Bacteroides vulgatus Ameliorates Lipid Metabolic Disorders and Modulates Gut Microbial Composition in Hyperlipidemic Rats

Abstract

As a core microbe of the human gut ecosystem, Bacteroides vulgatus has been linked to multiple aspects of metabolic disorders in a collection of associative studies, which, while indicative, warrants more direct experimental evidence to verify. In this study, we experimentally demonstrated that oral administration of B. vulgatus Bv46 ameliorated the serum lipid profile and systemic inflammation of high-fat diet-induced hyperlipidemic rats in a microbiome-regulated manner, which appears to be associated with changes of bile acid metabolism, short-chain fatty acid biosynthesis, and serum metabolomic profile.

Multi-omic integration of microbiome data for identifying disease-associated modules

“…The exact role of B. vulgatus in the development of metabolic disorders, however, remains unclear and is probably context-and strain-dependent, as it has been shown to confer health benefits (including metabolic related) in some studies, while positively correlating with insulin resistance and body fat in others 7,69,[72][73][74][75] . Interestingly, B. vulgatus was also reported to induce compositional shifts when administered to rats, specifically promoting an increase in Parabacteroides species that is also included in this module 72 . Parabacteroides mardeae, another species in this module, has also been shown to enhance BCAA catabolism, again with positive health benefits 76 , albeit significantly increased in MS patients in our dataset.…”

“…B. vulgatus specifically was also reported to take part in glutamate metabolism 70 and further recognized as one of the main species driving the association between biosynthesis of BCAAs in the gut and insulin resistance 7,71 . The exact role of B. vulgatus in the development of metabolic disorders, however, remains unclear and is probably context-and strain-dependent, as it has been shown to confer health benefits (including metabolic related) in some studies, while positively correlating with insulin resistance and body fat in others 7,69,[72][73][74][75] . Interestingly, B. vulgatus was also reported to induce compositional shifts when administered to rats, specifically promoting an increase in Parabacteroides species that is also included in this module 72 .…”

Effects of Oat β-Glucan and Inulin on Alleviation of Nonalcoholic Steatohepatitis Aggravated by Circadian Disruption in C57BL/6J Mice

“…38 Previously, B. vulgatus Bv46 and B. vulgatus 7K1 have been reported to increase the production of SCFAs, which are accompanied by an attenuation of lipid metabolic disorder and dextran sulfate sodium-induced colitis, respectively. 39,40 However, it was discovered that the stools of advanced fibrosis patients were enriched with enzymes associated with butyric acid. 37 Therefore, we speculate that the increase in butyric acid observed in the SFPC group was attributed to the increased abundance of certain SCFA-producing B. vulgatus strains, which are less likely to be beneficial in our study.…”

The gut microbiome meets nanomaterials: exposure and interplay with graphene nanoparticles

“…128 Microbiomeregulated bile acid metabolism, SCFA biosynthesis, especially that of propionate and butyrate, and metabolic processes can contribute to host metabolism, including hyperlipidemia management. 129 There is evidence that graphene nanostructures can protect against colitis. 130,131 In dextran sulfate sodium (DSD)-induced colitis mice, following oral (4 times, once every three days) administration of 3% solution (1 mg mL −1 ) of graphene quantum dots (GQDs), amelioration of the disease severity was observed.…”

“…128 Microbiome-regulated bile acid metabolism, SCFA biosynthesis, especially that of propionate and butyrate, and metabolic processes can contribute to host metabolism, including hyperlipidemia management. 129…”