Bacupari (Garcinia brasiliensis) extract modulates intestinal microbiota and reduces oxidative stress and inflammation in obese rats

Araújo, Fernanda de Oliveira; Moreira, Maria Eliza de Castro; Lima, Cássio Furtado; Toledo, Renata Celi Lopes; Sousa, Andressa Rodrigues de; Veloso, Márcia Paranho; Freitas, Poliany G.; Santos, Marcelo H. dos; Souza, Eliana Carla Gomes de; Mantovani, Hilário Cuquetto; Martino, Hércia Stampini Duarte

doi:10.1016/j.foodres.2019.04.012

Cited by 13 publications

(8 citation statements)

References 45 publications

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“…Simultaneously, the reduction of B. longum, B. adolescentis and Clostridium coccoides as well as the increase in Bacteroides fragilis and Lactobacilli have been reported in obese adolescents who lose over 4 kg weight as a result of caloric-restriction diet and exercise (Nadal et al 2009;Santacruz et al 2009). It has been shown that the ethanoic extracts of Garcinia brasiliensis can effectively reduce the growth of Firmicutes and Proteobacteria together with the expressions of an oxidative stress marker malondialdehyde (Ara ujo et al 2019). Another study suggests that the Sargassum fusiforme fucoidan can improve antioxidant status by lowering malondialdehyde levels, increasing GSH/GSSG ratio and activating Nrf2 signalling pathway in a mechanism involving the promotion of Bacteroides, Alistipes, Lactobacillus and reduction of Helicobacter in HFD-fed mice (Zhang et al 2020).…”

Section: Gm and Oxidative Stressmentioning

confidence: 96%

Impact of the factors shaping gut microbiota on obesity

et al. 2021

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Obesity is considered as a risk factor for chronic health diseases such as heart diseases, cancer and diabetes 2. Reduced physical activities, lifestyle, poor nutritional diet and genetics are among the risk factors associated with the development of obesity. In recent years, several studies have explored the link between the gut microbiome and the progression of diseases including obesity, with the shift in microbiome abundance and composition being the main focus. The alteration of gut microbiome composition affects both nutrients metabolism and specific gene expressions, thereby disturbing body physiology. Specifically, the abundance of fibre-metabolizing microbes is associated with weight loss and that of protein and fat-metabolizing bacteria with weight gain. Various internal and external factors such as genetics, maternal obesity, mode of delivery, breastfeeding, nutrition, antibiotic use and the chemical compounds present in the environment are known to interfere with the richness of the gut microbiota (GM), thus influencing weight gain/loss and ultimately the development of obesity. However, the effectiveness of each factor in potentiating the shift in microbes' abundance to result in significant changes that can lead to obesity is not yet clear. In this review, we will highlight the factors involved in shaping GM, their influence on obesity and possible interventions. Understanding the influence of these factors on the diversity of the GM and how to improve their effectiveness on disease conditions could be keys in the treatment of metabolic diseases.

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Section: Gm and Oxidative Stressmentioning

confidence: 96%

Impact of the factors shaping gut microbiota on obesity

et al. 2021

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“…MDA concentration also decreased with mangosteen drink supplementation compared to the control group; however, there was no decrease of malondialdehyde in muscle. Araújo et al (2019) performed in vivo tests in mice that were ingesting ethanolic extract of G. brasiliensis leaves daily to evaluate its antioxidant activity, modulation of the intestinal microbiota and antiinflammatory activity. The ethanolic extract of the leaf contained the biflavonoid morelloflavone and the benzophenone 7-epiclusianone.…”

Section: Antioxidant Activity Of Extracts and Metabolites Of Garcinia...mentioning

confidence: 99%

“…They concluded that the extract was able to reduce oxidative stress, demonstrated by the increase in the amount of antioxidant enzymes. It inhibited the inflammatory process, modulated the intestinal microbiota, favoring beneficial bacteria and regulating lipid metabolism, which reduces obesity (Araújo et al, 2019). The ethyl acetate extract of the seeds e from G. kola was evaluated by Idris et al (2020) for in vivo antioxidant, anti-inflammatory and antidiabetic activities.…”

Section: Antioxidant Activity Of Extracts and Metabolites Of Garcinia...mentioning

confidence: 99%

Antioxidant property of secondary metabolites from Garcinia genus: A short review

Kazmierczak

Magalhães²,

Pereira

2023

Eclet. Quim.

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Species from the Garcinia genus (Clusiaceae family) are used in the treatment of many diseases and metabolic disorders frequently associated with the oxidative stress. The characteristic metabolites found in this genus are xanthones and benzophenones, which have antioxidant properties, among relevant biological potentials. This review provides a specific vision about antioxidant activity of Garcinia species, reporting in vitro and in vivo assays, described from the last five years. The research about antioxidant properties of Garcinia species and their constituents can be directed in the development of new medicines and drugs.

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“…High-fat diet consumption over a period of 7 and 8 weeks has been widely used to induce metabolic changes in animals. 21,26 According to this protocol, the intake of a specific food with claimed health beneficial effects as an obesity treatment is determined to be initiated after 7 or 8 weeks of receiving the high-fat diet. Differently, to verify the black corn whole flour effects in a preventive context, in our study, black corn was added in the diet while offering the high-fat diets to verify its preventive effects during the development of the undesirable metabolic changes.…”

Section: Papermentioning

confidence: 99%