Bacteriophages: Effective Alternative to Antibiotics

Karthik, Kumaragurubaran; Muneeswaran, N. S.; Manjunathachar, H V; Gopi, M.; Appavoo, Elamurugan; Kalaiyarasu, Semmannan; Pawaiya, Rajveer Singh

doi:10.14737/journal.aavs/2014/2.3s.1.7

Cited by 18 publications

(25 citation statements)

References 43 publications

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“…Bacteriophage therapy has been used successfully for prevention of various food-borne pathogen like Salmonella, Listeria, etc. Hence, this therapy can also be helpful for prevention and control of Arcobacter infection with good perspectives at slaughter houses thereby checking the entry of this organism into the human food chain (Karthik et al 2014c). Experimental trials with medicinal herb extracts and spices with respect to their antimicrobial potential have demonstrated that chamomile, sage cinnamon, rosemary, bearberry extracts, which are conventionally practiced for gastric trouble, hinder the growth and development of Arcobacter (Cervenka et al 2006).…”

Section: Prevention and Controlmentioning

confidence: 99%

Arcobacter: an emerging food-borne zoonotic pathogen, its public health concerns and advances in diagnosis and control – a comprehensive review

Ramees

Dhama

Karthik

et al. 2017

Veterinary Quarterly

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138

130

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Arcobacter has emerged as an important food-borne zoonotic pathogen, causing sometimes serious infections in humans and animals. Newer species of Arcobacter are being incessantly emerging (presently 25 species have been identified) with novel information on the evolutionary mechanisms and genetic diversity among different Arcobacter species. These have been reported from chickens, domestic animals (cattle, pigs, sheep, horses, dogs), reptiles (lizards, snakes and chelonians), meat (poultry, pork, goat, lamb, beef, rabbit), vegetables and from humans in different countries. Arcobacters are implicated as causative agents of diarrhea, mastitis and abortion in animals, while causing bacteremia, endocarditis, peritonitis, gastroenteritis and diarrhea in humans. Three species including A. butzleri, A. cryaerophilus and A. skirrowii are predominantly associated with clinical conditions. Arcobacters are primarily transmitted through contaminated food and water sources. Identification of Arcobacter by biochemical tests is difficult and isolation remains the gold standard method. Current diagnostic advances have provided various molecular methods for efficient detection and differentiation of the Arcobacters at genus and species level. To overcome the emerging antibiotic resistance problem there is an essential need to explore the potential of novel and alternative therapies. Strengthening of the diagnostic aspects is also suggested as in most cases Arcobacters goes unnoticed and hence the exact epidemiological status remains uncertain. This review updates the current knowledge and many aspects of this important food-borne pathogen, namely etiology, evolution and emergence, genetic diversity, epidemiology, the disease in animals and humans, public health concerns, and advances in its diagnosis, prevention and control.

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Section: Prevention and Controlmentioning

confidence: 99%

Arcobacter: an emerging food-borne zoonotic pathogen, its public health concerns and advances in diagnosis and control – a comprehensive review

Ramees

Dhama

Karthik

et al. 2017

Veterinary Quarterly

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138

130

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“…Listeriophages have been found abundantly in silages of dairy farms (Vongkamjan et al 2012). In dairy industry, Ply511 phage has been used successfully to control Listeria (Gaeng et al 2000;Karthik et al 2014). FDAapproved commercial products of phages are presently available that can be used in poultry industries (Soni et al 2010).…”

Section: Novel and Emerging Therapies To Combat Listeriosismentioning

confidence: 99%

“…FDAapproved commercial products of phages are presently available that can be used in poultry industries (Soni et al 2010). ListexP-100 (the Netherlands) and ListShield (USA) are two of the products used to control Listeria organisms (Chibeu et al 2013;Karthik et al 2014). Bacteriocins such as nisin have been used in meat mince to inhibit L. monocytogenes (Pawar et al 2000).…”

Section: Novel and Emerging Therapies To Combat Listeriosismentioning

confidence: 99%

Listeriosis in animals, its public health significance (food-borne zoonosis) and advances in diagnosis and control: a comprehensive review

Dhama

Karthik

Tiwari

et al. 2015

Veterinary Quarterly

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133

108

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Listeriosis is an infectious and fatal disease of animals, birds, fish, crustaceans and humans. It is an important food-borne zoonosis caused by Listeria monocytogenes, an intracellular pathogen with unique potential to spread from cell to cell, thereby crossing blood-brain, intestinal and placental barriers. The organism possesses a pile of virulence factors that help to infect the host and evade from host immune machinery. Though disease occurrence is sporadic throughout the world, it can result in severe damage during an outbreak. Listeriosis is characterized by septicaemia, encephalitis, meningitis, meningoencephalitis, abortion, stillbirth, perinatal infections and gastroenteritis with the incubation period varying with the form of infection. L. monocytogenes has been isolated worldwide from humans, animals, poultry, environmental sources like soil, river, decaying plants, and food sources like milk, meat and their products, seafood and vegetables. Since appropriate vaccines are not available and infection is mainly transmitted through foods in humans and animals, hygienic practices can prevent its spread. The present review describes etiology, epidemiology, transmission, clinical signs, post-mortem lesions, pathogenesis, public health significance, and advances in diagnosis, vaccines and treatment of this disease. Special attention has been given to novel as well as prospective emerging therapies that include bacteriophage and cytokine therapy, avian egg yolk antibodies and herbal therapy. Various vaccines, including advances in recombinant and DNA vaccines and their modes of eliciting immune response, are also discussed. Due focus has also been given regarding appropriate prevention and control strategies to be adapted for better management of this zoonotic disease.

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“…Most multi-drug resistant microorganisms develop biofilms on the sites of wounds, posing difficulties in treatment with available antibiotics and thereby causing morbidity or mortality in infected patients (Karthik, 2014; Jin et al, 2019; Yuan et al, 2019). Biofilms are formed by the association of a variety of complex extracellular components such as polysaccharides, proteins, lipids, toxins, metabolites and DNA (Chan and Abedon, 2015; Sharma et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Bacteriophages inhibit biofilms formed by multi-drug resistant bacteria isolated from septic wounds

Rani

Lakshmi

Praasad

2019

Preprint

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Bacteriophages: Effective Alternative to Antibiotics

Cited by 18 publications

References 43 publications

Arcobacter: an emerging food-borne zoonotic pathogen, its public health concerns and advances in diagnosis and control – a comprehensive review

Arcobacter: an emerging food-borne zoonotic pathogen, its public health concerns and advances in diagnosis and control – a comprehensive review

Listeriosis in animals, its public health significance (food-borne zoonosis) and advances in diagnosis and control: a comprehensive review

Bacteriophages inhibit biofilms formed by multi-drug resistant bacteria isolated from septic wounds

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