Bacteriological profile and their antimicrobial susceptibility pattern in central venous catheter tip culture

Background: ICU infections are major health care problems affecting millions globally each year. ICU mortality of infectious patients is increasing and as high as 14.31% to 45.4%. The objective of this study was to determine microbiological culture profile, their antimicrobial susceptibility and treatment outcome of patients admitted to intensive care units.Methods and materials: An institutional based cross sectional study was conducted in all patients with microbiological culture and susceptibility results after admission to intensive care units from January 2019 to December 2019. A modified, pretested questionnaire was used to collect data and analyzed using SPSS version 25. Correlation and regression analysis was done for association. P value of <0.05 with CI of 95% was taken as clinically significant.Results: A total of 106 patients with 173 culture results were analyzed. Majority 68(64.2%) were males and the mean age of the patients were 35.08 ± 1.6 years. The most common source of infection was the pulmonary system 84(54.5%) followed by urinary tract infection 26(16.9%). Forty-four (25.43%) of cultures had growth. Gram negative microorganisms were identified in 35(68.63%) of isolates and Acinetobacter species accounts for 10(28.57%) followed by Klebsiella pneumonia and E. coli 7(13.725%) each. Generally, higher resistance was observed with cephalosporins and penicillins, whereas sensitivity to carbapenems, PIP/TAZ, and amikacin was satisfactory. The mortality associated with intensive care infections was found to be 32.1%.Conclusion: This study revealed that the mortality rate associated with ICU infection was 32.1%. Early identification, targeted provision of antimicrobials based on microbiological culture and susceptibility result has to be implemented to have better outcome. Designs of future multicenter and large studies are crucial to improve outcome of critically ill patients.

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“…Gram negatives were the most commonly identi ed microorganisms similar with other studies, but the isolated species were different (32,33,34).…”

supporting

confidence: 80%

“…Of the 106 patients studied 173 cultures sent were analyzed, and only 44(25.43%) of cultures had growth of microorganisms with 51 isolates, which was similar with a study in eastern Ethiopia hospitals with isolation rate of 27.9%, but higher than that of a study done in TASH 16.5% and lower than a study done in Nepal 39.6% (32,33,34).…”

supporting

confidence: 79%

Microbiological Profile, Antimicrobial Susceptibility, and Outcome Among Patients Admitted to Addis Ababa Intensive Care Units; a Cross-sectional Study.

Gebremedhin

Sultan

Tesfaye

2021

Preprint

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“…A study 12 Some studies documented CVC related bacteremia in 1.4% and CRBSI 0.2% of patients. 10 In this study, most common cause of CRBSI in Cardiac surgery ICU was found to be candida. Cases of candidemia in ICU are increasingly reported in the last decade.…”

Section: Discussionmentioning

confidence: 56%

“…CVC tip colonization with Candida was found in less than 1% of cases. 10 In this study, incidence of CLBSI was found to be 11.9%, Candida (37.5), S. aureus (25%), Klebsiella (25%) and Acinetobactor sp. (12.5%) were cause of CLBSI.…”

Section: Discussionmentioning

confidence: 57%

Frequency of Catheter Related Blood Stream Infections in a Cardiac Surgery Intensive Care Unit

Fatima¹,

Mehdi²,

Aslam³

2020

IJCMR

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“…4,5 Patients with indwelling CVCs are at enhanced risk of developing various catheter related infections (CRI) such as localized insertion site infections, septic thrombophlebitis, catheter related blood stream infections (CRBSI), bacteremia, metastatic infections, sepsis and if not promptly treated can result in patient's death. 6,7 Colonization of CVC tips and resultant healthcare associated bacteremia and septicemia can contribute towards enhanced patient morbidity and mortality. CRBSI is among most common causes of nosocomial bacteremia and is defined as the bacteremia originating from an indwelling intravenous catheter.…”

Section: Introductionmentioning

confidence: 99%

Frequency and antimicrobial susceptibility pattern of isolates in central venous catheter colonization.

Fatima

Mehdi

Aslam³

et al. 2020

TPMJ

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Colonization of central venous catheters increases the risk of blood stream infections and is associated with increased morbidity, mortality and excess hospital costs. Objectives: To estimate frequency of central venous catheter colonization. Study Design: Cross Sectional study. Setting: Microbiology Laboratory of Punjab Institute of Cardiology, Lahore. Period: May 2018 to December 2018. Material and Methods: Total 116 specimens of central venous catheters were received in the laboratory and processed to isolate various organisms. Organisms were identified on the basis of colonial morphology, Gram staining and biochemical tests. Antimicrobial sensitivity testing was performed and results were recorded. Results: Out of total 116 specimens of central venous catheters, bacterial growth was obtained from 74.1% of central venous catheter tips. From 86 cultures yielding growth, 94 micro-organisms were isolated. The most frequent organisms isolated from central venous catheter tip culture in decreasing order of frequency were Coagulase negative staphylococci (29.8%), S. aureus (24.5%), Candida species (23.4%), Klebsiella species (12.8%), and Acinetobacter spp. (4.3%). Drug susceptibility pattern of isolates was recorded. Conclusion: Central venous catheters can get colonized and lead to catheter related infections. Implementation of prevention programs can result in decrease in colonization rate of catheters and thus Catheter related infections.

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Bacteriological profile and their antimicrobial susceptibility pattern in central venous catheter tip culture

Cited by 3 publications

References 5 publications

Microbiological Profile, Antimicrobial Susceptibility, and Outcome Among Patients Admitted to Addis Ababa Intensive Care Units; a Cross-sectional Study.

Microbiological Profile, Antimicrobial Susceptibility, and Outcome Among Patients Admitted to Addis Ababa Intensive Care Units; a Cross-sectional Study.

Frequency of Catheter Related Blood Stream Infections in a Cardiac Surgery Intensive Care Unit

Frequency and antimicrobial susceptibility pattern of isolates in central venous catheter colonization.

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