Bacteriological status of beef carcasses at a commercial abattoir before and after slaughterline improvements

Hudson, W R; Roberts, T. A.; Whelehan, O. P.

doi:10.1017/s0950268800061732

Cited by 17 publications

(8 citation statements)

References 9 publications

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“…The rapid high affinity actions of lysins may also minimize the effects of primary antibody responses (38,39). Moreover, lysins are effective on mucous membranes and other surfaces such as skin (40,41), which are major routes of infection/reservoirs for pathogens and where most conventional antibiotics are ineffective (42). Indeed, this is the milieu in which two members of the host "amidase-like" PG recognition immunity proteins operate (see below) (43).…”

mentioning

confidence: 99%

Role of Net Charge on Catalytic Domain and Influence of Cell Wall Binding Domain on Bactericidal Activity, Specificity, and Host Range of Phage Lysins

Low

Yang

Perego

et al. 2011

Journal of Biological Chemistry

137

130

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Background: Lytic enzymes (lysins) from bacteriophages are potential bactericidal agents. Results: Positive net charge on lysin catalytic domains is a major factor in determining lytic activity and host range. Conclusion: Lysins can be engineered to modify their dependence on their cell wall targeting domains. Significance: This work suggests a number of approaches for fine-tuning lysins as novel antibiotics.

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mentioning

confidence: 99%

Role of Net Charge on Catalytic Domain and Influence of Cell Wall Binding Domain on Bactericidal Activity, Specificity, and Host Range of Phage Lysins

Low

Yang

Perego

et al. 2011

Journal of Biological Chemistry

137

130

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“…The methods used were those that proved able to judge the hygienic condition of red meat carcasses and differentiate good and poor hygienic practices ( Whelehan et al . 1986 ; Hudson et al . 1987 ).…”

Section: Methodsmentioning

confidence: 99%

Antimicrobial susceptibility of enterococci recovered from commercial swine carcasses: effect of feed additives

Davies

Roberts²

1999

Lett Appl Microbiol

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Enterococcus faecium is an important nosocomial pathogen often displaying multiple antibiotic resistance. The increase in clinical isolates can be attributed in part to hospital practices in antibiotic usage, but there is concern that antibiotic‐resistant strains might also originate in animals fed rations containing antibiotic growth promoters. Ingestion of meat from carcasses contaminated with faecal enterococci might then result in human colonization or resistance gene transfer to human enterococci. Because there are few comparisons of bacteria isolated from matched animals that have, or have not, been fed a diet containing antibiotic, two such groups of pig carcasses were sampled at a commercial abattoir. Forty isolates from each group of pigs were tested for their resistance to avilamycin and tylosin. Although a modest number of pigs was examined, and the number of strains of E. faecium tested was small, there was no evidence that the feeding of a growth promoter caused selection of enterococci resistant to tylosin or avilamycin.

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“…In HAID, SA could possibly be spread from the nares to other skin sites. It would therefore be interesting to find out if isolates from the nares are the same as those from the skin and thus if elimination of the nasal source of SA with mupirocin would have any impact on the severity of skin lesions and the course of disease.…”

Section: Genetics Host and Environmental Factorsmentioning

confidence: 99%

HTLV‐1‐associated infective dermatitis: updates on the pathogenesis

McGill

Vyas

Shimauchi

et al. 2012

Experimental Dermatology

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HTLV-1-associated infective dermatitis (HAID) is the main paediatric manifestation of human T-cell lymphotropic virus type 1 (HTLV-1). It is characterised by a chronic exudative eczematous eruption and persistent infection with Staphylococcus aureus (SA) and beta-haemolytic streptococci (BHS). Prevalence is highest in the Caribbean and Brazil; however, cases have been reported in other HTLV-1 endemic regions. Approximately 20 million people worldwide are infected with HTLV-1 and only 5-10% suffer from disease. Other manifestations include adult T-cell leukaemia/lymphoma (ATLL) and tropical spastic paraparesis/HTLV-1-associated myelopathy (TSP/HAM). HAID may also progress to ATLL or TSP/HAM. Treatment options are limited to prolonged antibiotic therapy. The aim of this paper is to review existing evidence and propose new theories on the pathogenesis of HAID. The current view is that HTLV-1 infection is required and in susceptible individuals leads to immune dysregulation with subsequent immunosuppression and superinfection with SA and BHS. Evidence suggests that host, environment and genetic factors may play a causative role. Genetic factors within ethnic groups determine host immune response and carrier state or disease manifestation of HTLV-1 infection. Increased IgE levels may contribute to the SA and BHS superinfection in HAID. Additionally, the possible impact of filaggrin, skin proteinase dysregulation, Langerhans cell dysfunction and TH2 chemokines is highlighted. More than 45 years since the discovery of HAID, the exact pathogenesis is still not fully understood. Further research is still needed to clearly elucidate the exact pathogenic mechanism of HAID.

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Bacteriological status of beef carcasses at a commercial abattoir before and after slaughterline improvements

Cited by 17 publications

References 9 publications

Role of Net Charge on Catalytic Domain and Influence of Cell Wall Binding Domain on Bactericidal Activity, Specificity, and Host Range of Phage Lysins

Role of Net Charge on Catalytic Domain and Influence of Cell Wall Binding Domain on Bactericidal Activity, Specificity, and Host Range of Phage Lysins

Antimicrobial susceptibility of enterococci recovered from commercial swine carcasses: effect of feed additives

HTLV‐1‐associated infective dermatitis: updates on the pathogenesis

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