Bacteriophage P4: a satellite virus depending on a helper such as prophage P2

Six, Erich W.; Klug, Carol A.Connelly

doi:10.1016/0042-6822(73)90432-7

Cited by 171 publications

(113 citation statements)

References 17 publications

Supporting

Mentioning

113

Contrasting

Order By: Relevance

“…2 Interest in the P2-like phages was increased by Erich Six's discovery of helper-dependent or "satellite" phage P4, which depends upon P2 late genes for its propagation. 3 Since P2-like prophages are so widespread, we have written this article to assist investigators in identifying the functions of P2-like prophages found in the sequence analysis of bacterial genomes. This article summarizes briefly what is known about the P2 genome and gene function, pointing out salient differences with the related and also well-studied phage 186 as well as other P2-related phages of interest.…”

Section: Introductionmentioning

confidence: 99%

Bacteriophage P2

Christie

Calendar

2016

Bacteriophage

View full text Add to dashboard Cite

show abstract

Section: Introductionmentioning

confidence: 99%

Bacteriophage P2

Christie

Calendar

2016

Bacteriophage

View full text Add to dashboard Cite

show abstract

“…P2 can act as a helper during coinfection with P4 (1), though the P2 burst is drastically reduced due to "interference" with its lytic growth by the satellite (G. Deho and R. Goldstein, unpublished results). P2 can also help P4 during infection of a P2 lysogen - (1). In this latter case, P2 is derepressed by P4 and its DNA is replicated, though complete lytic development of the helper does not occur (B. Lindqvist and E. Six, personal communication; G. Deho and R. Goldstein, unpublished results).…”

mentioning

confidence: 99%

“…For lytic growth it depends on all known morphogenic gene products of a helper, such as coliphage P2, for the production of its capsid and tail (1,3). P2 can act as a helper during coinfection with P4 (1), though the P2 burst is drastically reduced due to "interference" with its lytic growth by the satellite (G. Deho and R. Goldstein, unpublished results).…”

mentioning

confidence: 99%

“…Satellite phage P4 is a defective bacteriophage that alone can only replicate its DNA and lysogenize the bacterial host (1,2) or maintain itself as an independent plasmid (D. Shore and R. Goldstein, unpublished results). For lytic growth it depends on all known morphogenic gene products of a helper, such as coliphage P2, for the production of its capsid and tail (1,3).…”

mentioning

confidence: 99%

“…P4 wt was isolated from a bacterial strain that also released helper bacteriophage (1). P4 viry is an immunity-insensitive clear-plaque mutant that is a derivative of P4 wt (1). L.B.…”

mentioning

confidence: 99%

See 2 more Smart Citations

Determination of capsid size by satellite bacteriophage P4.

Shore¹,

Dehò²,

Tsipis³

et al. 1978

Proc. Natl. Acad. Sci. U.S.A.

View full text Add to dashboard Cite

Satellite bacteriophage P4 requires all morphogenic gene products provided by a helper phage, such as coliphage P2, to assemble its own capsid, which is one-third the volume of the larger helper capsid. We have isolated a satellite phage P4 sid (size determination) mutant that is unable to direct the assembly of the small wild-type-size P4 capsid. Instead, this mutant produces P4 plaque-forming units with large P2-size capsids which contain two or three copies of the P4 sid, genome. P4 sid, is evidently mutated in a protein that is specifically responsible for determining the precise size and symmetry of the structure into which the helper P2 gene products will assemble. In addition, we have found that the physical size of the genome does not appear to lay an essential role in the proper assembly of the icosahedral capsid, since the majority of the P4 sidl plaque-forming units do not contain a complete capsidful of DNA.

show abstract

The integrase family of site-specific recombinases: regional similarities and global diversity.

Argos¹,

Landy²,

Abremski³

et al. 1986

The EMBO Journal

484

289

View full text Add to dashboard Cite

A combination of two methods for detecting distant relationships in protein primary sequences was used to compare the site‐specific recombination proteins encoded by bacteriophage lambda, phi 80, P22, P2, 186, P4 and P1. This group of proteins exhibits an unexpectedly large diversity of sequences. Despite this diversity, all of the recombinases can be aligned in their C‐terminal halves. A 40‐residue region near the C terminus is particularly well conserved in all the proteins and is homologous to a region near the C terminus of the yeast 2 mu plasmid Flp protein. This family of recombinases does not appear to be related to any other site‐specific recombinases. Three positions are perfectly conserved within this family: histidine, arginine and tyrosine are found at respective alignment positions 396, 399 and 433 within the well‐conserved C‐terminal region. We speculate that these residues contribute to the active site of this family of recombinases, and suggest that tyrosine‐433 forms a transient covalent linkage to DNA during strand cleavage and rejoining.

show abstract

Bacteriophage P4: a satellite virus depending on a helper such as prophage P2

Cited by 171 publications

References 17 publications

Bacteriophage P2

Bacteriophage P2

Determination of capsid size by satellite bacteriophage P4.

The integrase family of site-specific recombinases: regional similarities and global diversity.

Contact Info

Product

Resources

About