Bacteriological Profile of Diabetic Foot in a Tertiary Care Centre in Trivandrum, India

Jitendranath, Ashish; Hegadi, Sneha; Bhai, Geetha; Bhargavi, L; Bai, Ramani; Vishu, T.

doi:10.20546/ijcmas.2016.506.031

Cited by 2 publications

(4 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the present study, Pseudomonas aeruginosa was the most common isolate, accounting for 51.7% of all NF-GNB. These results were similar to those reported in previous studies by Jitendranath et al, Juyal et al [ 21 , 25 ], and Grewal et al [ 8 ], who reported the same species as 57.7%, 38.21%, and 87.96%, respectively. In other studies such as those by Sarkar et al [ 26 ] and Shah and Vaghela [ 23 ], Acinetobacter baumannii was the most common non-fermenter accounting for 51.3% and 54.0%, respectively, contradictory to our study in which the prevalence of Acinetobacter baumannii was 23.4%.…”

Section: Discussionsupporting

confidence: 92%

“…NF-GNB are now emerging as important nosocomial pathogens causing hospital-acquired infections and opportunistic infections. Multidrug resistance has increased among these organisms due to the widespread use of antibiotics [ 21 ].…”

Section: Discussionmentioning

confidence: 99%

“…MDR Acinetobacter baumannii were highly susceptible to colistin (97.7%) and minocycline (64.4%) but poorly susceptible to ampicillin (16.1%) and ceftazidime (6.9%). In a study on non-fermenters from lower respiratory tract infections, all Acinetobacter isolates were MDR and were only susceptible to colistin (100%) [ 21 ]. Similar results by Nazir et al showed that Acinetobacter baumannii was highly susceptible to colistin (100%), followed by tigecycline (84%), imipenem (40%), ciprofloxacin (28%), amikacin (26%), and ceftazidime (20%) [ 27 ].…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Emergence of Multidrug-Resistant Non-Fermenting Gram-Negative Bacilli in a Tertiary Care Teaching Hospital of Central India: Is Colistin Resistance Still a Distant Threat?

Soni¹,

Kapoor²,

Perumal³

et al. 2023

Cureus

View full text Add to dashboard Cite

Purpose Multidrug-resistant (MDR) organisms are being increasingly reported from India. This study aimed to determine the antibiotic susceptibility pattern of non-fermenting Gram-negative bacilli (NF-GNB) isolated from all the clinical samples to estimate the prevalence of MDR MDR NF-GNB and to screen for colistin-resistance genes among all colistin-resistant strains. Materials and methods This prospective study conducted from January 2021 to July 2022 at a tertiary care teaching hospital in central India identified MDR NF-GNB from clinical samples using standard procedures and antimicrobial susceptibility testing conducted as per Clinical Laboratory Standards Institute (CLSI) guidelines. Colistin-resistant strains identified by broth microdilution were further subjected to detection of plasmid-mediated colistin-resistant genes ( mcr-1 , mcr-2 , mcr-3 ) by polymerase chain reaction (PCR). Results A total 2,106 NF-GNB were isolated from 21,019 culture positive clinical samples, of which 743 (35%) were MDR. Majority of MDR NF-GNB isolated were from pus (45.50%) followed by blood (20.50%). Out of 743 non-duplicate MDR non-fermenters,the most common were Pseudomonas aeruginosa (51.7%) , Acinetobacter baumannii (23.4%),and others (24.9%).Around5.2% Pseudomonas aeruginosa and 2.3% Acinetobacter baumannii were resistant to colistin, and 88.2% were resistant to ceftazidime. Burkholderia cepacia complexwas 100% susceptible to minocycline and least susceptible to ceftazidime (28.6%). Out of 11, 10 (90.9%) Stenotrophomonas maltophilia were susceptible to colistin and least susceptible to ceftazidime and minocycline (27.3%). All 33 colistin-resistant strains (minimal inhibitory concentration ≥ 4 µg/mL) were found to be negative for mcr-1 , mcr-2 , and mcr-3 genes. Conclusion Our study showed a significantly wide variety of NF-GNB, ranging from Pseudomonas aeruginosa (51.7%), Acinetobacter baumannii (23.4%),to Acinetobacter haemolyticus (4.6%), Pseudomonas putida (0.9%), Elizabethkingia meningoseptica (0.7%), Pseudomonas luteola (0.5%), and Ralstonia pickettii (0.4%), which have not been commonly reported in literature. Of all the non-fermenters isolated in the present study, 35.28% were MDR, raising the concern for rationalizing antibiotic use and improving infection control measures to avert or slow the emergence of antibiotic resistance.

