Bacteriostatic and Bactericidal Activities of Tigecycline against Coxiella burnetii and Comparison with Those of Six Other Antibiotics

Abstract

The present article is a study of the in vitro susceptibility of eight Greek Coxiella burnetii isolates, derived from patients with acute Q fever, and two reference strains of Coxiella burnetii to tigecycline. The bacteriostatic activity of tigecycline was compared with those of six other antibiotics using a shell vial assay. The MICs of the examined antibiotics were as follows: tigecycline ranged from 0.25 to 0.5 g/ml; doxycycline, trovafloxacin, and ofloxacin ranged from 1 to 2 g/ml; linezolid and clarithromycin ranged from 2 to 4 g/ml; and ciprofloxacin ranged from 4 to 8 g/ml. Tigecycline was effective in inhibiting the infection of Vero cells by C. burnetii. No bactericidal activity was observed against C. burnetii at 4 g/ml.

Treatment of Q fever in Beef Cattle in Queensland, Australia: Historical Context, Present Scenario and Future Perspectives

“…39 New generation antibiotics are being applied in clinical trials. 40,41 In some paediatric cases, gamma-interferon is the treatment of choice. 42 The Australian National Vaccination Program was launched in 2001.…”

Queensland tick typhus: three cases with unusual clinical features

“…The second case was successfully treated with intravenous tigecycline, which has not been previously used in this setting to the best of our knowledge. A previous study showed low minimum inhibitory concentration values when tigecycline was tested with Coxiella burnetii strains, although information relating to Rickettsia species is lacking …”

“…A previous study showed low minimum inhibitory concentration values when tigecycline was tested with Coxiella burnetii strains, although information relating to Rickettsia species is lacking. 1 There are several reports of splenic infarction occurring in the context of a rickettsial infection. A 41-year-old man in Los Angeles with murine typhus (R. typhi) had several splenic infarcts, which necessitated splenectomy.…”

<b><i>Coxiella burnetii</i></b> - Pathogenic Agent of Q (Query) Fever

“…Some authors recommend lifelong treatment in the case of endocarditis [112] since repeated reactivations (relapses) have been observed during treatment interruptions [45]. More recent alternatives for antibiotic treatment include tigecycline and clarithromycin [114]. …”

“…The detection of C. burnetii in cell culture is performed on L929 fibroblasts or other cells such as vero cells [27,114,115]. For analysis, samples are extracted after filtration using 0.45 µm filters.…”