Bacteriophage therapy: a revitalized therapy against bacterial infectious diseases

Matsuzaki, Shigenobu; Rashel, Mohammad; Uchiyama, Jumpei; Sakurai, Shingo; Ujihara, Takako; Kuroda, Masayuki; Ikeuchi, Masahiko; Tani, Tohru; Fujieda, Mikiya; Wakiguchi, Hiroshi; Imai, Shosuke

doi:10.1007/s10156-005-0408-9

Cited by 353 publications

(258 citation statements)

References 101 publications

(112 reference statements)

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“…These findings supported the potential for phage therapy as an alternative to chemical antimicrobial agents (21,35,39,48,51). Such therapy would also be valuable in the context of emerging bacterial antibiotic resistance in both human therapeutics and agriculture.…”

Section: Discussionsupporting

confidence: 53%

“…The emergence of pathogenic bacteria resistant to antimicrobial agents has highlighted the need for alternative means to treat human and animal bacterial infections. In this context, there are new prospects for phage therapy in the form of the application or ingestion of phage particles as an alternative to antibiotics (1,11,14,21,32,35,41,48,51). A recent major breakthrough for phage therapy was the approval by the U.S. Food and Drug Administration of a cocktail of bacteriophages as a treatment for Listeria monocytogenes contamination in ready-to-eat meat and poultry products (5).…”

mentioning

confidence: 99%

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Fluorescence Correlation Spectroscopy To Study Diffusion and Reaction of Bacteriophages inside Biofilms

Briandet

Lacroix-Gueu

Renault

et al. 2008

Appl Environ Microbiol

138

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In the natural environment, most of the phages that target bacteria are thought to exist in biofilm ecosystems. The purpose of this study was to gain a clearer understanding of the reactivity of these viral particles when they come into contact with bacteria embedded in biofilms. Experimentally, we quantified lactococcal c2 phage diffusion and reaction through model biofilms using in situ fluorescence correlation spectroscopy with two-photon excitation. Correlation curves for fluorescently labeled c2 phage in nonreacting Stenotrophomonas maltophilia biofilms indicated that extracellular polymeric substances did not provide significant resistance to phage penetration and diffusion, even though penetration and diffusion were sometimes restricted because of the noncontractile tail of the viral particle. Fluctuations in the fluorescence intensity of the labeled phage were detected throughout the thickness of biofilms formed by c2-sensitive and c2-resistant strains of Lactococcus lactis but could never be correlated with time, revealing that the phage was immobile. This finding confirmed that recognition binding receptors for the viral particles were present on the resistant bacterial cell wall. Taken together, our results suggest that biofilms may act as "active" phage reservoirs that can entrap and amplify viral particles and protect them from harsh environments.

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Section: Discussionsupporting

confidence: 53%

mentioning

confidence: 99%

Fluorescence Correlation Spectroscopy To Study Diffusion and Reaction of Bacteriophages inside Biofilms

Briandet

Lacroix-Gueu

Renault

et al. 2008

Appl Environ Microbiol

138

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“…Phages continue to be used in place of antibiotics for the treatment of bacterial infections in the former Soviet Union and Eastern Europe (1,15,32,42). The ongoing active bacterial evolution of multidrug resistance has recently motivated the Western scientific community to reevaluate the therapeutic potential of phages for diverse bacterial infections that are often incurable with conventional chemotherapy (1,15,25,40). Phage therapy may be a viable alternative to antibiotics because it has already been proven to be medically superior to antibiotic therapy for certain uses (2,4,17,28,36,37).…”

Section: Fatality Rates Among Patients With Infections Caused Bymentioning

confidence: 99%

Efficacy of Bacteriophage Therapy against Gut-Derived Sepsis Caused by Pseudomonas aeruginosa in Mice

Watanabe

Matsumoto

Sano

et al. 2007

Antimicrob Agents Chemother

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192

130

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We evaluated the efficacy of bacteriophage (phage) therapy by using a murine model of gut-derived sepsis caused by Pseudomonas aeruginosa that closely resembles the clinical pathophysiology of septicemia in humans. Oral administration of a newly isolated lytic phage strain (KPP10) significantly protected mice against mortality (survival rates, 66.7% for the phage-treated group versus 0% for the saline-treated control group; P < 0.01). Mice treated with phage also had lower numbers of viable P. aeruginosa cells in their blood, liver, and spleen. The levels of inflammatory cytokines (tumor necrosis factor alpha TNF-␣, interleukin-1␤ [IL-1␤], and IL-6) in blood and liver were significantly lower in phage-treated mice than in phage-untreated mice. The number of viable P. aeruginosa cells in fecal matter in the gastrointestinal tract was significantly lower in phage-treated mice than in the saline-treated control mice. We also studied the efficacy of phage treatment for intraperitoneal infection caused by P. aeruginosa and found that phage treatment significantly improved the survival of mice, but only under limited experimental conditions. In conclusion, our findings suggest that oral administration of phage may be effective against gut-derived sepsis caused by P. aeruginosa.

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“…At first, scientists tried to develop different methods of dealing with viruses. Afterwards, viruses began to be used for various purposes, e.g., for drug delivery [1,2] or for fighting bacteria [3,4] and even other viruses [5].…”

Section: Introductionmentioning

confidence: 99%

Possible mechanism of inhibition of virus infectivity with nanoparticles

Khylko¹

2016

Semicond. Phys. Quantum Electron. Optoelectron.

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Abstract. The possible mechanism of inhibition of virus infectivity with nanoparticles has been considered both theoretically and experimentally. It has been supposed that inhibition is caused by action of the nanoparticles on specific molecules at the virus surface. A nanoparticle located close to the virus leads to the drastic increase in the local field intensity at this surface. It, in turn, leads to deformation (or destruction) of molecules that are responsible for virus absorption into the cell. When majority of these molecules are deformed, the virus loses its ability to penetrate into the cell and to cause a decease. This mechanism has been studied theoretically by applying the methods of nanophysics and experimental studying the absorption spectra of biological samples.

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Bacteriophage therapy: a revitalized therapy against bacterial infectious diseases

Cited by 353 publications

References 101 publications

Fluorescence Correlation Spectroscopy To Study Diffusion and Reaction of Bacteriophages inside Biofilms

Fluorescence Correlation Spectroscopy To Study Diffusion and Reaction of Bacteriophages inside Biofilms

Efficacy of Bacteriophage Therapy against Gut-Derived Sepsis Caused by Pseudomonas aeruginosa in Mice

Possible mechanism of inhibition of virus infectivity with nanoparticles

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