show abstract

Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Emergence of Multidrug-Resistant Non-Fermenting Gram-Negative Bacilli in a Tertiary Care Teaching Hospital of Central India: Is Colistin Resistance Still a Distant Threat?

Soni¹,

Kapoor²,

Perumal³

et al. 2023

Cureus

View full text Add to dashboard Cite

show abstract

“…Monomicrobial nature of diabetic foot ulceration has been reported in several studies conducted in this region and elsewhere. [14,15] But few studies from India have reported a higher prevalence of necrotic cases and polymicrobial infections. [16][17][18] Microbiological evaluation of diabetic foot ulcer infections showed that the prevalence of gram-negative organisms was found to be more than gram-positive organisms.…”

Section: Discussionmentioning

confidence: 99%

Study on bacteriological profile and antibiotic susceptibility pattern in patients with diabetic foot ulcers in a tertiary care teaching hospital

Shareef¹,

Sunny²,

Bhagavan

2018

Journal of Social Health and Diabetes

View full text Add to dashboard Cite

Introduction:Diabetic foot ulcer and infections are one of the major complications in diabetic patients leading to frequent hospitalization and increased mortality. Knowledge about the microbes that cause infections will be helpful for providing appropriate antimicrobial therapy. Aim:To evaluate the bacteriological profile of patients with diabetic foot ulcers and their antibiotic susceptibility pattern. Methodology:A cross-sectional study was carried out for a period of eight months in the Department of surgery in patients with diabetic foot ulcer at a tertiary care teaching hospital. Patient data relevant to the study were collected using a standard data collection form designed as per the need of the study. Details of the organisms isolated and susceptibility pattern were collected from microbiology department. Results:A total of 122 pathogens were identified from 71 patients with male (63.38%) predominance over females (36.61%). Out of the 71 patients, 38 (53.52%) patients had monomicrobial infections and 33 (46.47%) patients had polymicrobial infections. Of the total 122 organisms, 79(64.75%) organisms were found to be gram negative organisms and 43(35.24%) were gram positive. Pseudomonas aeruginosa found in 22 (18.03%) patients was the predominant pathogen isolated followed by Klebsiella pneumonia found in 18 (14.75%) patients. The gram-positive organisms isolated showed maximum susceptibility towards antibiotics Teicoplanin and Linezolid while the gram-negative organisms showed susceptibility to Imipenem, Meropenem, and Piperacillin/Tazobactum combination. Conclusion:The study showed a preponderance of gram-negative bacilli among the isolates from the diabetic foot ulcers. It is recommended that antimicrobial sensitivity testing is necessary for initiating appropriate antibiotic regimen which will help to reduce the drug resistance and minimize the healthcare costs.

show abstract

Bacteriological Profile of Diabetic Foot in a Tertiary Care Centre in Trivandrum, India

Cited by 2 publications

References 3 publications

Emergence of Multidrug-Resistant Non-Fermenting Gram-Negative Bacilli in a Tertiary Care Teaching Hospital of Central India: Is Colistin Resistance Still a Distant Threat?

Emergence of Multidrug-Resistant Non-Fermenting Gram-Negative Bacilli in a Tertiary Care Teaching Hospital of Central India: Is Colistin Resistance Still a Distant Threat?

Study on bacteriological profile and antibiotic susceptibility pattern in patients with diabetic foot ulcers in a tertiary care teaching hospital

Contact Info

Product

Resources

About