Bacteriorhodopsin: a biological material for information processing

Oesterhelt, Dieter; Bräuchle, Christoph; Hampp, Norbert

doi:10.1017/s0033583500003863

Cited by 297 publications

(129 citation statements)

References 154 publications

(152 reference statements)

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“…The bR is polyanion (purple membrane fragments of Halobacterium salinarium or Halobacterium halobium) [230] with a single-chain polypeptide folded into seven α-helices which contain a single covalently bound chromophore present in every helix [231][232][233]. Thus, the bR is wellknown transmembrane protein working as a proton pump creating a light-driven pH gradient between intracellular and extracellular parts of purple bacteria [234][235][236][237][238]. The bright ion channels embedded in a lipid bilayer (approximately 5 nm thick) control the selective passage of ions and their movements from one side of the cell to the other [239].…”

Section: Non-fluorescent Prodrugs/converted Into Fluorescent Active Dmentioning

confidence: 99%

Fluorescent Dyes Used in Polymer Carriers as Imaging Agents in Anticancer Therapy

Miksa¹

2016

Med chem (Los Angeles)

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This review highlights the role of fluorescent dyes as active "molecular photoswiches" focusing on the application in bioimaging and anticancer therapies in the field of therapeutic delivery. The author describes the development of prodrugs targeted to specific cell types and polymeric nanocarriers (capsules, micelles and silica nanoparticles) used as fluorescent probes which offer advantages in the integration of "smart" features of fluorescent dyes into synthetic materials. The incorporation of biologically responsive components that cleave upon changes in pH or light irradiation is fundamental to the successful design of such carriers with capabilities to load and release therapeutics specifically at a target site.

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Section: Non-fluorescent Prodrugs/converted Into Fluorescent Active Dmentioning

confidence: 99%

Fluorescent Dyes Used in Polymer Carriers as Imaging Agents in Anticancer Therapy

Miksa¹

2016

Med chem (Los Angeles)

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“…Much of the current research effort in biological nanotechnology is directed toward self-assembled monolayers and thin films, biosensors, and protein-based photonic devices [1][2][3][4][5][6]. Although a number of proteins have been explored for device applications, bacteriorhodopsin [3] has received, it seems, the most attention.…”

Section: Introductionmentioning

confidence: 99%

Very Fast Algorithms for Eliminating the Diffraction Effects in Protein-Based Volumetric Memories

Trincâ¹,

Rajasekaran

2023

JSAME

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One of the current research directions in biological nanotechnology is the use of bacteriorhodopsin in the fabrication of protein-based volumetric memories. Bacteriorhodopsin, with its unique light-activated photocycle, nanoscale size, cyclicity (>10 7 ), and natural resistance to harsh environmental conditions, provides for protein-based volumetric memories that have a comparative advantage over magnetic and optical data storage devices. The construction of protein-based volumetric memories has been, however, severely limited by fundamental issues that exist with such devices, such as unwanted diffraction effects. In this paper, we propose some optimizations that can be applied to one of the previously proposed algorithms for eliminating the diffraction effects.

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“…The changes in the protein's absorption profile during photochemical transformations allow one to create optical logic gates based on BR. Owing to these properties, BR is a promising material for applications in optoelectronics [1]. However, the spectral region in which BR effectively absorbs light is limited to the band with a maximum at 568 nm, whereas…”

Section: Introductionmentioning

confidence: 99%

Laser Irradiation as a Tool to Control the Resonance Energy Transfer in Bacteriorhodopsin–Quantum Dot Bio-Nano Hybrid Material

Krivenkov¹,

Samokhvalov²,

Chistyakov³

et al. 2018

KEn

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Bacteriorhodopsin (BR) is a natural photosensitive protein which can be considered promising in photovoltaics and optoelectronics because of its ability to produce a pronounced electrochemical response and controllably change its absorption spectrum under light excitation. However, its applicability is limited by its narrow absorption spectrum and low values of the absorption cross sections. Semiconductor quantum dots (QDs), which have high one-and two-photon absorption cross-sections in a UVand NIR spectral regions, respectively, can significantly improve the light sensitivity of BR by means of Förster resonance energy transfer (FRET) from QD to BR. In this work, we demonstrate the possibility to control the efficiency of FRET from QD to BR within electrostatically bound complexes of QD and purple membranes (PM) containing BR. We show that laser irradiation of QDs at different wavelengths leads to distinct changes (rise or decrease) of QD luminescence quantum yield (QY) without changing of QD structure. Such photo-induced changes in the QY of QD lead to a corresponding change in the efficiency of FRET. We have estimated efficiencies of FRET from QD to BR in the PM complexes composed of irradiated and non-irradiated QDs and found the increase in FRET efficiency with irradiated QDs.

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Bacteriorhodopsin: a biological material for information processing

Cited by 297 publications

References 154 publications

Fluorescent Dyes Used in Polymer Carriers as Imaging Agents in Anticancer Therapy

Fluorescent Dyes Used in Polymer Carriers as Imaging Agents in Anticancer Therapy

Very Fast Algorithms for Eliminating the Diffraction Effects in Protein-Based Volumetric Memories

Laser Irradiation as a Tool to Control the Resonance Energy Transfer in Bacteriorhodopsin–Quantum Dot Bio-Nano Hybrid Material

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