Bacteriological Profile of Neonatal Sepsis in a Tertiary Hospital in Bangladesh

Begum, Suraiya; Ma, Bin; Gk, Kundu; Islam, Imnul; Kumar, Madhu; Haque, Afroza

doi:10.3329/jbcps.v30i2.11406

Cited by 30 publications

(32 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Therefore knowledge of pattern of the bacteriological profile and its antimicrobial susceptibility pattern can be very helpful for prompt empirical treatment of neonatal sepsis.This study was undertaken keeping these objectives in mind. Out of 300 study cases; male to female ratio 1.2:1 which is comparable to other studies like by Begums et al [18] Reason for male preponderance may be sex dependent factors as X-linked immunoregulatory genes may play some protective roles in females. [19] Positive blood culture was observed in 79% cases in the present study which is comparable to study by Premlata et al [20] showing blood culture positivity in 82% cases although the results are higher as compared to Karthikeyan et al [21] showing blood culture positivity in 51% cases.…”

Section: Discussionsupporting

confidence: 71%

Bacteriological Profile and Antibiogram of Community Acquired Neonatal Sepsis in a Tertiary Care Hospital; A Prospective Study

Singh¹,

Oberoi²,

Mehta³

et al. 2017

Ann. Int. Med. Den.Res.

View full text Add to dashboard Cite

Background: To isolate the pathogenic bacteria and to know the antibiotic sensitivity in the community acquired neonatal sepsis. Methods: It was a prospective study undertaken on 300 neonates suspected of community acquired neonatal sepsis admitted in Pediatrics Department of Government Medical College,Amritsar over a period of one year from January2014 to December 2014.All these cases fulfilled the inclusion criteria required for the study.Blood culture of these cases was performed by Mackie and McCartney method and antibiotic sensitivity by Kirley-Baner's disc diffusion method. Results: 227 (79%) cases showed positive blood culture.Gram negative isolates (N=156;65.82%) were more frequent than gram positive isolates (N=81;34.18%). Most common isolate was KlebsiellaPneumoniae (N=77%;32.48%) followed by Staphylococcus Aureus (N=66;27.84%), E.Coli(N=37;15.66%), Pseudomonas Aeroginosa (N=28;11.81%), Acinetobacter (N=14;5.90%), Enterococcus(N=8;3.37%) and Coagulase Negative Staphylococcus Aureus (N=7;2.99%). Both gram negative as well as gram positive isolates showed high resistance to ampicillin and gentamycin. Gram negative isolates were highly sensitive to Polymixin B and Meropenem whereas gram positive isolates were highly sensitive to Linezolid and Vancomycin. Conclusion: Gram negative bacteria were more frequent causes of community acquired neonatal septicemia than gram positive isolates. Both gram positive and negative isolates showed poor sensitivity towards conventional first line antibiotics, rather were mainly susceptible to higher antibiotics. So the knowledge of the pattern of bacteriological isolates and their antimicrobial susceptibility pattern can be very helpful for prompt treatment of such patients, to decrease neonatal morbidity and mortality as well as reducing the emergence of multi-drug resistant organisms.

show abstract

Section: Discussionsupporting

confidence: 71%

Bacteriological Profile and Antibiogram of Community Acquired Neonatal Sepsis in a Tertiary Care Hospital; A Prospective Study

Singh¹,

Oberoi²,

Mehta³

et al. 2017

Ann. Int. Med. Den.Res.

View full text Add to dashboard Cite

show abstract

“…Imipenem and meropenem were highly sensitive to all organisms. 59 In our study, Proteus was 100% sensitive to cephradine, cefoxitin, cefixime, ceftazidime, ceftriaxone, cefepime, cotrimoxazole, amikacin, ciprofloxacin, imipenem, meropenem, netilmicin, piperacillin+tazobactum combination, tetracycline, tigecycline, azithromycin, azactum and 100% resistant to doxycycline, tetracycline, chloramphenicol and cefuroxime.…”

Section: Discussionmentioning

confidence: 91%

Prevalent Bacteria and Their Sensitivity and Resistance Pattern to Antibiotics: A Study in Dhaka Medical College Hospital

Hossain

Naher²,

Hasan

et al. 2017

J Dhaka Med Coll

View full text Add to dashboard Cite

amikacin, moxifloxacin, imipenem, meropenem, piperacillin+tazobactum combination, vancomycin, doxycycline, tetracycline, tigecycline, nitrofurantoin, azactum, linezolid and 100% resistant to cefixime. Enterobacter was 100% sensitive to penicillin, amikacin, gentamicin, netilmicin, doxycycline, tetracycline, tigecycline and 100% resistant to cefixime, ceftazidime, ceftriaxone, cefepime, cotrimoxazole, levofloxacin, vancomycin. E. coli was 100% sensitive to imipenem, meropenem, vancomycin, tigecycline and 100% resistant to mecillinam, aztreonam. Klebsiella was 100% sensitive to flucloxacillin, colistin, vancomycin, tigecycline, linezolid and 100% resistant to nalidixic acid. Proteus was 100% sensitive to cephradine,

show abstract

“…Klebsiella spp. was the predominant pathogen in studies from India [20] and Bangladesh [26]. Predominance of gramnegative organisms may be due to the indiscriminate and inappropriate use of antibiotics, lack of hygienic practices at the place of delivery, poor cord care, and unhygienic newborn care practices [27].…”

Section: Discussionmentioning

confidence: 99%

Multidrug-resistant organisms in neonatal sepsis in two tertiary neonatal ICUs, Egypt

Awad

Mohamed

Badran

et al. 2016

Journal of the Egyptian Public Health Association

View full text Add to dashboard Cite

show abstract

Bacteriological Profile of Neonatal Sepsis in a Tertiary Hospital in Bangladesh

Cited by 30 publications

References 8 publications

Bacteriological Profile and Antibiogram of Community Acquired Neonatal Sepsis in a Tertiary Care Hospital; A Prospective Study

Bacteriological Profile and Antibiogram of Community Acquired Neonatal Sepsis in a Tertiary Care Hospital; A Prospective Study

Prevalent Bacteria and Their Sensitivity and Resistance Pattern to Antibiotics: A Study in Dhaka Medical College Hospital

Multidrug-resistant organisms in neonatal sepsis in two tertiary neonatal ICUs, Egypt

Contact Info

Product

Resources

About