida, Moraxella and Streptococcus species were obtained as reported by Gohel and his colleagues (Gohel et al, 2014).…”

“…In our study, an average of 10 mL sample volume was used. 14.75% positive and 85.25% negative blood culture rates correlated with a study conducted by Gohel et al (2014). The improper sample transport conditions observed in distant sample collection centers, can have impact by increasing false negative results.…”

Bacteriological Profile and Antimicrobial Resistance of Blood Culture Isolates from a 350 bedded Hospital Lucknow, India

“…was the predominant isolate 20.8% cases in this present paper. The isolation of Enterococcus is the consist with the study with the contradictory result kalpesh et al, 3.5% (2014) …”

Escherichia coli Free Radical-Based Killing Mechanism Driven by a Unique Combination of Iron Restriction and Certain Antibiotics

“…Seven of the antibiotics were also tested against S. aureus, another serious multidrug-resistant species (see Table S1). ExPEC and S. aureus are the Gram-negative and Gram-positive species, respectively, most frequently isolated from the blood of infected patients (32). These bacteria were also tested for sensitivity to the FDA-approved iron chelators DFP and DFX and an iron chelator commonly used in the research laboratory, DIP.…”