2010
DOI: 10.1292/jvms.08-0331
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Bacteriostatic Activity of Whey Acidic Protein (WAP)

Abstract: ABSTRACT. We have previously reported the action of whey acidic protein (WAP) inhibiting the proliferation of mouse mammary epithelial cells in the experiments utilizing in vivo and in vitro systems. We report herein the bacteriostatic activity of WAP. Western blot analysis demonstrated successful isolation of WAP from whey fractions of rat milk by column chromatography. The WAP fraction inhibited the growth of Staphylococcus aureus JCM2413 in a dose-dependent manner, but did not inhibit the growth of Escheric… Show more

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Cited by 16 publications
(10 citation statements)
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“…The mouse SWAM1 and 2 have antibacterial activity but not the antiproteinase activity [11]. The WAP from rat milk inhibits the growth of S. aureus JCM2413 [13]. A related WFDC2 protein from milk of tammar wallaby also exhibits antibacterial activity against S. aureus, Salmonella enterica and Pseudomonas aeruginosa and this activity resides with the second WAP domain [30].…”
Section: Mutagenesis and Recombinant Expressionmentioning
confidence: 99%
“…The mouse SWAM1 and 2 have antibacterial activity but not the antiproteinase activity [11]. The WAP from rat milk inhibits the growth of S. aureus JCM2413 [13]. A related WFDC2 protein from milk of tammar wallaby also exhibits antibacterial activity against S. aureus, Salmonella enterica and Pseudomonas aeruginosa and this activity resides with the second WAP domain [30].…”
Section: Mutagenesis and Recombinant Expressionmentioning
confidence: 99%
“…The role of milk in the growth, development and disease protection of young is yet to be established and there is speculation that the survival of eggs and the young of monotremes is enhanced by microbial inhibitors of cutaneous or mammary gland origin [8], [9]. Protective properties of milk in a vast range of mammals have been reported: for example, anti- parasitic activity of human milk lipase [10], antimicrobial activity of tammar wallaby milk cathelicidins and WFDC2 protein [11], [12], antifungal activity of bovine milk lactoferrin [13] and bacteriostatic activity of murine milk whey acidic protein [14]. In this study, for the first time, we identify a novel, monotreme-specific transcript that shows abundant expression in the milk cells during late- lactation.…”
Section: Introductionmentioning
confidence: 99%
“…They, therefore, play a significant role in controlling the extent of neutrophil proteinase activity during inflammatory responses and tissue repair. They exhibit also the antimicrobial activity against bacteria [7,8], fungi [9,10] and viruses [11,12]. Recently, the expression of elafin and SLPI was found to be modulated in response to the onset of cancer [13e16].…”
Section: Introductionmentioning
confidence: 99%