Baeyer‐Villiger Oxidation

Abstract

Oxidation of ketones or cyclic ketones into esters or lactones by peracids or hydrogen peroxide is known as the Baeyer–Villiger oxidation. Some of the typical peracids have been found to involve in this type of the reaction are peroxybenzoic acid, m ‐chloroperoxybenzoic acid ( m CPBA), peroxyacetic acid, and trifluoroperoxyacetic acid. In this reaction the substituted group often migrates in the following order: tertiary > secondary > cyclohexyl > benzyl >phenyl > primary > methyl and stereochemistry and chirality of the migrating group are retained during the reaction. This reaction has wide application in the synthesis of esters and lactones.This reaction has been extensively reviewed and modified using bis[trimethylsilyl]peroxide or basic hydrogen peroxide.