Bacteroidetes and Firmicutes levels in gut microbiota and effects of hosts TLR2/TLR4 gene expression levels in adult type 1 diabetes patients in Istanbul, Turkey

Demırci, Mehmet; Tokman, Hrisi Bahar; Taner, Zeynep; Keskin, Fatma Ela; Çağatay, Penbe; Bakar, Yeşim; Özyazar, Mücahit; Kiraz, Nuri̇; Kocazeybek, Bekir

doi:10.1016/j.jdiacomp.2019.107449

Cited by 56 publications

(46 citation statements)

References 27 publications

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“…In this study, there were significant decrease of Firmicutes , and significant increase of Bacteroidetes and Bacteroidetes/Firmicutes ratio in POI women. It was consistent with the microbial community structure of type 1 diabetes and systemic lupus erythematosus patients, with a low proportion of Firmicutes, high proportion of Bacteroidetes and Bacteroidetes/Firmicutes ratio [ 10 , 19 ]. Moreover, genera Dorea and Sutterella were more abundant in POI group.…”

Section: Discussionsupporting

confidence: 78%

Association between premature ovarian insufficiency and gut microbiota

Zhuo

Liu

et al. 2021

BMC Pregnancy Childbirth

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Background Premature ovarian insufficiency (POI) is characterized by impairment of ovarian function on a continuum before the age of 40 years. POI is affected by multiple factors. Considering new insights from recent gut microbiome studies, this study aimed to investigate the relationship between gut microbial community structure and POI. Methods Subjects were recruited at the Shenzhen Maternity & Child Healthcare Hospital. Fecal microbial community profiles of healthy women (n = 18), women with POI (n = 35) were analyzed using 16S rRNA gene sequencing based on Illumina NovaSeq platform. Results Compared to the controls, the serum levels of FSH, LH, T and FSH/LH ratio significantly increased in women with POI, whereas E2 and AMH decreased significantly. Higher weighted UniFrac value was observed in POI women compared with healthy women. Phylum Firmicutes, genera Bulleidia and Faecalibacterium were more abundant in healthy women, while phylum Bacteroidetes, genera Butyricimonas, Dorea, Lachnobacterium and Sutterella enriched significantly in women with POI. Moreover, these alterations of the gut microbiome in women with POI were closely related to FSH, LH, E2, AMH level and FSH/LH ratio. Conclusions Women with POI had altered microbial profiles in their gut microbiome, which were associated with serum hormones levels. These results will shed a new light on the pathogenesis and treatment for POI.

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Section: Discussionsupporting

confidence: 78%

Association between premature ovarian insufficiency and gut microbiota

Zhuo

Liu

et al. 2021

BMC Pregnancy Childbirth

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“…The ratio of Firmicutes to Bacteroidetes was positively related to fecal SCFAs (23). A Danish study found that the ratio of Firmicutes to Bacteroidetes in patients with type 2 diabetes was lower than those in non-diabetic subjects (24,25). It has been verified that the ratio of Firmicutes to Bacteroidetes was also negatively correlated to fasting blood glucose levels and inflammation status (26).…”

Section: Discussionmentioning

confidence: 96%

Dapagliflozin Modulates the Fecal Microbiota in a Type 2 Diabetic Rat Model

Yang

Shi

et al. 2020

Front. Endocrinol.

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“…There is increasing evidence to suggest that the gut microbiota plays an integral role in this altered trajectory from early life in both animal and human studies (Tables 1 and 2, respectively). Multiple studies have demonstrated that patients with T1D have distinctly different gut microbiota, in comparison with healthy subjects, characterized by a decreased Firmicutes (Grampositive): Bacteroidetes (Gram-negative) ratio [66][67][68][69][70]. Bacteroides were more prevalent in patients with T1D in association with an increase in inflammatory cytokine, interleukin (IL)-6, and poor glycemic control [71].…”

Section: Short Chain Fatty Acid Interaction With End-organ Receptorsmentioning

confidence: 99%

The Role of the Gut Microbiome in Diabetes and Obesity-Related Kidney Disease

Zaky

Glastras

Wong

et al. 2021

IJMS

107

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Diabetic kidney disease (DKD) is a progressive disorder, which is increasing globally in prevalence due to the increased incidence of obesity and diabetes mellitus. Despite optimal clinical management, a significant number of patients with diabetes develop DKD. Hence, hitherto unrecognized factors are likely to be involved in the initiation and progression of DKD. An extensive number of studies have demonstrated the role of microbiota in health and disease. Dysregulation in the microbiota resulting in a deficiency of short chain fatty acids (SCFAs) such as propionate, acetate, and butyrate, by-products of healthy gut microbiota metabolism, have been demonstrated in obesity, type 1 and type 2 diabetes. However, it is not clear to date whether such changes in the microbiota are causative or merely associated with the diseases. It is also not clear which microbiota have protective effects on humans. Few studies have investigated the centrality of reduced SCFA in DKD development and progression or the potential therapeutic effects of supplemental SCFAs on insulin resistance, inflammation, and metabolic changes. SCFA receptors are expressed in the kidneys, and emerging data have demonstrated that intestinal dysbiosis activates the renal renin-angiotensin system, which contributes to the development of DKD. In this review, we will summarize the complex relationship between the gut microbiota and the kidney, examine the evidence for the role of gut dysbiosis in diabetes and obesity-related kidney disease, and explore the mechanisms involved. In addition, we will describe the role of potential therapies that modulate the gut microbiota to prevent or reduce kidney disease progression.

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Bacteroidetes and Firmicutes levels in gut microbiota and effects of hosts TLR2/TLR4 gene expression levels in adult type 1 diabetes patients in Istanbul, Turkey

Cited by 56 publications

References 27 publications

Association between premature ovarian insufficiency and gut microbiota

Association between premature ovarian insufficiency and gut microbiota

Dapagliflozin Modulates the Fecal Microbiota in a Type 2 Diabetic Rat Model

The Role of the Gut Microbiome in Diabetes and Obesity-Related Kidney Disease

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