Bacteriological Profile of Patients With Acute Pyogenic Meningitis - A Hospital Based Study

Abstract

BACKGROUND Pyogenic meningitis is one of the most common infectious disease emergencies involving the central nervous system with higher incidence in developing countries than developed nations. Despite the large number of pathogens that have been reported to cause acute pyogenic meningitis, certain microorganisms are isolated with higher frequency depending on patient's age, immune status and geography. Present study was aimed to determine the trends in aetiology and spectrum of the bacteriological profile in adult patients with suspected pyogenic meningitis in NorthEast India. MATERIALS 50 CSF samples from as many patients of Acute Bacterial Meningitis over a period of one year were processed for cell counts, biochemical analysis, gram staining, culture, antigen detection by latex agglutination test and antibiotic susceptibility tests, as per standard techniques. OBSERVATION CSF cell counts showed neutrophilic predominance in all cases along with high protein and low sugar levels. 44% of the cases were culture positive and latex agglutination test was positive in 46.4% of the cases where culture was negative. S. pneumonia was the predominant pathogen identified in the present study in 12(24%) cases, followed by Pseudomonas and E. coli in 5(10%) cases each. Gram stain indicated the causative organisms in 68.2% of the culture positive cases. Among the culture negative patients gram stain indicated the causative organism in 3(10.7%) cases and these three cases were positive by LAT also. CONCLUSION Simple, rapid, inexpensive tests like gram staining remain significant means for diagnosis of acute pyogenic meningitis in developing countries. LAT goes a long way in identifying the organisms where the cultures are negative. This study thus paves the way for larger studies in this region for better recognition of the predominant organisms and the empirical antibiotic regimens.

CSF analysis in a patient with meningitis with special reference to LDH

“…Acute infections of nervous system were the hugest issues in the medicine considering the way that early af irmation, gainful dynamic and brisk association of the treatment can be lifesaving (Dey et al, 2016).Acute tainting of the central tangible framework is the most generally perceived purpose behind fever related with signs and symptoms of central tactile framework disease. Most common infection of the CNS are meningitis and encephalitis.…”

“…Moderate or genuine squeal occur in~25% of survivors, despite the way that the particular rate contrasts with the debasing living thing. Ordinary squeal fuse decreased insightful limit, memory shortcoming, seizures, hearing hardship and drunkenness, and step aggravations (Dey et al, 2016). Therefore it is imperative to recognize CNS infections early and to treat them promptly and aggressively.…”